The Multifaceted Role of Bilirubin in Liver Disease: A Literature Review

Journal of Clinical and Translational Hepatology, Год журнала: 2024, Номер 000(000), С. 000 - 000

Опубликована: Окт. 21, 2024

Bilirubin, the primary breakdown product of hemoproteins, particularly hemoglobin, plays a key role in diagnosis, prognosis, and monitoring liver diseases. In acute diseases, such as failure, drug-induced injury, viral hepatitis, bilirubin serves biomarker reflecting extent hepatocyte loss damage. Chronic including alcohol-related disease, chronic hepatitis C virus infection, metabolic dysfunction-associated fatty autoimmune are marked by persistent injury inflammation. Bilirubin levels diseases provide insight into function, disease severity, prognosis. As versatile biomarker, offers valuable information on pathophysiology aids guiding clinical decision-making regarding treatment their complications. This review aimed to explore multifunctional analyzing its biological functions beyond

Язык: Английский

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Identification of potential biomarkers for coronary slow flow using untargeted metabolomics

Metabolomics, Год журнала: 2025, Номер 21(1)

Опубликована: Фев. 7, 2025

Язык: Английский

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Elevated plasma soluble lectin-like oxidised low-density lipoprotein receptor 1 as an independent prognostic biomarker in sepsis

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 13, 2025

Язык: Английский

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Bilirubin Metabolism Does Not Influence Serum Bile Acid Profiles According to LC–MS: A Human Case-Control Study

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2475 - 2475

Опубликована: Март 10, 2025

In addition to their role in lipid absorption, bile acids (BAs) are also known for several relevant (endocrine) activities including contributing the regulation of energy homeostasis and some non-communicable diseases (NCDs). Furthermore, moderately elevated unconjugated bilirubin levels, as observed Gilbert’s syndrome (GS), may protect against NCDs. We therefore hypothesized that BA profile GS subjects differs from normo-bilirubinemic individuals. To test this, we performed a human case-control study, which (n = 60) controls were matched age gender, serum concentrations measured by liquid-chromatography mass spectrometry (LC–MS). Despite analyzing comprehensive panel BAs, no significant differences between two groups observed. These data suggest acid similar groups, indicating altered metabolism unlikely influences transport into blood.

Язык: Английский

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Low-Molecular-Weight Compounds Produced by the Intestinal Microbiota and Cardiovascular Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10397 - 10397

Опубликована: Сен. 27, 2024

Cardiovascular disease is the main cause of mortality in industrialized countries, with over 500 million people affected worldwide. In this work, roles low-molecular-weight metabolites originating from gut microbiome, such as short-chain fatty acids, hydrogen sulfide, trimethylamine, phenylacetic acid, secondary bile indoles, different gases, neurotransmitters, vitamins, and complex lipids, are discussed relation to their CVD-promoting or preventing activities. Molecules mixed microbial human hepatic origin, trimethylamine N-oxide phenylacetylglutamine, also presented. Finally, dietary agents cardioprotective effects, probiotics, prebiotics, mono- poly-unsaturated carotenoids, polyphenols, discussed. A special emphasis given microbiota-modulating properties.

Язык: Английский

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Associations between volatile organic compounds exposure and multiple oxidative damage biomarkers: Method development, human exposure, and application for e-waste pollution prediction

The Science of The Total Environment, Год журнала: 2024, Номер 956, С. 177402 - 177402

Опубликована: Ноя. 9, 2024

Язык: Английский

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