A
bio-based
hydrogel
is
a
complex
compound
that
consists
of
natural
biomaterials
and
widely
applied
for
various
therapeutic
purposes.
The
modification
from
traditional
to
reformulated
hydrogels
has
gained
place
at
biomedical
field
due
the
growth
benefits
such
as
drug
delivery,
tissue
engineering,
regenerative
medicine.
Moreover,
increasing
global
demand
resulted
in
worldwide
shortage
mass
formulations
raised
environmental
awareness.
By
using
instead
synthetic
ones,
these
minimize
their
negative
effects
on
environment
while
simultaneously
maximizing
successful
execution
product.
However,
mechanisms
governing
degradation
bioactivity
hydrogels,
which
dictate
release
profiles,
stability,
effectiveness,
are
not
yet
comprehensively
understood.
Therefore,
by
analyzing
recent
progress
ongoing
challenges,
this
review
will
reveal
how
advanced
quietly
transforming
future
healthcare
offering
novel
solutions
pressing
health
problems.
Abstract
Biomimetic
hydrogels
enable
biochemical,
cell
biology,
and
tissue‐like
studies
in
the
third
dimension.
Smart
are
also
frequently
used
tissue
engineering
as
drug
carriers
for
intra‐
or
extracutaneous
regenerative
medicine.
They
have
been
studied
bio‐sensor
development,
3D
culture,
organoid
growth
optimization.
Yet,
many
hydrogel
types,
adjuvant
components,
cross‐linking
methods
emerged
over
decades,
diversifying
complexifying
such
studies.
Here,
an
evaluative
overview
is
provided,
mapping
potential
applications
to
corresponding
tuning.
Strikingly,
ideal
studying
locoregional
therapy
modalities,
cold
medical
gas
plasma
technology.
These
partially
ionized
gases
produce
various
reactive
oxygen
species
(ROS)
types
along
with
other
physico‐chemical
components
ions
electric
fields,
spatio‐temporal
effects
of
these
delivered
diseased
tissues
remain
largely
elusive
date.
Hence,
this
work
outlines
promising
biomedical
research
general
science
particular
underlines
great
smart
scaffolds
current
future
therapy.
International Endodontic Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Abstract
Stimuli‐responsive
hydrogels
are
smart
and
functional
materials
that
respond
to
various
environmental
stimuli,
including
temperature,
light,
magnetic
field,
pH,
redox,
enzymes
glucose.
This
responsiveness
allows
for
the
controlled
release
of
therapeutic
agents
encapsulated
within
hydrogels,
enhancing
treatment
precision,
improving
outcomes
minimizing
side
effects.
Such
show
great
potential
in
root
canal
disinfection,
management
dental
pulp
inflammation
regeneration,
making
them
promising
candidates
more
personalized
effective
endodontic
treatments.
article
provides
an
overview
latest
advancements
design
application
stimuli‐responsive
endodontics,
emphasizing
their
revolutionize
It
also
addresses
current
challenges
explores
future
directions
aiming
inspire
motivate
researchers
further
engage
or
intensify
efforts
this
area
research.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 13, 2024
Tumor
immunotherapy,
modulating
innate
and
adaptive
immunity,
has
become
an
important
therapeutic
strategy.
However,
the
tumor
immune
microenvironment’s
(TIME)
complexity
heterogeneity
challenge
immunotherapy.
Hydrogel
is
a
hydrophilic
three-dimensional
(3D)
mesh
structure
with
good
biocompatibility
drug
release
control,
which
widely
used
in
delivery,
agriculture,
industry,
etc.
Hydrogels
loaded
cells,
cytokines,
checkpoint
inhibitors,
anti-tumor
drugs
can
achieve
targeted
delivery
ultimately
activate
response
TIME.
In
this
review,
we
will
summarize
components
of
TIME
their
effects,
emerging
immunomodulatory
agents,
characteristics
functions
hydrogels,
how
hydrogels
regulate
cells
