Bovine Leukemia Virus and Human Breast Cancer: A Review of Clinical and Molecular Evidence DOI Creative Commons
Rancés Blanco, Claudio Quezada‐Romegialli, Juan P. Muñoz

и другие.

Viruses, Год журнала: 2025, Номер 17(3), С. 324 - 324

Опубликована: Фев. 26, 2025

Despite significant advancements in early diagnosis and treatment, breast cancer (BC) remains a major global health challenge. Ongoing research is essential to identify novel risk factors, implement innovative screening programs, develop personalized treatment approaches. Among the various infection with certain oncogenic viruses has emerged as potential contributor BC development. Increasing evidence suggests that bovine leukemia virus (BLV) may contribute zoonotic infections humans, role initiation progression. This review evaluates clinical experimental data on BLV presence both malignant non-malignant tissues, exploring mechanisms through which access human tissue carcinogenesis. Current reveal higher prevalence of tissues compared non-tumor correlating an increased In this context, dairy meat products from BLV-infected animals have been proposed transmission sources. BLV-encoded proteins disrupt key pathways, support their possible However, interpretation these findings limited by confounding factors such genetic predisposition, environmental exposures, dietary influences. Further research, including well-controlled epidemiological studies, longitudinal cohorts, mechanistic investigations into cells, necessary determine its

Язык: Английский

Optimizing therapeutic approaches for HR+/HER2- advanced breast cancer: clinical perspectives on biomarkers and treatment strategies post-CDK4/6 inhibitor progression DOI Open Access

J.M. Cejalvo Andujar,

Francisco Ayala de la Peña, Mireia Margelí Vila

и другие.

Cancer Drug Resistance, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

This review offers an expert perspective on biomarkers, CDK4/6 inhibitor efficacy, and therapeutic approaches for managing hormone receptor-positive (HR+), human epidermal growth factor receptor-negative (HER2-) advanced breast cancer (ABC), particularly after progression. Key trials have demonstrated that combining inhibitors with endocrine therapy (ET) significantly improves progression-free survival (PFS), median durations ranging from 14.8 to 26.7 months, overall (OS), reaching up 53.7 months. Actionable such as PIK3CA ESR1 mutations, emerged pivotal tools guide second-line treatment decisions, enabling the use of targeted therapies like alpelisib elacestrant emphasizing important role biomarkers in guiding selection therapy. overview aims provide clinicians a practical up-to-date framework inform decisions improve patient care context this challenging disease. Additionally, we emerging novel strategies address difficult clinical landscape.

Язык: Английский

Процитировано

1
Bovine Leukemia Virus and Human Breast Cancer: A Review of Clinical and Molecular Evidence DOI Creative Commons
Rancés Blanco, Claudio Quezada‐Romegialli, Juan P. Muñoz

и другие.

Viruses, Год журнала: 2025, Номер 17(3), С. 324 - 324

Опубликована: Фев. 26, 2025

Despite significant advancements in early diagnosis and treatment, breast cancer (BC) remains a major global health challenge. Ongoing research is essential to identify novel risk factors, implement innovative screening programs, develop personalized treatment approaches. Among the various infection with certain oncogenic viruses has emerged as potential contributor BC development. Increasing evidence suggests that bovine leukemia virus (BLV) may contribute zoonotic infections humans, role initiation progression. This review evaluates clinical experimental data on BLV presence both malignant non-malignant tissues, exploring mechanisms through which access human tissue carcinogenesis. Current reveal higher prevalence of tissues compared non-tumor correlating an increased In this context, dairy meat products from BLV-infected animals have been proposed transmission sources. BLV-encoded proteins disrupt key pathways, support their possible However, interpretation these findings limited by confounding factors such genetic predisposition, environmental exposures, dietary influences. Further research, including well-controlled epidemiological studies, longitudinal cohorts, mechanistic investigations into cells, necessary determine its

Язык: Английский

Процитировано

0