Polystyrene nanoplastics exacerbate gentamicin-induced nephrotoxicity in adult rat by activating oxidative stress, inflammation and apoptosis pathways

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Язык: Английский

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Toxicological assays and metabolomic profiling to evaluate the effects of virgin and aged micro- and nano- polystyrene plastics in SH-SY5Y human neuroblastoma cells

The Science of The Total Environment, Год журнала: 2025, Номер 975, С. 179262 - 179262

Опубликована: Март 31, 2025

Язык: Английский

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Metabolomic and biochemical disorders reveal the toxicity of environmental microplastics and benzo[a]pyrene in the marine polychaete Hediste diversicolor

Journal of Hazardous Materials, Год журнала: 2024, Номер 477, С. 135404 - 135404

Опубликована: Авг. 2, 2024

Язык: Английский

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Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12166 - 12166

Опубликована: Ноя. 13, 2024

The widespread use of plastics has increased environmental pollution by micro- and nanoplastics (MNPs), especially polystyrene (PS-MNPs). These particles are persistent, bioaccumulative, linked to endocrine-disrupting toxicity, posing risks reproductive health. This review examines the effects PS-MNPs on mammalian systems, focusing oxidative stress, inflammation, hormonal imbalances. A comprehensive search in Web Science Core Collection, following PRISMA 2020 guidelines, identified studies impact fertility, including oogenesis, spermatogenesis, folliculogenesis. An analysis 194 publications revealed significant harm, such as reduced ovarian size, depleted follicular reserves, apoptosis somatic cells, disrupted estrous cycles females, along with impaired sperm quality imbalances males. were endocrine disruption, leading cellular molecular damage. Further research is urgently needed understand toxicity mechanisms, develop interventions, assess long-term health impacts across generations, highlighting need address these challenges given growing exposure.

Язык: Английский

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Toxicity assessment of animal manure composts containing environmental microplastics by using earthworms Eisenia andrei

The Science of The Total Environment, Год журнала: 2024, Номер 931, С. 172975 - 172975

Опубликована: Май 3, 2024

Nowadays, animal manure composting constitutes a sustainable alternative for farmers to enhance the level of nutrients within soils and achieve good productivity. However, pollutants may be present in manures. This study focuses on detection environmental microplastics (EMPs) into composts, as well assessment their potential toxicity earthworm Eisenia andrei. To these aims, animals were exposed two types compost, namely bovine (cow) ovine (sheep) manure, besides mixture, 7 14 days. The presence characterization EMPs was evaluated all tested tissues earthworms. impact composts assessed by multi-biomarker approach including cytotoxic (lysosomal membrane stability, LMS), genotoxic (micronuclei frequency, MNi), biochemical (activity catalase, CAT, glutathione-S-transferase, GST; content malondialdehyde, MDA), neurotoxic acetylcholinesterase, AChE) responses Results indicated high levels especially sheep (2273.14 ± 200.89 items/kg) comparison cow (1628.82 175.23 items/kg), with size <1.22 μm most abundant EMPs. A time-dependent decrease LMS AChE noted earthworms, concomitant increase DNA damages (MNi) after days exposure. Also, severe oxidative stress recorded treated different compost through an CAT GST activities, LPO levels, Therefore, it is necessary carefully consider findings agricultural practices terms plastic mitigation usage, order prevent any risk environment health.

Язык: Английский

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A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review

The Science of The Total Environment, Год журнала: 2024, Номер 932, С. 172915 - 172915

Опубликована: Май 6, 2024

The increasing trend regarding the use of plastics has arisen an exponential concern on fate their derived products to environment. Among these derivatives, microplastics and nanoplastics (MNPs) have been featured for associated environmental impact due low molecular size high surface area, which prompted ubiquitous transference among all interfaces. Due heterogenous chemical composition MNPs, study particles focused a number studies, as result myriad physicochemical properties that contribute co-transference wide range contaminants, thus becoming major challenge scientific community. In this sense, both primary secondary MNPs are well-known be adscribed industrial urbanized areas, from they massively released environment through multiscale level, involving atmosphere, hydrosphere, lithosphere. Consequently, much research conducted understanding interconnection between those interfaces, motivate spread contaminants biological systems, being mostly represented by biosphere, especially phytosphere and, finally, anthroposphere. These findings highlighted potential hazardous risk human health different mechanisms environment, requiring deeper approach define real exposure. As result, there is gap knowledge high-throughput perspective. review, metabolomics-based overview interfaces was proposed, considering technology highly valuable tool decipher opening novel perspective contaminants.

Язык: Английский

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Type-specific inflammatory responses of vascular cells activated by interaction with virgin and aged microplastics

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 282, С. 116695 - 116695

Опубликована: Июль 8, 2024

Язык: Английский

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Abundance and distribution of environmental microplastic in edible fish and mussels from the south Mediterranean coasts

Marine Pollution Bulletin, Год журнала: 2024, Номер 206, С. 116705 - 116705

Опубликована: Июль 23, 2024

Язык: Английский

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Synergistic effects between microplastics and glyphosate on honey bee larvae

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 111, С. 104550 - 104550

Опубликована: Сен. 7, 2024

Язык: Английский

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Toxicity of polystyrene nanoplastic and copper oxide nanoparticle in Artemia salina: single and combined effects on stress responses

Marine Environmental Research, Год журнала: 2024, Номер 203, С. 106831 - 106831

Опубликована: Ноя. 8, 2024

Язык: Английский

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