Development of Extrudable Hydrogels Based on Carboxymethyl Cellulose–Gelatin Complex Coacervates

Gels, Год журнала: 2025, Номер 11(1), С. 51 - 51

Опубликована: Янв. 8, 2025

This study investigates the 3D extrusion printing of a carboxymethyl cellulose (CMC)-gelatin complex coacervate system. Various CMC-gelatin hydrogels were prepared and analyzed to achieve this goal. The impact ratio, pH, total biopolymer concentration on coacervation formation rheological properties was evaluated characterize printability samples. Turbidity results indicated that molecular interactions between gelatin CMC biopolymers are significantly pH-dependent, occurring within range pH 3.7 5.6 for tested compositions. Confocal Laser Scanning Microscopy (CLSM) confirmed presence coacervates as spherical particles optimal range. electron microscopy micrographs supported CLSM findings, revealing greater porosity Rheological characterization demonstrated all exhibited pseudoplastic behavior, with an inverse correlation increased decreased shear viscosity. Additionally, displayed lower tackiness compared hydrogels, maximum normal force various ratios ranging from 1 15 N, notably than 29 N observed hydrogels. Mixtures 1:15 1:20 best recovery maintaining higher strength after load. system found at 6%. However, content allowed consistent extrusion. Importantly, samples successfully extruded 22 ± 2 °C, ratio yielding most printed quality. Our research highlights promise applications, particularly in areas demand precise material deposition adjustable properties.

Язык: Английский

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Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief

Gels, Год журнала: 2025, Номер 11(2), С. 131 - 131

Опубликована: Фев. 12, 2025

Local anesthetics (LAs) have been indispensable in clinical pain management, yet their limitations, such as short duration of action and systemic toxicity, necessitate improved delivery strategies. Hydrogels, with biocompatibility, tunable properties, ability to modulate drug release, extensively explored platforms for enhancing LA efficacy safety. This narrative review explores the historical development LAs, physicochemical applications, providing a foundation understanding integration hydrogels anesthetic delivery. Advances thermoresponsive, stimuli-responsive, multifunctional demonstrated significant potential prolonging analgesia reducing exposure preclinical studies, while early findings highlight feasibility thermoresponsive hydrogel formulations. Despite these advancements, challenges burst mechanical instability, regulatory considerations remain critical barriers translation. Emerging innovations, including nanocomposite hydrogels, biofunctionalized matrices, smart materials, offer solutions limitations. Future research should focus on optimizing formulations, expanding validation, integrating advanced fabrication technologies 3D printing artificial intelligence-driven design enhance personalized management. By bridging materials science pharmacology, this provides comprehensive perspective current trends future directions hydrogel-based systems.

Язык: Английский

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Development of Mn3O4 nanoparticles and Justicia adhatoda extract incorporated Carboxymethyl cellulose/Carbopol hydrogels: Rheological and in vitro bioactivity for sustained drug delivery system

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141713 - 141713

Опубликована: Март 1, 2025

Язык: Английский

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Hydrogel-Based Biointerfaces: Recent Advances, Challenges, and Future Directions in Human–Machine Integration

Gels, Год журнала: 2025, Номер 11(4), С. 232 - 232

Опубликована: Март 23, 2025

Human–machine interfacing (HMI) has emerged as a critical technology in healthcare, robotics, and wearable electronics, with hydrogels offering unique advantages multifunctional materials that seamlessly connect biological systems electronic devices. This review provides detailed examination of recent advancements hydrogel design, focusing on their properties potential applications HMI. We explore the key characteristics such biocompatibility, mechanical flexibility, responsiveness, which are essential for effective long-term integration tissues. Additionally, we highlight innovations conductive hydrogels, hybrid composite materials, fabrication techniques 3D/4D printing, allow customization to meet demands specific HMI applications. Further, discuss diverse classes polymers contribute conductivity, including conducting, natural, synthetic, polymers, emphasizing role enhancing electrical performance adaptability. In addition material examine regulatory landscape governing hydrogel-based biointerfaces applications, addressing considerations clinical translation commercialization. An analysis patent insights into emerging trends shaping future technologies human–machine interactions. The also covers range neural interfaces, soft haptic systems, where play transformative Thereafter, addresses challenges face issues related stability, scalability, while perspectives continued evolution technologies.

Язык: Английский

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Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.

Язык: Английский

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Magnetically Induced Anisotropic Microstructures on Polyethylene Glycol Hydrogel Facilitate BMSC Alignment and Osteogenic Differentiation

Gels, Год журнала: 2024, Номер 10(12), С. 814 - 814

Опубликована: Дек. 11, 2024

Many tissues exhibit structural anisotropy, which imparts orientation-specific properties and functions. However, recapitulating the cellular patterns found in anisotropic presents a remarkable challenge, particularly when using soft wet hydrogels. Herein, we develop self-assembled magnetic Fe3O4 micropatterns on polyethylene glycol hydrogels utilizing dipole–dipole interactions. Under influence of static field, nanoparticles align into highly ordered structures with height 400–600 nm width 8–10 μm. Furthermore, our layer-by-layer assembly technique enables creation oriented varying densities heights, can be further manipulated to form three-dimensional by adjusting angle field. These applied various substrates, including treated glass slides, standard silicon wafers, polydimethylsiloxane. The patterned scaffolds, modified gold coating, effectively enhance adhesion, orientation, osteogenic differentiation bone marrow-derived stem cells, is crucial for effective tissue repair. Overall, this study an efficient strategy constructing micropattern hydrogels, providing bioactive platform that significantly enhances

Язык: Английский

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From lab to life: advances in in-situ bioprinting and bioink technology

Biomedical Materials, Год журнала: 2024, Номер 20(1), С. 012004 - 012004

Опубликована: Дек. 20, 2024

Bioprinting has the potential to revolutionize tissue engineering and regenerative medicine, offering innovative solutions for complex medical challenges addressing unmet clinical needs. However, traditional

Язык: Английский

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