Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 21

Опубликована: Сен. 6, 2022

Plant preparations have been used to treat various diseases and discussed for centuries. Research has advanced discover identify the plant components with beneficial effects reveal their underlying mechanisms. Flavonoids are phytoconstituents anti-inflammatory, antimutagenic, anticarcinogenic, antimicrobial properties. Herein, we listed contextualized aspects of protective flavonols quercetin, isoquercetin, kaempferol, myricetin flavones luteolin, apigenin, 3',4'-dihydroxyflavone, baicalein, scutellarein, lucenin-2, vicenin-2, diosmetin, nobiletin, tangeretin, 5-O-methyl-scutellarein. We presented structural characteristics subclasses, importance, occurrence, food sources. The bioactive compounds present in our diet, such as fruits vegetables, may affect health disease state. Therefore, role these inflammation, oxidative mechanisms, bacterial metabolism; moreover, synergism antibiotics better outcomes. Indiscriminate use allows emergence multidrug-resistant strains; thus, be adjuvant treatment infectious caused by resistant opportunistic bacteria via direct indirect also focused on reported mechanisms intracellular targets flavones, which support therapeutic inflammatory diseases.

Язык: Английский

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Research Progress on Extraction and Detection Technologies of Flavonoid Compounds in Foods

Foods, Год журнала: 2024, Номер 13(4), С. 628 - 628

Опубликована: Фев. 19, 2024

Flavonoid compounds have a variety of biological activities and play an essential role in preventing the occurrence metabolic diseases. However, many structurally similar flavonoids are present foods usually low concentrations, which increases difficulty their isolation identification. Therefore, developing optimizing effective extraction detection methods for extracting from food is essential. In this review, we review structure, classification, chemical properties flavonoids. The research progress on recent years comprehensively summarized, as application mathematical models experimental conditions. results provide theoretical basis technical support detecting analyzing high-purity foods.

Язык: Английский

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Exploring the bioaccessibility and intestinal absorption of major classes of pure phenolic compounds using in vitro simulated gastrointestinal digestion

Heliyon, Год журнала: 2024, Номер 10(7), С. e28894 - e28894

Опубликована: Март 27, 2024

The bioaccessibility and bioavailability of phenolic compounds (PC) influence directly their role in disease prevention/control.Studies have evaluated this ability through complex plant food matrices, which may reflect more a synergistic effect the matrix than PCs, hindering individual exploitation nutraceutical or pharmaceutical applications.In present study ten pure PCs representing major classes were for intestinal absorption an vitro simulated gastrointestinal digestion (SGD).This is first concerning evaluation phloretin, phloroglucinol, naringin, naringenin daidzein, while no SGD has been performed before other considered here.PCs analyzed ultra-high-performance liquid chromatography coupled with diode-array detection tandem mass spectrometry (UHPLC-DAD-MS n ).Most remained along tract, was general higher 50%, except quercetin, epigallocatechin gallate, ellagic acid.All highly absorbed intestine, phloretin showing lowest percentage at about 82%.The findings provide new knowledge on different classes.

Язык: Английский

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Phenolic Compound Profile and Antioxidant Capacity of Flax (Linum usitatissimum L.) Harvested at Different Growth Stages

Molecules, Год журнала: 2023, Номер 28(4), С. 1807 - 1807

Опубликована: Фев. 14, 2023

The profile of phenolic compounds changes during the growth a plant and this change affects its antioxidant potential. aim research has been to find stage flax with highest capacity, determine responsible for such capacity. Flax was harvested in six stages: from stem extension mature seeds. were identified using LC-TOF-MS quantified an extract fresh matter (FM) each stage. radical scavenging activity against ABTS•+ DPPH•, ferric-reducing power (FRAP), β-carotene-linoleic acid emulsion system determined. Mono- di-C-glycosyl flavones found be most abundant phenolics aerial parts flax, which also showed content isoorientin (210-538 µg/g FM). Coniferin, derivative, hydroxycinnamic derivatives detected. richer flavone C-glycosides seed ripening (1105-1413 FM) than at (557 Most individual C-glycoside contents extracts decreased when increasingly older plants considered; however, did not significantly steam stages. antiradical FRAP higher flowering, brown capsule, stages, mainly due presence C-glycosides. oxidation instead inhibited more effectively by capsule Coniferin derivative involved activity. flowering could valuable source use as nutraceuticals components functional foods.

Язык: Английский

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Recent advances in understanding dietary polyphenols protecting against hypertension

Trends in Food Science & Technology, Год журнала: 2023, Номер 138, С. 685 - 696

Опубликована: Июль 17, 2023

Язык: Английский

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Evaluation of the antioxidant potential of brown seaweeds extracted by different solvents and characterization of their phenolic compounds by LC–ESI‐QTOF–MS/MS

Journal of Food Science, Год журнала: 2023, Номер 88(9), С. 3737 - 3757

Опубликована: Авг. 2, 2023

Abstract Seaweeds, serving as valuable natural sources of phenolic compounds (PCs), offer various health benefits like antioxidant, anti‐inflammatory properties, and potential anticancer effects. The efficient extraction PCs from seaweed is essential to harness their further applications. This study compares the effectiveness different solvents (ethanol, methanol, water, acetone, ethyl acetate) for extracting four species: Ascophyllum sp., Fucus Ecklonia Sargassum sp. Among them, ethanol extract had highest content total phenolics (25.33 ± 1.45 mg GAE/g) demonstrated potent scavenging activity against 2,2‐diphenyl‐1‐picrylhydrazyl radical (33.65 0.03 TE/g) phosphomolybdate reduction (52.98 0.47 TE/g). flavonoids (0.40 0.02 QE/g) in its methanol extract, whereas acetate contained condensed tannins (8.09 0.12 CE/g). relatively strong antioxidant activity, with methanolic extracts exhibiting a ability 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (54.41 0.24 water showing ferric‐reducing power 36.24 0.06 TE/g. Likewise, liquid chromatography–mass spectrometry identified 61 individual PCs, including 17 acids, 32 flavonoids, 12 other polyphenols. particularly exhibited most diverse composition. These findings underscore importance selecting appropriate based on specific species desired compounds, providing guidance pharmaceutical, nutraceutical, cosmetic industries. Practical Application which are secondary metabolites present terrestrial plants marine organisms, have garnered considerable attention due advantages biological Using organic/inorganic during process makes it possible selectively isolate types species. distinct polarity solubility properties each solvent enable facilitating comprehensive assessment composition found samples guiding industrial production.

Язык: Английский

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Supercritical CO2 extraction of naringenin from Mexican oregano (Lippia graveolens): its antioxidant capacity under simulated gastrointestinal digestion

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 11, 2024

Abstract A supercritical CO 2 method was optimized to recover naringenin-rich extract from Mexican oregano ( Lippia graveolens ), a flavanone with high antioxidant and anti-inflammatory activity. The effect of the extraction parameters like pressure, temperature, co-solvent on naringenin concentration evaluated. We used response surface methodology optimize oregano; chemical composition by UPLC-MS simulated gastrointestinal digestion its capacity total phenolic content were also optimum conditions 58.4 °C 12.46% (ethanol), pressure 166 bar, obtaining 46.59 mg/g extract. Also, extracts yielded quantities cirsimaritin, quercetin, phloridzin, apigenin, luteolin. results indicated that obtained at had higher content, TEAC ORAC, flavonoid compared methanolic extract, reduced all these values.

Язык: Английский

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Comparison of the inhibition effects of naringenin and its glycosides on LPS-induced inflammation in RAW 264.7 macrophages

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Янв. 2, 2024

Язык: Английский

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Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(41), С. 14890 - 14910

Опубликована: Окт. 6, 2023

Flavonoids and their glycosides are abundant in many plant-based foods. The (de)glycosylation of flavonoids by retaining glycoside hydrolases has recently attracted much interest basic applied research, including the possibility altering glycosylation pattern flavonoids. Research this area is driven significant differences physicochemical, organoleptic, bioactive properties between flavonoid aglycones glycosylated counterparts. While present nature at low levels, some occur substantial quantities, making them readily available low-cost glycosyl donors for transglycosylations. Retaining glycosidases can be used to synthesize natural novel glycosides, which serve as standards bioactivity experiments analyses, using donors. Engineered also prove valuable synthesis chemically synthesized activated This review outlines bioactivities highlights applications context acting substrates, products, or deglycosylation transglycosylation reactions.

Язык: Английский

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Research of saccharides and related biocomplexes: A review with recent techniques and applications

Journal of Separation Science, Год журнала: 2024, Номер 47(9-10)

Опубликована: Май 1, 2024

Saccharides and biocompounds as saccharide (sugar) complexes have various roles biological functions in living organisms due to modifications via nucleophilic substitution, polymerization, complex formation reactions. Mostly, mono‐, di‐, oligo‐, polysaccharides are stabilized inactive glycosides, which formed metabolic pathways. Natural saccharides important food environmental monitoring. Glycosides with functionalities significant clinical medical research. often studied the chromatographic methods of hydrophilic interaction liquid chromatography anion exchange chromatograpy, but also capillary electrophoresis mass spectrometry their on‐line coupling systems. Sample preparation is identification compounds. The cases discussed here focus on bioscience, clinical, applications.

Язык: Английский

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