Insights into Gut Dysbiosis: Inflammatory Diseases, Obesity, and Restoration Approaches
Andy Acevedo-Román,
Natalia Pagán-Zayas,
Liz I. Velázquez-Rivera
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9715 - 9715
Опубликована: Сен. 8, 2024
The
gut
microbiota
is
one
of
the
most
critical
factors
in
human
health.
It
involves
numerous
physiological
processes
impacting
host
health,
mainly
via
immune
system
modulation.
A
balanced
microbiome
contributes
to
gut’s
barrier
function,
preventing
invasion
pathogens
and
maintaining
integrity
lining.
Dysbiosis,
or
an
imbalance
microbiome’s
composition
disrupts
essential
various
diseases.
This
narrative
review
summarizes
key
findings
related
modern
multifactorial
inflammatory
conditions
such
as
ulcerative
colitis
Crohn’s
disease.
addresses
challenges
posed
by
antibiotic-driven
dysbiosis,
particularly
context
C.
difficile
infections,
development
novel
therapies
like
fecal
transplantation
biotherapeutic
drugs
combat
these
infections.
An
emphasis
given
restoration
healthy
through
dietary
interventions,
probiotics,
prebiotics,
approaches
for
managing
gut-related
Язык: Английский
Green Tea Kombucha Impacts Inflammation and Salivary Microbiota in Individuals with Excess Body Weight: A Randomized Controlled Trial
Nutrients,
Год журнала:
2024,
Номер
16(18), С. 3186 - 3186
Опубликована: Сен. 20, 2024
Background:
Green
tea
kombucha
(GTK)
is
a
fermented
beverage
with
promising
health
benefits,
but
few
studies
proved
its
impact
on
human
health.
Thus,
we
aimed
to
investigate
the
of
GTK
weight
loss,
inflammation,
and
salivary
microbiota
in
individuals
excess
body
weight.
Methods:
This
randomized
controlled
clinical
trial
that
lasted
10
weeks
two
groups
weight:
control
(CG;
n
=
29;
caloric
restriction)
(KG;
30;
restriction
+
200
mL
GTK).
Body
composition,
anthropometry,
saliva,
blood
collection
were
performed
beginning
end
intervention.
Plasma
interleukins
determined
by
flow
cytometry.
Salivary
was
analyzed
16S
rRNA
sequencing.
Results:
Both
decreased
weight,
BMI,
fat
(p
<
0.001)
after
intervention,
there
no
differences
between
groups.
The
KG
reduced
lipid
accumulation
product
(LAP)
0.029).
IL-1β
IL-8,
IL-6
increased
CG
0.023)
compared
group.
Alpha
beta
diversity
KG.
Moreover,
presented
lower
Bacillota/Bacteroidota
ratio
0.028),
BMI
positively
associated
Bacillota
phylum.
Conclusions:
did
not
enhance
it
LAP.
helped
inflammatory
profile
induced
positive
changes
oral
composition.
Язык: Английский
Regular Consumption of Black Tea Kombucha Modulates the Gut Microbiota in Individuals with and Without Obesity
Journal of Nutrition,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
The Impact of Green Tea Kombucha on the Intestinal Health, Gut Microbiota, and Serum Metabolome of Individuals with Excess Body Weight in a Weight Loss Intervention: A Randomized Controlled Trial
Foods,
Год журнала:
2024,
Номер
13(22), С. 3635 - 3635
Опубликована: Ноя. 14, 2024
Green
tea
kombucha
(GTK)
has
emerged
as
a
promising
probiotic
fermented
beverage.
Few
studies
have
investigated
its
effect
on
human
health,
mainly
focusing
intestinal
microbiota
composition,
and
metabolomics.
The
present
study
is
pioneer
in
investigating
the
of
GTK
consumption
individuals
with
excess
body
weight.
This
randomized
controlled
trial,
lasting
ten
weeks,
two
groups
placed
under
an
energy-restricted
diet:
control
(CG,
n
=
29),
(KG,
30;
200
mL/d).
Biological
samples
questionnaires
were
collected
before
after
intervention.
Microbiota
analysis
used
amplification
V4
region
16S
rRNA.
Serum
untargeted
metabolomics
HPLC-TOF
mass
spectrometry.
Intestinal
permeability
considered
urine
excretion
lactulose
mannitol,
plasma
zonulin,
LPS-binding
protein.
After
intervention,
no
differences
related
to
found
between
groups,
but
only
CG
had
increased
fecal
pH,
lactulose/mannitol
ratio,
zonulin.
In
addition
this,
KG
reported
lower
gastrointestinal
symptoms
motility
compared
CG,
discriminant
metabolites
(e.g.,
diethyl
malonate)
strictly
KG.
did
not
significantly
improve
gut
permeability.
However,
ameliorated
positively
influenced
serum
metabolome,
which
may
contribute
enhancing
metabolic
health
Язык: Английский