Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(47), С. 26007 - 26026
Опубликована: Окт. 15, 2024
Collagen
peptides
have
been
reported
to
display
various
bioactivities
and
high
bioavailability.
Recently,
increasing
evidence
has
revealed
the
excellent
wound-healing
activity
of
collagen
peptides,
but
their
molecular
mechanisms
remain
incompletely
elucidated.
This
review
systematically
evaluates
therapeutic
efficacy
from
diverse
sources
based
on
wound
models.
Furthermore,
structure-activity
relationships
are
discussed
summarized.
Characterized
by
low
weight
abundant
imino
acids,
facilitate
efficient
absorption
body
deliver
nutrition
throughout
process.
The
specific
mechanism
peptide
for
healing
is
mainly
through
up-regulation
related
cytokines
participation
in
activation
relevant
signaling
pathways,
such
as
TGF-β/Smad
PI3K/Akt/mTOR,
which
can
promote
cell
proliferation,
angiogenesis,
synthesis
deposition,
re-epithelialization,
ECM
remodeling,
ultimately
achieving
effect
healing.
offer
a
potential
approach
treating
incision
excision
wounds,
mucosal
injuries,
burn
pressure
ulcers,
improving
efficiency
about
10%-30%.
present
contributes
understanding
underlying
mechanisms.
Fermentation,
Год журнала:
2024,
Номер
10(6), С. 315 - 315
Опубликована: Июнь 14, 2024
The
global
food
production
system
faces
several
challenges,
including
significant
environmental
impacts
due
to
traditional
agricultural
practices.
rising
demands
of
consumers
for
products
that
are
safe,
healthy,
and
have
animal
welfare
standards
led
an
increased
interest
in
alternative
proteins
the
development
cellular
agriculture
field.
Within
this
innovative
field,
precision
fermentation
has
emerged
as
a
promising
technological
solution
produce
with
reduced
ecological
footprints.
This
review
provides
summary
related
current
production,
explores
how
can
contribute
address
these
issues.
Additionally,
we
report
on
main
animal-derived
produced
by
fermentation,
particular
focus
those
used
nutraceutical
industries.
general
principles
will
be
explained,
strain
bioprocess
optimization.
Examples
efficient
recombinant
protein
bacteria
yeasts,
such
milk
proteins,
egg-white
structural
flavoring
also
addressed,
along
case
examples
companies
producing
at
commercial
scale.
Through
examples,
explore
supports
sustainable
holds
potential
innovations
sector.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
278, С. 134374 - 134374
Опубликована: Авг. 3, 2024
The
consumption
of
animal
products
has
witnessed
a
significant
increase
over
the
years,
leading
to
growing
need
for
industries
adopt
strict
waste
control
measures
mitigate
environmental
impacts.
disposal
in
landfill
can
result
diverse
and
potentially
hazardous
decomposition
by-products.
Animal
by-products,
derived
from
meat,
poultry,
seafood
fish
industries,
offer
substantial
raw
material
source
collagen
gelatin
production
due
their
high
protein
content.
Collagen,
being
major
component
tissues,
represents
an
abundant
resource
that
finds
application
various
chemical
industries.
demand
collagen-based
continues
grow,
yet
availability
primary
remains
limited
insufficient
meet
projected
needs.
Consequently,
repurposing
materials
contain
provides
opportunity
this
while
at
same
time
minimizing
amount
is
dumped.
This
review
examines
potential
extract
value
content
present
animal-derived
It
systematic
evaluation
different
species
groups
discusses
approaches
processing
fabricating
repurposed
collagen.
specifically
focuses
on
research,
encompassing
examination
its
physical
properties,
as
well
modifications.
We
have
detailed
how
research
knowledge
built
structure
function
will
drive
new
initiatives
lead
development
opportunities
future.
Additionally,
it
highlights
emerging
extracting
high-quality
efforts
fabricate
original
within
chemical,
biomedical
science-based
Marine Drugs,
Год журнала:
2023,
Номер
21(12), С. 605 - 605
Опубликована: Ноя. 23, 2023
Chitin/chitosan
and
collagen
are
two
of
the
most
important
bioactive
compounds,
with
applications
in
pharmaceutical,
veterinary,
nutraceutical,
cosmetic,
biomaterials,
other
industries.
When
extracted
from
non-edible
parts
fish
shellfish,
by-catches,
invasive
species,
their
use
contributes
to
a
more
sustainable
circular
economy.
The
present
article
reviews
scientific
knowledge
publication
trends
along
marine
chitin/chitosan
value
chains
assesses
how
researchers,
industry
players,
end-users
can
bridge
gap
between
understanding
industrial
applications.
Overall,
research
on
remains
focused
compound
itself
rather
than
its
market
Still,
is
expected
increase
food
biomedical
applications,
while
that
biomedical,
nutritional
Sustainable
practices,
such
as
reuse
waste
materials,
contribute
strengthen
both
chains;
identified
weaknesses
include
lack
studies
considering
trends,
social
sustainability,
profitability,
well
insufficient
examination
intellectual
property
rights.
Government
regulations,
demand,
consumer
preferences,
technological
advancements,
environmental
challenges,
legal
frameworks
play
significant
roles
shaping
chains.
Addressing
these
factors
crucial
for
seizing
opportunities,
fostering
complying
maintaining
competitiveness
constantly
evolving
Intelligent Pharmacy,
Год журнала:
2024,
Номер
2(4), С. 456 - 466
Опубликована: Май 16, 2024
Cowhide
collagen
hydrolysates
(CCHs)
are
peptides
and
amino
acids
obtained
from
the
partial
hydrolysis
of
collagen.
These
have
numerous
potential
applications
in
food,
biomedical,
pharmaceutical
industries.
The
study
analyzed
physicochemical,
antioxidant,
anti-atherosclerosis
properties
cowhide
using
silico
methods.
Proteins
were
identified
based
on
their
molecular
weights
origin
protein
database
(UniProtKB).
Using
bioinformatics
tools,
physicochemical
(toxicity
acid
composition)
determined.
proteins
subsequently
subjected
to
an
enzymatic
pepsin,
thermolysin,
proteinase
K.
characterized.
Molecular
docking
was
conducted
between
generated
three
target
enzymes
(3-Hydroxy-3-Methylglutaryl-CoA
(HMG-CoA)
reductase,
cyclooxygenase-2,
Nicotinamide
Adenine
Dinucleotide
Phosphate
(NADPH)
oxidase).
Two
collagens
identified,
F1MJQ6
G3MZI7,
with
172,076
184,867
Dalton,
respectively.
A
compositional
analysis
G3MZI7
revealed
significant
presence
glycine
residues
at
25%
23%,
proline
16%
18%,
exhibited
a
high
concentration
both
essential
semi-essential
acids.
results
indicate
that
antioxidant
ADF,
PHF,
LW
(novel
released
by
K)
most
promising
candidates
for
further
development
as
inhibitors
HMG-CoA
cyclo-oxygenase-2,
NADPH
oxidase.
In
particularly
properties.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1543 - 1543
Опубликована: Май 21, 2024
Background:
Our
objective
was
to
conduct
a
systematic
review
of
the
effects
hydrolyzed
collagen
supplementation
on
proliferation
and
activation
fibroblasts.
Methods:
The
search
conducted
for
journals
that
published
articles
in
English
language,
peer-reviewed,
meeting
following
criteria:
(a)
randomized
clinical
trials,
(b)
studies
animals
or
humans,
(c)
vitro
studies,
(d)
using
collagens
peptides,
(e)
assessing
alterations
fibroblasts
as
primary
secondary
outcome.
We
utilized
main
journal
databases
PubMed/Web
Science
ongoing
reviews
by
PROSPERO.
For
bias
risk
methodological
quality,
we
used
an
adaptation
Downs
Black
checklist.
followed
PRISMA
checklist,
from
February
2024
first
week
March
2024,
two
independent
researchers
(P.A.Q.I.
R.P.V.).
Results:
Eleven
were
included
this
review,
where
our
findings
reinforce
notion
peptides
at
concentrations
50–500
μg/mL
are
sufficient
stimulate
human
animal
tissues
without
inducing
toxicity.
Different
enzymatic
processes
may
confer
distinct
biological
properties
collagens,
allowing
scenarios
favoring
fibroblast
promotion
antioxidant
effects.
Lastly,
with
lower
molecular
weights
exhibit
greater
bioavailability
adjacent
tissues.
Conclusions:
Hydrolyzed
sizes
ranging
<3
3000
KDa
promote
stimulation
