Building a Therapeutic Bridge Between Dogs and Humans: A Review of Potential Cross-Species Osteosarcoma Biomarkers DOI Open Access

Agnieszka Dolnicka,

Vibeke Fosse, Anna Raciborska

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5152 - 5152

Опубликована: Май 28, 2025

Osteosarcoma (OSA) is a naturally occurring malignant bone tumor in both humans and canines that characterized by aggressive local behavior high propensity for metastasis. Despite advances diagnostic methods therapies, long-term survival rates have remained stagnant, underscoring the great need development of biomarkers serving prognosis diagnosis OSA across species. Biomarkers, molecular indicators disease presence or progression, are pivotal tools oncology, offering potential to determine risk stratification, guide targeted monitor treatment response. This review provides an in-depth analysis current landscape biomarkers, highlighting prognostic markers identified We highlighted role including protein, cellular, metabolic, imaging, genetic, epigenetic markers, osteosarcoma categorized them multiple domains. Furthermore, this explores utility canine model research, emphasizing its relevance human due comparable approaches, indicators, clinical manifestations. With review, we aim demonstrate integrating biomarker research species can deepen understanding pathogenesis advance knowledge underlying biology, ultimately paving way precision medicine strategies benefit veterinary oncology.

Язык: Английский

Targeting Oncogenic Signaling Pathways in Lung Cancer: The Emerging Role of Nobiletin, a flavonoid from citrus peel DOI Creative Commons
Newton Suwal, Rajan Thapa,

Saroj Bashyal

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106887 - 106887

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Building a Therapeutic Bridge Between Dogs and Humans: A Review of Potential Cross-Species Osteosarcoma Biomarkers DOI Open Access

Agnieszka Dolnicka,

Vibeke Fosse, Anna Raciborska

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5152 - 5152

Опубликована: Май 28, 2025

Osteosarcoma (OSA) is a naturally occurring malignant bone tumor in both humans and canines that characterized by aggressive local behavior high propensity for metastasis. Despite advances diagnostic methods therapies, long-term survival rates have remained stagnant, underscoring the great need development of biomarkers serving prognosis diagnosis OSA across species. Biomarkers, molecular indicators disease presence or progression, are pivotal tools oncology, offering potential to determine risk stratification, guide targeted monitor treatment response. This review provides an in-depth analysis current landscape biomarkers, highlighting prognostic markers identified We highlighted role including protein, cellular, metabolic, imaging, genetic, epigenetic markers, osteosarcoma categorized them multiple domains. Furthermore, this explores utility canine model research, emphasizing its relevance human due comparable approaches, indicators, clinical manifestations. With review, we aim demonstrate integrating biomarker research species can deepen understanding pathogenesis advance knowledge underlying biology, ultimately paving way precision medicine strategies benefit veterinary oncology.

Язык: Английский

Процитировано

0