Effects of Pueraria lobata root and Glycine max (L.) Merrill extracts fermented with Lactiplantibacillus plantarum on the depressive-like behavior in ovariectomized mice via upregulation of hippocampal BDNF DOI Creative Commons
Jimyeong Ha,

Hyo‐Min Jang,

In-Suk Choi

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 108, С. 105776 - 105776

Опубликована: Сен. 1, 2023

Pueraria lobata roots and Glycine max (L.) Merrill are rich in isoflavones, which phytoestrogens known to alleviate menopausal some disease symptoms. However, the high molecular weight poor bioavailability of owing glucose moieties attached these glycosides, limit their practical use. Fermentation with lactic acid bacteria has been reported convert glycosides into aglycone forms. In this study, we investigated health-promoting effects fermented P. root extract (FPE) G. (FGE) using ovariectomized mice. The was bacteria. Lactiplantibacillus plantarum strains that aglycones were selected, vitro vivo experiments conducted confirm various functionalities resulting from fermentation. FPE FGE exhibited estrogen-like activities. particular, fermentation increased expression estrogen receptor beta (ERβ), as a result extracts should probably not be associated increasing incidence female cancers—a common side effect hormone replacement therapy. addition, oral administration FPE, FGE, or mixture two (FPE-FGE) mice improved depressive symptoms by upregulating hippocampal brain-derived neurotrophic factor (BDNF). ERβ highest FPE-FGE group. These results indicate can used raw material for development dietary supplements women because it increases alleviates depressive-like behavior through regulation BDNF neurotransmitters.

Язык: Английский

Exploring the Fermentation-Driven Functionalities of Lactobacillaceae-Originated Probiotics in Preventive Measures of Alzheimer’s Disease: A Review DOI Creative Commons
Anjali Tripathi, Vinay Kumar Pandey, V. Tiwari

и другие.

Fermentation, Год журнала: 2023, Номер 9(8), С. 762 - 762

Опубликована: Авг. 16, 2023

Alzheimer’s disease (AD) is an ascending, neurodegenerative disorder that attacks the brain’s nerve cells, i.e., neurons, resulting in loss of memory, language skills, and thinking behavioural changes. It one most common causes dementia, a group disorders marked by decline cognitive functioning. Probiotics are living microorganisms beneficial for human well-being. They help balancing extent bacteria gut support defensive immune system body. Studies have found probiotics can with variety conditions, including mental health. to maintain strengthen healthy microbiome. The microbiome important brain function, as it linked production neurotransmitters hormones regulate mood behaviour. This review article includes detailed on origination its significance treatment AD.

Язык: Английский

Процитировано

1
Effects of Pueraria lobata root and Glycine max (L.) Merrill extracts fermented with Lactiplantibacillus plantarum on the depressive-like behavior in ovariectomized mice via upregulation of hippocampal BDNF DOI Creative Commons
Jimyeong Ha,

Hyo‐Min Jang,

In-Suk Choi

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 108, С. 105776 - 105776

Опубликована: Сен. 1, 2023

Pueraria lobata roots and Glycine max (L.) Merrill are rich in isoflavones, which phytoestrogens known to alleviate menopausal some disease symptoms. However, the high molecular weight poor bioavailability of owing glucose moieties attached these glycosides, limit their practical use. Fermentation with lactic acid bacteria has been reported convert glycosides into aglycone forms. In this study, we investigated health-promoting effects fermented P. root extract (FPE) G. (FGE) using ovariectomized mice. The was bacteria. Lactiplantibacillus plantarum strains that aglycones were selected, vitro vivo experiments conducted confirm various functionalities resulting from fermentation. FPE FGE exhibited estrogen-like activities. particular, fermentation increased expression estrogen receptor beta (ERβ), as a result extracts should probably not be associated increasing incidence female cancers—a common side effect hormone replacement therapy. addition, oral administration FPE, FGE, or mixture two (FPE-FGE) mice improved depressive symptoms by upregulating hippocampal brain-derived neurotrophic factor (BDNF). ERβ highest FPE-FGE group. These results indicate can used raw material for development dietary supplements women because it increases alleviates depressive-like behavior through regulation BDNF neurotransmitters.

Язык: Английский

Процитировано

1