Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(32), С. 11894 - 11918
Опубликована: Авг. 10, 2023
AbstractPlant-derived
polyphenols
are
naturally
occurring
compounds
widely
distributed
in
plants.
They
have
received
greater
attention
the
food
and
pharmaceutical
industries
due
to
their
potential
health
benefits,
reducing
risk
of
some
chronic
diseases
antioxidant,
anti-inflammatory,
anticancer,
cardioprotective,
neuro-action
properties.
Polyphenolic
orally
administered
can
be
used
as
adjuvants
several
treatments
but
with
restricted
uses
chemical
instability.
The
review
discusses
different
structural
compositions
influence
on
stability.
Despite
wide
applications,
there
is
a
need
improve
delivery
polyphenolics
target
human
intestine
without
massive
modifications.
Oral
administration
unfeasible
instability,
low
bioaccessibility,
limited
bioavailability.
Nano-delivery
systems
based
polysaccharides
(starch,
pectin,
chitosan,
cellulose)
been
identified
viable
option
for
oral
ingestion,
potentiate
biological
effects,
direct-controlled
specific
tissues.
time
dose
individualized
diseases,
such
intestinal
cancer.
This
will
address
mechanisms
by
which
polysaccharides-based
nanostructured
protect
against
degradation
enhance
permeation,
bioavailability,
application
nanocarriers
controlled
targeted
polyphenolic
compounds.Keywords:
Antioxidantsbioavailabilityflavonoidsnanoencapsulationpolyphenolic
compoundspolysaccharidestarget
Disclosure
statementThe
authors
declare
no
conflicts
interest.Author
contributionsT.K.O.R.:
Conceptualization,
data
curation,
writing
(original
draft
editing);
F.F.A.S.:
(review
E.S.B:
J.P.F.:
conceptualization,
supervision,
editing).
All
read
agreed
published
version
manuscript.Additional
informationFundingThe
acknowledge
National
Council
Scientific
Technological
Development
(CNPq)
T.K.O.R.
scholarship
(#151150/2023-0)
J.P.F.
productivity
(#307842/2022-3).
São
Paulo
Research
Foundation
(FAPESP)
(#2023/09620-3).
study
was
financially
supported
grants
#2013/07914-8,
#2022/12834-2
#2023/01396-7
from
(FAPESP).
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
318, С. 102957 - 102957
Опубликована: Июнь 27, 2023
Enzymes
are
widely
used
in
industry
due
to
their
high
efficiency
and
selectivity.
However,
low
stability
during
certain
industrial
processes
can
result
a
significant
loss
of
catalytic
activity.
Encapsulation
is
promising
technique
that
stabilize
enzymes
by
protecting
them
from
environmental
stresses
such
as
extreme
temperature
pH,
mechanical
force,
organic
solvents,
proteases.
Alginate
alginate-based
materials
have
emerged
effective
carriers
for
enzyme
encapsulation
biocompatibility,
biodegradability,
ability
form
gel
beads
through
ionic
gelation.
This
review
presents
various
systems
stabilization
explores
applications
different
industries.
We
discuss
the
preparation
methods
alginate
encapsulated
analyze
release
mechanisms
materials.
Additionally,
we
summarize
characterization
techniques
enzyme-alginate
composites.
provides
insights
into
use
means
stabilizing
highlights
potential
benefits
applications.
A
method
for
the
synthesis
of
ZnO
nanoparticles
(ZnO
NPs)
gels
was
developed.
NPs
were
obtained
through
a
sol-gel
with
zinc
acetate
usage
as
precursor.
Optimization
gel
has
been
carried
out.
It
observed
that
most
stable
are
formed
at
room
temperature,
pH
=
8
and
molar
concentration
C(Zn2+)
0.05-0.2
M.
shown
addition
polysaccharide
significantly
affects
rheological
properties
microstructure
gels.
We
found
optimal
is
hydroxyethyl
cellulose.
stabilized
cellulose
represented
by
irregularly
shaped
particles
assembled
into
aggregates,
sizes
ranging
from
150
to
1400
nm.
significant
hysteresis
region
in
The
process
interaction
polysaccharides
investigated.
occurs
charged
hydroxyl
group.
In
experiment,
sample
modified
tested.
pronounced
regenerative
effect
on
burn
wounds,
which
higher
than
control
group
treated
microparticles
(MPs)
also
rate
healing
wounds
animals
(group
3)
16.23%
2),
24.33%
average
entire
experimental
period
3
1.26
1.54
times
2
group,
respectively.
An
study
effectiveness
its
use
modeling
skin
primary
tension.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 22
Опубликована: Фев. 7, 2025
Anthocyanins
are
natural
flavonoids
derived
from
plants,
widely
recognized
for
their
health-promoting
effects,
specifically
to
treat
inflammatory
bowel
disease
(Crohn's
and
ulcerative
colitis).
However,
certain
limitations
associated
with
use,
including
instability,
low
solubility
permeability,
poor
gastrointestinal
digestion,
bioavailability.
In
this
review,
nano-carriers
(e.g.,
liposome,
polymersome,
exosome,
halloysite
nanotubes,
dendrimer,
nano-niosome,
etc.)
were
summarized
as
anthocyanins
delivery
vehicles
disease.
Recent
progress
on
emerging
strategies
involved
surface
functionalization,
responsive
release,
magnetic
orientation,
self-assembly
aggregation
address
intestinal
inflammation
through
potential
mechanisms
discussed.
Anthocyanins,
water-soluble
pigments
linked
by
glycoside
bonds
have
attracted
attention
alleviate
related
diseases.
can
exerting
health
beneficial
effects
such
anti-oxidative,
anti-inflammatory,
regulating
the
flora,
promoting
apoptosis.
Moreover,
discussed
oral
system
maximized
bioefficacy
of
concerns
metabolism,
bioavailability
A
future
perspective
is
proposed
concerning
anthocyanin-loaded
nano-carriers,
different
improve
efficacy,
developing
functional
food
inflammation.
Molecules,
Год журнала:
2022,
Номер
28(1), С. 158 - 158
Опубликована: Дек. 24, 2022
Medicinal
plants
are
rich
sources
of
valuable
molecules
with
various
profitable
biological
effects,
including
antimicrobial
activity.
The
advantages
herbal
products
their
effectiveness,
relative
safety
based
on
research
or
extended
traditional
use,
and
accessibility
without
prescription.
Extensive
irrational
usage
antibiotics
since
discovery
in
1928
has
led
to
the
increasing
expiration
effectiveness
due
antibacterial
resistance.
Now,
medical
is
facing
a
big
challenging
mission
find
effective
safe
therapies
replace
inactive
drugs.
Over
years,
one
fields
that
remained
most
available
area
natural
products:
medicinal
metabolites,
which
could
serve
as
active
substances
fight
against
microbes
be
considered
models
drug
design.
This
review
presents
selected
flavonoids
(such
apigenin,
quercetin,
kaempferol,
kurarinone,
morin)
tannins
(including
oligomeric
proanthocyanidins,
gallotannins,
ellagitannins,
catechins,
epigallocatechin
gallate),
but
also
these
compounds
potential
therapeutic
agents
oral
infectious
diseases
usages
such
Agrimonia
eupatoria
L.,
Hamamelis
virginiana
Matricaria
chamomilla
Vaccinium
myrtillus
Quercus
robur
Rosa
gallica
Rubus
idaeus
Potentilla
erecta
(L.).
Some
presented
extracts
already
successfully
used
maintain
health,
main
additive
ingredient
toothpastes
mouthwashes.
Others
promising
for
further
future
applications.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Фев. 4, 2022
Flavonoids
isolated
from
medicinal
herbs
have
been
utilized
as
valuable
health-care
agents
due
to
their
virous
biological
applications.
Alpinetin
is
a
natural
flavonoid
that
emerges
in
many
widely
used
plants,
and
has
frequently
applied
Chinese
patent
drugs.
Accumulated
evidence
demonstrated
alpinetin
possesses
broad
range
of
pharmacological
activities
such
antitumor,
antiinflammation,
hepatoprotective,
cardiovascular
protective,
lung
antibacterial,
antiviral,
neuroprotective,
other
properties
through
regulating
multiple
signaling
pathways
with
low
systemic
toxicity.
However,
pharmacokinetic
studies
documented
may
poor
oral
bioavailability
correlated
its
extensive
glucuronidation.
Currently,
the
reported
pharmacokinetics
profiles
are
rare
be
scientifically
reviewed.
In
this
article,
we
aimed
highlight
mechanisms
action
various
diseases
strongly
support
curative
potentials
for
prospective
clinical
We
also
summarized
proposed
some
viable
strategies
convey
an
appreciable
reference
future
advances
drug
development.
