Fermentation, Год журнала: 2024, Номер 10(8), С. 419 - 419
Опубликована: Авг. 13, 2024
The widespread introduction of antibiotics into medical practice, starting in the late 1940s and early 1950s, radically transformed healthcare, raised it to a qualitatively new level, allowed saving human lives previously hopeless situations, became one most important factors leading an increase life expectancy population Earth by more than 20 years [...]
Язык: Английский
The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174236 - 174236
Опубликована: Июнь 26, 2024
Since the discovery of antibiotics, penicillin has remained top choice in clinical medicine. With continuous advancements biotechnology, production become cost-effective and efficient. Genetic engineering techniques have been employed to enhance biosynthetic pathways, leading new derivatives with improved properties increased efficacy against antibiotic-resistant pathogens. Advances bioreactor design, media formulation, process optimization contributed higher yields, reduced costs, accessibility. While biotechnological advances clearly benefited global this life-saving drug, they also created challenges terms waste management. Production fermentation broths from industries contain residual by-products, other contaminants that pose direct environmental threats, while consumption intensifies risk antimicrobial resistance both environment living organisms. The current geographical spatial distribution antibiotic dramatically reveals a worldwide threat. These are being addressed through development novel management techniques. Efforts aimed at upstream downstream processing minimize costs improve yield efficiency lowering overall impact. Yield using artificial intelligence (AI), along biological chemical treatment waste, is explored reduce adverse impacts. implementation strict regulatory frameworks guidelines essential ensure proper disposal waste. This review because it explores key remaining development, scope machine learning tools such as Quantitative Structure-Activity Relationship (QSAR) modern biotechnology-driven production, for discovering alternative path reducing use agriculture meat addressing practices, offering effective recommendations.
Язык: Английский
Процитировано
5
Metabolic Engineering, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 21 - 64
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 3053 - 3053
Опубликована: Март 6, 2024
The rapid increase in the antibiotic resistance of microorganisms, capable causing diseases humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it necessary to develop fundamentally novel and highly active compounds. study, series N4-alkylcytidines, including 5- 6-methylcytidine derivatives, with extended alkyl substituents, were obtained order new generation antibacterial antifungal biocides based on nucleoside derivatives. It has been shown that N4-alkyl or 6-methylcytidines effectively inhibit growth molds, isolated from paintings halls Ancient Russian Paintings State Tretyakov Gallery, Russia, Moscow. compounds showed activity similar antiseptics commonly used protect works art, such benzalkonium chloride, which number microorganisms have acquired resistance. was also N4-alkylcytidines comparable some antibiotics medicine fight Gram-positive bacteria, resistant strains Staphylococcus aureus Mycobacterium smegmatis. N4-dodecyl-5- turned out be best. This compound seems promising expanding palette painting, since quite often destruction painting materials caused by joint fungi bacteria infection.
Язык: Английский
Процитировано
2
Heritage Science, Год журнала: 2024, Номер 12(1)
Опубликована: Июнь 9, 2024
Abstract The vast majority of cultural heritage objects consist materials that can be subjected to biodeterioration. Currently, there is significant number publications showing which are capable destroying certain organisms, and what conservation restoration procedures required. However, neither a clear classification these diverse events nor their visual representation. In our review, for the first time, an attempt made compare type biodeterioration, based on destruction particular material, with specific color rainbow. this regard, single material designated as one icon; those composite pictogram consisting several icons corresponding colors. For example, stone sculpture, in accordance rainbow code, assigned gray color, was introduced visualize materials. drum corresponds violet (corresponds leather) brown wood). A work easel painting canvas red icon canvas) gold materials). We used cold shades denote basic inorganic materials, organic proposed code biodetermination open platform expanded by adding new colors introduced, allows translate potentially any object into correspond its manufacture. Such graphical interpretation help both systematize storage conditions museum exhibits facilitate understanding processes biodeterioration Graphical
Язык: Английский
Процитировано
1
Applied Biochemistry and Microbiology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 181 - 181
Опубликована: Дек. 28, 2024
From the 1950s to present, main tool for obtaining fungal industrial producers of secondary metabolites remains so-called classical strain improvement (CSI) methods associated with multi-round random mutagenesis and screening level target products. As a result application such techniques, yield in high-yielding (HY) strains was increased hundreds times compared wild-type (WT) parental strains. However, events that occur at molecular during CSI programs are still unknown. In this paper, an attempt made identify characteristic changes genome occurred
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
The biosynthesis of fungal secondary metabolites: from fundamentals to biotechnological applications Evolution-informed discovery the naphthalenone biosynthetic pathway in fungi Functional elucidation Aspergillus parvulus a novel antibiotic compound melleus
Язык: Английский
Процитировано
0
Fermentation, Год журнала: 2024, Номер 10(8), С. 419 - 419
Опубликована: Авг. 13, 2024
The widespread introduction of antibiotics into medical practice, starting in the late 1940s and early 1950s, radically transformed healthcare, raised it to a qualitatively new level, allowed saving human lives previously hopeless situations, became one most important factors leading an increase life expectancy population Earth by more than 20 years [...]
Язык: Английский
Процитировано
0