Indole 3 carbinol attenuated memory impairment, oxidative stress, inflammation, and apoptosis in bilateral common carotid artery occlusion induced brain damage in rats

3 Biotech, Год журнала: 2025, Номер 15(2)

Опубликована: Янв. 29, 2025

Язык: Английский

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Apigenin-mediated MARK4 inhibition: a novel approach in advancing Alzheimer’s disease therapeutics

Molecular Diversity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer’s disease via the PI3K/Akt pathway

3 Biotech, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 1, 2025

Язык: Английский

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Heavy metal-induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders

BioMetals, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Язык: Английский

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Anti-amyloid β hydrophobic peptides in Alzheimer’s disease: biomarkers and therapeutic potential

Exploration of neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Intracellular amyloid β oligomers (AβOs) have been linked to Alzheimer’s disease (AD) pathogenesis and the neuronal damage in this neurodegenerative disease. Calmodulin, which binds AβO with very high affinity, plays a pivotal role Aβ-induced neurotoxicity has used as model template protein for design of AβO-antagonist peptides. The hydrophobic amino acid residues COOH-terminus domain Aβ play leading its interaction intracellular proteins that bind affinity. This review focuses on Aβ-antagonist peptides their endogenous production brain, highlighting proteasome major source type It is emphasized level these neuropeptides undergoes significant changes brain AD patients relative age-matched healthy individuals. concluded may become helpful biomarkers evaluation risk onset sporadic and/or prognosis AD. In addition, seem priori good candidates development novel therapies, could be combination other drug-based therapies. Future perspectives limitations use clinical management are briefly discussed.

Язык: Английский

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Insights Into the Therapeutic Potential of SIRT1-modifying Compounds for Alzheimer’s Disease: A Focus on Molecular Mechanisms

Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)

Опубликована: Фев. 25, 2025

Язык: Английский

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Mitochondrial Dysfunction in Alzheimer’s Disease

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102713 - 102713

Опубликована: Фев. 1, 2025

Язык: Английский

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Advanced strategies for enhancing the neuroprotective potential of curcumin: delivery systems and mechanistic insights in neurodegenerative disorders

Nutritional Neuroscience, Год журнала: 2025, Номер unknown, С. 1 - 26

Опубликована: Март 3, 2025

Background: Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant neuroprotective potential due to its diverse pharmacological properties.Objective: This review explores curcumin's role in modulating key pathological mechanisms underlying neurodegenerative disorders such as Alzheimer's, Parkinson's diseases, Amyotrophic Lateral Sclerosis, Huntington's Disease and Prion Disease.Methods: A comprehensive analysis of molecular interactions, including effects on amyloid-beta (Aβ) aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, metal-induced neurotoxicity, was conducted. Additionally, strategies overcome low bioavailability blood-brain barrier (BBB) permeability were evaluated.Results: Curcumin inhibits Aβ aggregation promotes disaggregation, reducing amyloid plaque formation Alzheimer's disease. It modulates glial cell activity, attenuating neuroinflammation fostering environment. By interacting with proteins, curcumin prevents hyperphosphorylation neurofibrillary tangle formation. As potent antioxidant, it scavenges reactive oxygen species, mitigating stress-related neuronal damage. Its metal-chelating properties further diminish neurotoxicity by sequestering iron copper ions. Despite limited BBB permeability, therapeutic efficacy can be enhanced using nanocarriers nanoparticles, liposomes, micelles, which improve solubility, stability, brain penetration.Conclusion: Curcumin's multifaceted make promising candidate for preventing or slowing disease progression. Advanced drug delivery systems hold overcoming pharmacokinetic limitations, paving the way future clinical applications.

Язык: Английский

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Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review

Plants, Год журнала: 2025, Номер 14(5), С. 827 - 827

Опубликована: Март 6, 2025

Cruciferae family vegetables are remarkably high in phytochemicals such as Indole-3-carbinol (I3C) and Diindolylmethane (DIM), which widely known nutritional supplements. I3C DIM have been studied extensively different types of cancers like breast, prostate, endometrial, colorectal, gallbladder, hepatic, cervical, well other tissues. In this review, we summarized the protective effects against cardiovascular, neurological, reproductive, metabolic, bone, respiratory, liver, immune diseases, infections, drug- radiation-induced toxicities. Experimental evidence suggests that offer protection due to their antioxidant, anti-inflammatory, antiapoptotic, immunomodulatory, xenobiotic properties. Apart from beneficial effects, present review also discusses possible toxicities reported various preclinical investigations. So far, most reports about diseases only studies; emphasizes dire need for large-scale clinical trials on these human diseases. Further, in-depth research is required improve bioavailability two achieve desirable effects. Overall, our may become potential drug candidates combating dreadful

Язык: Английский

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Epigallocatechin -3- gallate mitigates diazinon neurotoxicity via suppression of pro-inflammatory genes and upregulation of antioxidant pathways

BMC Neuroscience, Год журнала: 2025, Номер 26(1)

Опубликована: Март 10, 2025

Diazinon is a commonly used organophosphate (OP) insecticide especially in developing countries for the control of insect pests, however, exposure to its toxic impact humans and other non-target species remains an important public health concern. The study aimed investigate effect epigallocatechin -3- gallate (EGCG), abundant green tea plants on neurobehavioural, biochemical, pathological changes brain male Wistar rats following diazinon toxicity. Sixty adult were acclimatized seven days subsequently randomly assigned into six treatment groups as follows: Group I: Control group (0.2 mL distilled water); II: at 3 mg/kg (1% LD50); III: (3 mg/kg) + EGCG (50 mg/kg, ~ 2% IV: (100 5% V: VI: mg/kg). All treatments administered orally once daily 14 days. Neurobehavioural studies, biomarkers oxidative stress, histology, immunohistochemistry, quantitative polymerase chain reaction (RT qPCR) performed. alone impaired recognition memory, increased stress markers altered antioxidant defense brain. It upregulated TNF-α IL-6 genes repressed GPx 4 gene expressions. was also associated with GFAP, Tau, α-SN immunoreactivity. Microscopic examination revealed loss Purkinje hippocampal cells Co-treatment however improved cognition, lowered markers, status suppressed IL-6. In conclusion, findings from this demonstrated that offered protection against diazinon-induced neurotoxicity. Hence, natural sources such fruits vegetables could offer immense benefits by protecting inflammation neurodegenerative disease conditions. Clinical trial number Not applicable.

Язык: Английский

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