International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Дек. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140064 - 140064
Опубликована: Янв. 1, 2025
Curcumin,
a
hydrophobic
drug
derived
from
the
rhizome
of
Curcuma
longa,
exhibits
significant
bioactive
properties,
including
antioxidant
and
antimicrobial
potential.
However,
its
poor
water
solubility
rapid
degradation
limit
practical
applications.
This
study
presents
novel
design
electrospun
nanofibers
using
Curcumin/hydroxypropyl-β-cyclodextrin
inclusion
complex
(HP-β-CD-IC)
combined
with
pullulan
to
enhance
thermal
stability
controlled
release.
In
uniaxial
nanofibers,
curcumin/HP-β-CD-IC
is
uniformly
distributed,
whereas
in
coaxial
serves
as
core
material,
wall
material.
X-ray
diffraction
Fourier-transform
infrared
spectroscopy
confirmed
successful
formation,
fibers
showing
no
crystalline
peaks
curcumin.
Differential
scanning
calorimetry
indicated
enhanced
stability,
melting
points
shifting
279.19
°C
291.63
for
fibers,
respectively.
Scanning
electron
microscopy
transmission
verified
core-shell
structure
uniform
morphology.
vitro
release
studies
revealed
that
achieved
higher
cumulative
(93
±
1.41
%)
compared
(80
2.82
over
350
min.
Antibacterial
tests
demonstrated
improved
activity
against
S.
aureus
E.
coli.
Addressing
critical
need
stable
bioavailable
delivery
compounds,
this
innovative
nanofiber
holds
great
promise
revolutionizing
applications
food
technology
delivery.
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown, С. 1 - 20
Опубликована: Янв. 7, 2025
Introduction
The
pursuit
of
linear
dosage
in
pharmacy
is
essential
for
achieving
consistent
therapeutic
release
and
enhancing
patient
compliance.
This
review
provides
a
comprehensive
summary
zero-order
drug
delivery
systems,
with
particular
focus
on
reservoir-based
systems
emanated
from
different
microfabrication
technologies.
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
ABSTRACT
Core‐shell
nanofibers
have
the
potential
to
surpass
traditional
monolithic
electrospun
in
drug
delivery,
due
their
ability
encapsulate
sensitive
therapeutics
within
core,
protect
them
from
degradation,
and
enable
controlled
release
profiles
through
shell.
When
designed
be
stimuli‐responsive,
these
evolve
“smart”
delivery
platforms
for
advanced
therapeutic
applications.
This
mini‐review
examines
recent
advancements
fabrication
applications
of
stimuli‐responsive
core‐shell
nanofibers.
Key
techniques,
such
as
coaxial
electrospinning,
single‐nozzle
electrospinning
using
water‐in‐oil
or
oil‐in‐water
emulsions
immiscible
blends
(e.g.,
polyethylene
oxide
chitosan;
polyvinylpyrrolidone
polyvinylidene),
needleless
post‐fabrication
coating
methods,
are
discussed
along
with
respective
advantages
limitations.
Additionally,
review
also
explores
how
can
engineered
respond
stimuli
like
near‐infrared
(NIR)
light,
ultrasound,
temperature,
pH
changes.
Representative
examples
illustrate
reduce
initial
burst
release,
on‐demand
chemodrug
implement
photothermal
therapy
against
cancer
cells.
At
end,
we
offer
perspectives
on
challenges,
opportunities,
new
directions
future
development.
Beilstein Journal of Nanotechnology,
Год журнала:
2025,
Номер
16, С. 286 - 307
Опубликована: Фев. 26, 2025
This
review
examines
strategies
to
enhance
the
mechanical
properties
of
chitosan/polyvinyl
alcohol
(PVA)
electrospun
nanofibers,
recognized
for
their
biomedical
and
industrial
applications.
It
begins
by
outlining
fundamental
chitosan
PVA,
highlighting
compatibility
characteristics.
The
electrospinning
process
is
discussed,
focusing
on
how
various
parameters
post-treatment
methods
influence
fiber
formation
performance.
Key
improvement
are
analyzed,
including
material
modifications
through
blending
structural
like
orientation
multilayer
constructions,
surface
such
as
coating
functionalization.
also
covers
advanced
characterization
evaluate
provides
a
comparative
analysis
different
enhancement
approaches.
Applications
in
contexts
explored,
showcasing
versatility
innovation
potential
these
nanofibers.
Finally,
current
challenges
addressed,
future
research
directions
proposed
overcome
obstacles
further
chitosan/PVA
guiding
development
practical
Polymers,
Год журнала:
2025,
Номер
17(8), С. 1077 - 1077
Опубликована: Апрель 16, 2025
This
study
investigates
the
preparation
of
electrospun
recycled
polyethylene
terephthalate
(rPET)
coated
with
chitosan
(CS)
and
evaluates
their
antibiofilm
properties
in
vivo
response.
rPET
scaffolds
were
first
fabricated
via
electrospinning
at
different
flow
rates
(10,
7.5,
5
2.5
mL/h)
subsequently
chitosan.
Scanning
electron
microscopy
(SEM)
revealed
that
fiber
morphology
varied
parameters,
influencing
microbial
adhesion.
Antimicrobial
tests
demonstrated
rPET@CS
significantly
inhibited
Staphylococcus
aureus,
Pseudomonas
aeruginosa
Candida
albicans
biofilm
formation
compared
to
control
uncoated
surfaces.
Subcutaneous
implantation
induced
a
transient
inflammatory
response,
macrophage
recruitment
collagen
deposition
supporting
tissue
integration.
These
findings
highlight
potential
as
sustainable
antimicrobial
biomaterials
for
applications
infection-resistant
coatings
biomedical
implants.
