Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications

Discover Materials, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Язык: Английский

---

Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 215 - 215

Опубликована: Фев. 7, 2025

Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability difficulties in ensuring patient adherence. These challenges have driven the development of advanced systems (DDS), with hydrogels especially nanogels emerging as promising materials overcome these limitations. Hydrogels, their biocompatibility, high water content, stimuli-responsive properties, provide controlled targeted release. This review explores evolution, classifications versus applications delivery, detailing synthesis methods, chemical crosslinking, physical self-assembly, techniques such microfluidics 3D printing. It also examines drug-loading mechanisms (e.g., encapsulation electrostatic interactions) release strategies diffusion, stimuli-responsive, enzyme-triggered). gels demonstrate significant advantages addressing limitations traditional DDS, offering improved stability, sustained release, specificity. Their adaptability extends various routes administration, topical, oral, injectable forms, while further enhance targeting through nanoscale precision stimuli responsiveness. Although transformative potential personalized medicine, remain scalable manufacturing, regulatory approval, delivery. Future include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, optimizing surface functionalization advancements aim establish cornerstones next-generation solutions, revolutionizing paving way innovative, patient-centered treatments.

Язык: Английский

---

New Perspectives of Hydrogels in Chronic Wound Management

Molecules, Год журнала: 2025, Номер 30(3), С. 686 - 686

Опубликована: Фев. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Язык: Английский

---

Smart Hydrogels and the Promise of Multi-Responsive In-situ Systems

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер 107, С. 106758 - 106758

Опубликована: Фев. 28, 2025

Язык: Английский

---

Advances in bioinspired polymer hydrogel systems with biomedical functionalities

Science and Technology of Advanced Materials, Год журнала: 2025, Номер 26(1)

Опубликована: Март 3, 2025

The concepts of bioinspiration and biomimetics that seek to elucidate the morphology functions living organisms specific reactions within cells, extraction important elements from these design functional molecules high-performance materials are becoming more widespread. This review summarizes progress in research on hydrogels inspired by stimuli-responsiveness cell functions. For application a self-regulated release system insulin regulate blood glucose levels, various polymer have been designed using bioactive such as enzymes lectins sense concentrations. In addition, fully synthetic glucose-responsive hydrogel, complex having phenylboronic acid groups form reversible bonds with sugars multivalent hydroxyl group has researched. hydrogel can be further developed act an extracellular matrix which cells preferably reside. proliferation differentiation encapsulated controlled changes properties response sugar. Another advantage is safely retrieved adding sugar dissociate hydrogel. These bioinspired serve for development new medical technologies, molecules, regulated culture environmental matrices, applications layered three-dimensional systems create organized tissue structures.

Язык: Английский

---

Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy

Russian Chemical Reviews, Год журнала: 2024, Номер 93(11), С. RCR5150 - RCR5150

Опубликована: Окт. 30, 2024

Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.

Язык: Английский

---

Mechanics and thermodynamics of multivalent-binding induced shrinkage of hydrogels

International Journal of Mechanical Sciences, Год журнала: 2024, Номер 283, С. 109643 - 109643

Опубликована: Авг. 17, 2024

Understanding the fundamental mechanism of shrink hydrogel sensors necessitates a complete comprehension analyte-centered multivalent binding that occurs within their salt-rich microenvironments. However, mechanics and thermodynamics governing this phenomenon remain insufficiently understood. Here, we aim to derive theoretical framework examines impact temporary cross-link formation on shrinkage due specific interaction between fixed receptors analytes. As highlight our theory, mathematically quantify hydrogels' permanent cross-links using statistical describe complexation with different degrees while accounting for molecular-level transport factors when predicting sensor's shrinking characteristics. Consequently, theory unveils upper bounds set by external analyte concentration valency onto actuation sensitivity these sensors, whereby tuning receptor density permits further modulation performances. These findings tightly correlate microscopic properties macroscopic behaviors facilitating structured design regime advanced biomedical applications.

Язык: Английский

---

Colloidal Hydrogel with Staged Sequestration and Release of Molecules Undergoing Competitive Binding

ACS Nano, Год журнала: 2024, Номер 18(37), С. 25841 - 25851

Опубликована: Сен. 6, 2024

Competitive binding of distinct molecules in the hydrogel interior can facilitate dynamic exchange between and surrounding environment. The ability to control rates sequestration release these would enhance hydrogel's functionality enable targeting a specific task. Here, we report design colloidal with two pore dimensions achieve staged, diffusion-controlled scavenging dynamics undergoing competitive binding. staged strategy was shown for CpG oligodeoxynucleotide (ODN) human epidermal growth factor (hEGF), exhibiting different affinities quaternary ammonium groups hydrogel. Fast ODN from ambient environment occurred via diffusion through submicrometer-size pores, while delayed hEGF governed by its nanometer-size pores. results experiments were agreement simulation results. significance ODN-hEGF highlighted dual anti-inflammation tissue proliferation performance.

Язык: Английский

---

Recent Advances in the Drugs and Glucose-Responsive Drug Delivery Systems for the Treatment of Diabetes: A Systematic Review

Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1343 - 1343

Опубликована: Окт. 20, 2024

Diabetes is a common chronic metabolic disease. Different types of drugs play important roles in controlling diabetes and its complications, but there are some limitations. The glucose-responsive drug delivery system novel technology with potential treatment. It could automatically release response to changes glucose levels the body maintain blood within normal range. emergence glucose-sensitive provides more intelligent precise way treat diabetes. review carried out according Preferred Reporting Items for Systematic Reviews (PRISMA 2020) guidelines This focuses on recent advances different systems delivery, including oxidase, phenylboronic acid, Concanavalin A, other glucose-reactive systems. Furthermore, combined application applied hydrogels, microneedles, nanoparticles also explored summarized. new platforms sustain anti-diabetic be desirable patients. lead increased adherence glycemic outcomes detection treatment given limitations systems, solutions perspectives proposed help understanding these will helpful discovery from perspective.

Язык: Английский

---

Calcium Cross-Linked Cellulose Nanofibrils: Hydrogel Desing for Local and Controlled Nitric Oxide Release

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Nitric oxide (NO) holds promise for wound healing due to its antimicrobial properties and role in promoting vasodilation tissue regeneration. The local delivery of NO target cells or organs offers significant potential numerous biomedical applications, especially when donors are integrated into nontoxic viscous matrices. This study presents the development robust cellulose nanofibril (CNF) hydrogels designed control release nitric generated situ from a NO-donor molecule (S-nitrosoglutathione, GSNO) obtained nitrosation precursor glutathione (GSH). CNF, efficiently isolated sugar cane bagasse, exhibited high aspect ratio excellent colloidal stability water. Although depletion forces could be observed upon addition GSH, this effect did not significantly alter morphology CNF network at low GSH concentrations (<20 mM). Ionic cross-linking with Ca2+ resulted (elastic moduli ranging 300 3000 Pa) solid content. rate GSNO decreased 1.61 0.40 mmol. L–1·h–1 content raised 0.3 1.0 wt %. stabilization monitored 16 h was assigned hydrogel mesh size, which easily tailored by modifying concentration initial suspension. These results highlight CNF-based applications requiring precise delivery.

Язык: Английский

---