Essential Oil of Lippia origanoides Kunth: Nanoformulation, Anticholinesterase Activity, and Molecular Docking DOI Creative Commons
Antônio Quaresma da Silva Júnior, Gabriela dos Santos Rodrigues,

Adenilson de Sousa Barroso

и другие.

Molecules, Год журнала: 2025, Номер 30(7), С. 1554 - 1554

Опубликована: Март 31, 2025

This study investigates the therapeutic potential of Lippia origanoides essential oil (LOEO) in neurological and pharmaceutical applications. The chemical composition LOEO was analyzed using gas chromatography–mass spectrometry (GC-MS), revealing major constituents, such as carvacrol, thymol, γ-gurjunene, known for their antioxidant antimicrobial properties. demonstrated significant acetylcholinesterase (AChE)-inhibitory activity, particularly a nanoformulation that enhances bioavailability stability. Additionally, constituent when tested isolation, also exhibited AChE-inhibitory activity comparable to nanoformulation. Molecular docking analysis indicated strong binding affinities between compounds AChE, supporting its neurodegenerative diseases like Alzheimer’s. silico pharmacokinetic predictions revealed favorable absorption blood–brain barrier penetration profiles key constituents. Despite promising results, this acknowledges need vivo validation long-term stability assessments Future research should focus on pharmacodynamic studies evaluating oil’s effectiveness animal models. These findings highlight valuable candidate developing natural therapies diseases.

Язык: Английский

Microfluidization Preparation of Hybrid Graphene for Enhanced Wear Resistance of Coatings DOI Open Access
He Zhang, Na Wang,

Dhandapani Kuzhandaivel

и другие.

Polymers, Год журнала: 2025, Номер 17(6), С. 824 - 824

Опубликована: Март 20, 2025

Wear resistance is the key factor that affects long-term use of leather. Graphene has excellent wear properties, but ensuring effective dispersion graphene in resin crucial for determining performance material. In this work, silica modified with polydopamine (SiO2@PDA) was used as an exfoliation agent. Using microfluidization process and water medium, silica-graphene hybrid nanoparticles (SiO2@PDA-G) were prepared from expanded graphite. These further compounded waterborne polyurethane (WPU), a superfine fiber-based fabric substrate to prepare composite coating. The results showed high shear force easily broke up lamellar structure graphite, resulting few-layer graphene. Nano-silica adsorbed on surface graphene, preventing re-aggregation between sheets. Compared WPU coating, presence SiO2@PDA-G improved mechanical properties rate average friction coefficient coating decreased by 48% 69%, respectively, tensile strength increased 83%. Therefore, study provides new strategy improving polymer materials enhancing abrasion coatings.

Язык: Английский

Процитировано

0
Essential Oil of Lippia origanoides Kunth: Nanoformulation, Anticholinesterase Activity, and Molecular Docking DOI Creative Commons
Antônio Quaresma da Silva Júnior, Gabriela dos Santos Rodrigues,

Adenilson de Sousa Barroso

и другие.

Molecules, Год журнала: 2025, Номер 30(7), С. 1554 - 1554

Опубликована: Март 31, 2025

This study investigates the therapeutic potential of Lippia origanoides essential oil (LOEO) in neurological and pharmaceutical applications. The chemical composition LOEO was analyzed using gas chromatography–mass spectrometry (GC-MS), revealing major constituents, such as carvacrol, thymol, γ-gurjunene, known for their antioxidant antimicrobial properties. demonstrated significant acetylcholinesterase (AChE)-inhibitory activity, particularly a nanoformulation that enhances bioavailability stability. Additionally, constituent when tested isolation, also exhibited AChE-inhibitory activity comparable to nanoformulation. Molecular docking analysis indicated strong binding affinities between compounds AChE, supporting its neurodegenerative diseases like Alzheimer’s. silico pharmacokinetic predictions revealed favorable absorption blood–brain barrier penetration profiles key constituents. Despite promising results, this acknowledges need vivo validation long-term stability assessments Future research should focus on pharmacodynamic studies evaluating oil’s effectiveness animal models. These findings highlight valuable candidate developing natural therapies diseases.

Язык: Английский

Процитировано

0