International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4929 - 4929

Опубликована: Май 21, 2025

Epigenetic dysregulation has emerged as an important player in the pathobiology of neurodegenerative diseases (NDDs), such Alzheimer’s, Parkinson’s, and Huntington’s diseases. Aberrant DNA methylation, histone modifications, dysregulated non-coding RNAs have been shown to contribute neuronal dysfunction degeneration. These alterations are often exacerbated by environmental toxins, which induce oxidative stress, inflammation, genomic instability. Reversing epigenetic aberrations may offer avenue for restoring brain mechanisms mitigating neurodegeneration. Herein, we revisit evidence suggesting ameliorative effects modulators toxin-induced models NDDs. The restoration normal gene expressions, improvement function, reduction pathological markers deacetylase (HDAC) methyltransferase (DNMT) inhibitors demonstrated preclinical Encouragingly, clinical trials Alzheimer’s disease (AD), HDAC caused improvements cognition memory. Combining these beneficial with neuroprotective agents clearance misfolded amyloid proteins synergistic benefits. Reinforced emerging methods more effective brain-specific delivery, reversibility, safety considerations, anticipated minimize systemic toxicity yield favorable outcomes In summary, although still their infancy, integrated strategy address multifactorial nature NDDs, altering therapeutic landscape.

Язык: Английский