Current landscape and future directions of therapeutic approaches for adenoid cystic carcinoma of the salivary glands (Review)

Oncology Letters, Год журнала: 2025, Номер 29(3)

Опубликована: Янв. 22, 2025

Adenoid cystic carcinoma (ACC) of the salivary glands is second most common type gland cancer, and characterized by a poor prognosis an unclear pathology. The incidence ACC rare, as it accounts for 10-15% all tumors affects mainly patients aged between 50 60 years. annual rate estimated to be ~4.5 cases per 100,000 individuals. Due its rarity use contaminated cell lines in previous investigations, precise etiological factors underlying remain poorly understood. Current treatment modalities, typically involving surgery with or without postoperative radiotherapy, often prove unsatisfactory due potential local recurrence delayed distant metastases, which may manifest 3-5 years after constitute primary failure existing therapeutic approaches. indolent growth pattern, along perineural perivascular invasion, potentially responsible onset metastases. No effective systemic therapy has been established so far. Therefore, management represents significant challenge. Exploring molecular characteristics ACC, including reasons behind propensity invasion correlation immune system, offers promising strategies managing could open up novel pathways future interventions. Currently, immunotherapy shown limited effectiveness. While exact mechanism lack response remains unknown, low levels tumor-infiltrating lymphocytes these contribute this resistance. identifying targets enhance against tumor cells essential. present review provides update on clinical studies explores that ACC.

Язык: Английский

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Adenoid cystic carcinoma of the parotid and submandibular glands in children and young adults: A population‐based study

Pediatric Blood & Cancer, Год журнала: 2024, Номер 71(5)

Опубликована: Фев. 28, 2024

This study aims to analyze the behavior and treatment of adenoid cystic carcinoma (AdCC) in pediatric young adult population identify factors affecting overall survival (OS).

Язык: Английский

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Integrating Machine Learning with Web-Based Tools for Personalized Prognosis in Oral Adenoid Cystic Carcinoma

Journal of Stomatology Oral and Maxillofacial Surgery, Год журнала: 2024, Номер unknown, С. 102143 - 102143

Опубликована: Ноя. 1, 2024

Язык: Английский

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Primary adenoid cystic carcinoma of the rib with metastases: A rare case report and literature review

Oncology Letters, Год журнала: 2024, Номер 29(1)

Опубликована: Ноя. 7, 2024

Adenoid cystic carcinoma (ACC) is a rare and aggressive malignant tumour predominantly found in the salivary glands but can also occur elsewhere. Primary ACC bones particularly rare, with most reports focusing on cases of maxilla mandible. This report presents case 47‑year‑old man primary origin right rib region, previously unreported location. Its imaging manifestations pathological features, as well surgical treatment follow‑up, were described to increase awareness this disease.

Язык: Английский

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Salivary adenoid cystic carcinoma-derived α2,6-sialylated extracellular vesicles increase vascular permeability by triggering ER-stress in endothelial cells and promote lung metastasis

Cancer Letters, Год журнала: 2024, Номер unknown, С. 217407 - 217407

Опубликована: Дек. 1, 2024

Язык: Английский

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