The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(2)

Опубликована: Фев. 18, 2025

Alzheimer’s disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues mortality among older individuals. This condition involves progressive deterioration in cognitive function onset dementia. Recent advancements suggest that development AD more intricate than its underlying brain abnormalities alone. In addition, disease, metabolic syndrome, oxidative stress are all intricately linked one another. Increased concentrations circulating lipids disturbances glucose homeostasis contribute intensification lipid oxidation, leading gradual depletion body’s antioxidant defenses. heightened metabolism adversely impacts cell integrity, resulting neuronal damage. Pathways commonly acknowledged as contributors pathogenesis include alterations synaptic plasticity, disorganization neurons, death. Abnormal some membrane proteins thought creation amyloid (Aβ) oligomers, which extremely hazardous neurotransmission pathways, especially those involving acetylcholine. The interaction between Aβ oligomers these neurotransmitter systems induce cellular dysfunction, an imbalance signaling, and, ultimately, manifestation neurological symptoms. Antioxidants have impact on human since they may improve aging process by combating free radicals. Neurodegenerative diseases currently incurable; however, be effectively managed. An appealing alternative utilization natural antioxidants, such polyphenols, through diet or dietary supplements, offer numerous advantages. Within this framework, we extensively examined importance advancement well potential influence antioxidants mitigating effects.

Язык: Английский

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Multi-approach analysis reveals the mechanism by which Shugan Xiaozhi decoction protects against metabolic dysfunction-associated steatohepatitis

Phytomedicine, Год журнала: 2025, Номер 141, С. 156712 - 156712

Опубликована: Апрель 2, 2025

Metabolic dysfunction-associated steatohepatitis (MASH) is a human health-threatening hepatic disease with limited treatment strategies. As clinical Traditional Chinese Medicine compound for MASH, Shugan Xiaozhi (SGXZ) decoction has definite effect, but its mechanism in treating MASH still not very clear. Exploring the potential of SGXZ through multiomics and animal experimental validation. UPLC-ESI-MS method was used to identify main components decoction. Periodic acid-schiff (PAS), picrosirius red (PSR), oil o staining were assess effect on MCD-induced mouse model. The analyzed using techniques. TUNEL staining, western blot (WB), immunohistochemistry (IHC), kits, transmission electron microscopy (TEM), immunofluorescence (IF) validate MASH. Finally, molecular docking dynamics simulation verify targeting between key important targets intervention. Through analysis, 30 active ingredients obtained from improved as evidenced by improvement histopathology, function indexes, lipid fibrosis indicators. Both proteomic transcriptomic results suggested an role ferroptosis intervention ferroptosis-related pathways significant these analyses. In addition, reduced cell death, inflammation, oxidative stress levels restored impaired mitochondrial morphology mice. Furthermore, Mechanism experiments proved that iron metabolism peroxidation imbalance activated Xc- system does have therapeutic may be related regulation p53/ SLC7A11/GPX4 pathway reduce ferroptosis.

Язык: Английский

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Integrating bioinformatics and ferroptosis to reveal the protective mechanism of Astragaloside IV on chronic heart failure rats

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 6, 2024

Язык: Английский

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Revealing the off-flavors in hydro-distilled essential oils of sweet orange (Citrus sinensis) by flavoromics strategy and computational simulation

Food Chemistry, Год журнала: 2024, Номер 465, С. 141990 - 141990

Опубликована: Ноя. 9, 2024

Язык: Английский

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