Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Июнь 3, 2025
This
study
presents
an
advanced
mathematical
perspective
of
a
generalized
diabetes
model,
emphasizing
the
critical
complications
associated
with
this
disease,
such
as
cardiovascular
kidney
failure,
nerve
damage,
vision
problems,
and
weakened
immunity
conditions,
which
can
escalate
into
life-threatening
conditions
heart
attacks,
strokes,
blindness.
Blood
glucose,
essential
energy
source
for
human
body,
is
regulated
by
hormones
insulin
glucagon.
Diabetes
emerges
either
due
to
body's
resistance
or
autoimmune
destruction
insulin-producing
cells
in
pancreas.
Focusing
on
these
physiological
insights,
we
reformulate
blood
glucose-insulin
(MBGI)
model
incorporating
some
novel
parameters,
introducing
dietary
intake
compartment,
employing
new
fractional
operator
sense
fractal-fractional
derivative
better
capture
complex
dynamics
disease.
investigates
existence,
uniqueness,
Hyers-Ulam
stability
solutions
via
fixed-point
approaches,
particularly
Leray-Schauder
techniques.
Furthermore,
numerical
scheme
based
Newton's
polynomial
interpolation
developed
visualize
behavior
model.
The
attained
results
show
that
increasing
both
fractal
dimension
order
leads
crucial
reduction
glucose
concentration,
offering
valuable
insights
effective
management
control
diabetes.
Fractal and Fractional,
Год журнала:
2025,
Номер
9(2), С. 104 - 104
Опубликована: Фев. 8, 2025
This
paper
presents
a
novel
framework
for
modeling
nonlinear
fractional
evolution
control
systems.
utilizes
power
non-local
derivative
(PFD),
which
is
generalized
that
unifies
several
well-known
derivatives,
including
Caputo–Fabrizio,
Atangana–Baleanu,
and
Hattaf
as
special
cases.
It
uniquely
features
tunable
parameter
“p”,
providing
enhanced
over
the
representation
of
memory
effects
compared
to
traditional
derivatives
with
fixed
kernels.
Utilizing
fixed-point
theory,
we
rigorously
establish
existence
uniqueness
solutions
these
systems
under
appropriate
conditions.
Furthermore,
prove
Hyers–Ulam
stability
system,
demonstrating
its
robustness
against
small
perturbations.
We
complement
this
practical
numerical
scheme
based
on
Lagrange
interpolation
polynomials,
enabling
efficient
computation
solutions.
Examples
illustrating
model’s
applicability,
symmetric
cases,
are
supported
by
graphical
representations
highlight
approach’s
versatility.
These
findings
address
significant
gap
in
literature
pave
way
further
research
calculus
diverse
applications.
Fractal and Fractional,
Год журнала:
2024,
Номер
8(11), С. 638 - 638
Опубликована: Окт. 29, 2024
In
this
paper,
we
study
human
liver
disease
with
a
different
approach
of
interval-based
investigation
by
introducing
subintervals.
This
may
be
referred
to
as
short
memory
investigation.
Such
concepts
are
useful
in
problems
where
transition
is
observed
when
transitioning
from
one
subinterval
the
other
one.
We
use
classical
and
fractal-fractional-order
derivative
each
subinterval.
existence
solutions
using
Banach’s
Krasnoselskii’s
fixed-point
theorems.
Their
stability
analyzed
adopting
Hyers–Ulam
(H-U)
approach.
Also,
extended
Adams–Bashforth–Moulton
(ABM)
method,
simulate
results
that
visually
present
numerical
for
values.
Fractal and Fractional,
Год журнала:
2024,
Номер
8(12), С. 735 - 735
Опубликована: Дек. 13, 2024
Many
real-world
phenomena
exhibit
multi-step
behavior,
demanding
mathematical
models
capable
of
capturing
complex
interactions
between
distinct
processes.
While
fractional-order
have
been
successfully
applied
to
various
systems,
their
inherent
smoothness
often
limits
ability
accurately
represent
systems
with
discontinuous
changes
or
abrupt
transitions.
This
paper
introduces
a
novel
framework
for
analyzing
nonlinear
fractional
evolution
control
using
piecewise
hybrid
derivatives
respect
nondecreasing
function
W(ι).
Building
upon
the
theoretical
foundations
derivatives,
we
establish
sufficient
conditions
existence,
uniqueness,
and
Hyers–Ulam
stability
solutions,
leveraging
topological
degree
theory
functional
analysis.
Our
results
significantly
improve
existing
understanding
by
providing
less
restrictive
compared
standard
fixed-point
theorems.
Furthermore,
demonstrate
applicability
our
through
simulation
breast
cancer
disease
dynamics,
illustrating
impact
on
model’s
behavior
highlighting
advantages
over
traditional
modeling
approaches
that
fail
capture
nature
disease.
research
provides
robust
analysis
tools
exhibiting
across
diverse
fields,
including
engineering,
physics,
biology.
Fractal and Fractional,
Год журнала:
2025,
Номер
9(2), С. 105 - 105
Опубликована: Фев. 10, 2025
This
paper
investigates
a
general
class
of
variable-kernel
discrete
delay
differential
equations
(DDDEs)
with
integral
boundary
conditions
and
impulsive
effects,
analyzed
using
Caputo
piecewise
derivatives.
We
establish
results
for
the
existence
uniqueness
solutions,
as
well
their
stability.
The
at
least
one
solution
is
proven
Schaefer’s
fixed-point
theorem,
while
established
via
Banach’s
theorem.
Stability
examined
through
lens
Ulam–Hyers
(U-H)
Finally,
we
illustrate
application
our
theoretical
findings
numerical
example.
Fractal and Fractional,
Год журнала:
2025,
Номер
9(2), С. 129 - 129
Опубликована: Фев. 19, 2025
In
this
article,
we
prove
a
new
Milne-type
inequality
involving
Hadamard
fractional
integrals
for
functions
with
GA-convex
first
derivatives.
The
limits
of
the
error
estimates
involve
incomplete
gamma
and
confluent
hypergeometric
functions.
results
study
open
door
to
further
investigation
subject,
as
well
extensions
other
forms
generalized
convexity,
weighted
formulas,
higher
dimensions.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 8, 2025
The
global
prevalence
of
diabetes,
a
chronic
condition
that
disrupts
glucose
homeostasis,
is
rapidly
increasing.
Patients
with
diabetes
face
heightened
challenges
due
to
the
COVID-19
pandemic,
which
exacerbates
symptoms
associated
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection.
In
this
study,
we
developed
mathematical
model
utilizing
Mittag–Leffler
kernel
in
conjunction
generalized
fractal
fractional
operator
explore
complex
dynamics
progression
and
control.
This
effectively
captures
disease's
inherent
memory
effects
delayed
responses,
demonstrating
improved
accuracy
over
traditional
integer-order
models.
We
identified
single
equilibrium
point
represents
stable
level
healthy
individuals.
To
establish
existence
uniqueness
model,
employed
fixed
theory
alongside
Lipschitz
condition.
Ulam–Hyers
stability
proposed
was
also
examined.
Subsequently,
analyzed
chaotic
behavior
diabetic
using
feedback
control
approaches,
focusing
on
controllability
PID
techniques.
application
chaos
revealed
glucose-insulin
are
highly
sensitive
initial
conditions,
leading
oscillatory
can
result
unstable
levels.
By
implementing
fractional-order
controllers,
stabilized
dynamics,
achieving
more
reliable
blood
sugar
regulation
compared
conventional
methods,
notable
reduction
oscillation
amplitude.
conducted
numerical
simulations
validate
our
findings,
employing
Newton
polynomial
method
across
various
order
values
assess
robustness
results.
A
discussion
graphical
outcomes
from
simulations,
MATLAB
version
18,
provided,
illustrating
under
different
fractal-fractional
orders.
comprehensive
approach
enhances
understanding
underlying
mechanics
driving
dynamics.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 12, 2025
This
manuscript
illustrates
a
fractional-order
mathematical
model
for
prostate
cancer
(PC)
growth
under
pulsed
treatment,
incorporating
the
effects
of
effector
cell
killing
and
competition
between
androgen-dependent
(AD)
androgen-independent
(AI)
PC
cells.
We
establish
existence
uniqueness
solutions
using
fixed-point
theorems
(Leray-Schauder
Banach)
investigate
Ulam-Hyers
stability
to
assess
model's
solution
fractional
order.
Numerical
results
are
obtained
via
Euler
method
simulation
at
various
orders.
Graphical
illustrate
dynamics,
impact
key
parameters,
including
rate
inter-cell
competition,
is
investigated.
These
findings
provide
insights
into
complex
interplay
immune
response,
potentially
informing
therapeutic
strategies
PC.
Fractal and Fractional,
Год журнала:
2025,
Номер
9(4), С. 251 - 251
Опубликована: Апрель 15, 2025
This
paper
introduces
a
novel
fractional
Susceptible-Infected-Recovered
(SIR)
model
that
incorporates
power
Caputo
derivative
(PCFD)
and
density-dependent
recovery
rate.
enhances
the
model’s
ability
to
capture
memory
effects
represent
realistic
healthcare
system
dynamics
in
epidemic
modeling.
The
utility
flexibility
are
demonstrated
through
an
application
using
parameters
representative
of
COVID-19
pandemic.
Unlike
existing
SIR
models
often
limited
representing
diverse
adequately,
proposed
PCFD
framework
encompasses
extends
well-known
cases,
such
as
those
Caputo–Fabrizio
Atangana–Baleanu
derivatives.
We
prove
our
yields
bounded
positive
solutions,
ensuring
biological
plausibility.
A
rigorous
analysis
is
conducted
determine
local
stability,
including
derivation
basic
reproduction
number
(R0)
sensitivity
quantifying
impact
on
R0.
uniqueness
existence
solutions
guaranteed
via
recursive
sequence
approach
Banach
fixed-point
theorem.
Numerical
simulations,
facilitated
by
numerical
scheme
applied
parameter
set,
demonstrate
varying
order
significantly
alters
predicted
peak
timing
severity.
Comparisons
across
different
approaches
highlight
crucial
role
capacity
shaping
trajectories.
These
findings
underscore
potential
generalized
provide
more
nuanced
potentially
accurate
predictions
for
disease
outbreaks
like
COVID-19,
thereby
informing
effective
public
health
interventions.
Fractal and Fractional,
Год журнала:
2025,
Номер
9(4), С. 259 - 259
Опубликована: Апрель 18, 2025
In
this
research
article,
we
investigate
a
three-dimensional
dynamical
system
governed
by
fractal-fractional-order
evolution
differential
equations
subject
to
terminal
boundary
conditions.
We
derive
existence
and
uniqueness
results
using
Schaefer’s
Banach’s
fixed-point
theorems,
respectively.
Additionally,
the
Hyers–Ulam
stability
approach
is
employed
analyze
system’s
stability.
employ
vector
terminology
for
proposed
problem
make
analysis
simple.
To
illustrate
practical
relevance
of
our
findings,
apply
derived
numerical
example
graphically
solution
different
fractal-fractional
orders,
emphasizing
effect
derivative’s
order
on
behavior.