Antioxidant and Tyrosinase-Inhibitory Activities and Biological Bioactivities of Flavonoid Derivatives from Quercus mongolica Pollen
Molecules,
Год журнала:
2025,
Номер
30(4), С. 794 - 794
Опубликована: Фев. 8, 2025
Flavonoids,
present
in
plants
as
enriched
secondary
metabolites,
prevent
various
stresses
such
temperature
fluctuations,
acidity,
and
insect
predation,
are
commonly
found
leaves,
stems,
flowers,
serve
important
bioactive
components.
In
this
study,
a
total
of
eighteen
different
flavonoids,
including
one
newly
identified
flavonoid
glycoside,
were
successfully
isolated
from
the
pollen
Quercus
mongolica.
The
structure
novel
compound
was
determined
using
nuclear
magnetic
resonance,
mass
spectrometry,
infrared
spectroscopy.
Additionally,
GC
analysis
conducted
to
determine
sugar
moiety
new
compound,
confirming
specific
type
disaccharide
present.
18
compounds
classified
glycosides
(1-10),
flavonoids
(11-17),
isoflavone
(18).
All
evaluated
for
their
tyrosinase
inhibitory
antioxidant
activities,
structure-activity
relationships
(SARs)
also
evaluated.
Compounds
12
16
showed
higher
activities
compared
kojic
acid
positive
control.
2,
5,
8,
12,
13,
14,
demonstrated
potent
activities.
Among
these
compounds,
5
even
activity
than
ascorbic
acid.
Structure-activity
relationship
revealed
that
tyrosinase-inhibitory
enhanced
with
hydroxy
group
C-3
or
C-3't
aglycones
glycosides.
These
findings
indicate
and/or
extracts
Q.
mongolica
valuable
natural
resources
applications
pharmaceutical
cosmetic
industries.
Язык: Английский
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 265 - 265
Опубликована: Фев. 25, 2025
Bee
pollen
(BP)
is
one
of
the
richest
known
natural
resources
micronutrients
and
bioactive
phytochemicals.
Some
captivating
bioactivities
BP
compounds,
although
being
largely
investigated
for
latter
as
individual
molecules,
remain
very
scarcely
or
completely
uninvestigated
in
bee
a
whole
product.
Among
most
intriguing
these
bioactivities,
we
identified
ferroptosis
major
one.
Ferroptosis,
recently
discovered
form
cell
death
(connecting
oxidative
stress
inflammation),
complex
pathophysiological
process
crucial
perplexing
events
current
challenging
human
diseases
such
cancer,
neurodegeneration,
general
aging
diseases.
Many
compounds
were
found
to
intricately
modulate
depending
on
cellular
context
by
inducing
this
mechanism
malignant
cells
preventing
it
non-malignant
cells.
Since
research
both
fields,
i.e.,
ferroptosis,
still
recent,
deemed
necessary
undertake
review
figure
out
extent
potential
modulating
mechanisms.
Our
proved
that
wide
range
(polyphenols,
phenolamides,
carotenoids,
vitamins,
minerals,
others)
substantially
diverse
Accordingly,
phytochemicals
nutrients
showed
interesting
preclinical
studies
lead
ferroptosis-mediated
outcomes
important
processes,
including
many
aging-related
disorders.
One
paramount
challenges
be
resolved
determine
how
different
act
biological
contexts,
either
through
synergistic
antagonistic
behaviors.
We
hope
our
work
constitutes
valuable
incentive
future
investigations
promising
relevant
avenue.
Язык: Английский