International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Дек. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
Materials,
Год журнала:
2024,
Номер
17(21), С. 5379 - 5379
Опубликована: Ноя. 4, 2024
The
preparation
of
core–sheath
fibers
by
electrospinning
is
a
topic
significant
interest
for
producing
composite
with
distinct
core
and
sheath
functionalities.
Moreover,
in
fibers,
low-molecular-weight
substances
or
nanosized
inorganic
additives
can
be
deposited
targeted
manner
within
the
sheath.
Commonly,
obtaining
structure,
coaxial
used.
It
requires
spinneret
suitable
immiscible
solvents
inner
outer
solutions.
single-nozzle
emulsions
address
these
issues,
but
use
stabilizing
agent
needed.
A
third
approach—preparation
homogeneous
blend
solutions
two
polymers
polymer/low-molecular-weight
substance—has
been
much
less
studied.
circumvents
difficulties
associated
emulsion
thoroughly
discussed
this
review.
formation
case
attributed
to
phase-separation-driven
self-organization
during
process.
Some
possibilities
core–double
using
same
method
are
also
indicated.
gained
knowledge
on
potential
applications
prepared
discussed.
Journal of Industrial Textiles,
Год журнала:
2024,
Номер
54
Опубликована: Янв. 1, 2024
Nanofibrous
scaffolds
offer
significant
promise
for
wound
healing
due
to
their
ability
absorb
exudates,
prevent
microbial
contamination,
and
enhance
oxygen
diffusion.
However,
challenges
remain
in
fully
realizing
clinical
potential,
as
previous
research
has
primarily
focused
on
made
of
two
polymers
or
those
encapsulating
therapeutic
agents
within
nanofibers.
Additionally,
scaling
up
fabrication
while
maintaining
functionality
presents
a
challenge.
This
study
introduces
novel
type
nanofibrous
scaffold,
combining
poly
(ethylene
oxide)
(PEO),
(caprolactone)
(PCL),
chitosan
(CS)
various
mass
ratios,
electrospun
using
Nanospider™
technology.
The
featured
fiber
diameters
ranging
from
134
±
37
148
38
nm
exhibit
high
gram-per-square-meter
values
between
6.8
8.6
g/m
2
.
An
optimal
balance
hydrophilicity
was
achieved,
the
demonstrated
superior
breathability
with
moisture
vapor
transmission
rates
1904.3
28.6
2005.7
42.9
/day,
outperforming
commercial
dressings.
wide
range
hydrolytic
degradation
(3.8
1%
73.2
0.8%),
elongation
at
fracture
(21%
Young’s
modulus
(106.7
8.5
MPa
170.7
11.9
MPa)
were
observed.
Surface-immobilized
tetracycline
(TET)
significantly
enhanced
antibacterial
efficacy,
inhibition
zones
exceeding
20
mm
against
Escherichia
coli.
Our
findings
confirm
that
scaffold
properties
can
be
effectively
tailored
by
adjusting
PEO/PCL
ratio,
advancing
customization
care.
Post-fabrication
soaking
TET
solutions
further
boosts
performance
allows
post-production
adjustments.
Compared
existing
studies,
this
approach
simplifies
improves
practicality
care
solutions.
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Дек. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
