Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration
Dong-Wen Li,
Man Dapeng,
Yu Jiazhi
и другие.
Medical Science Monitor,
Год журнала:
2025,
Номер
31
Опубликована: Янв. 10, 2025
The
oral
cavity
is
an
open
and
complicated
structure
with
a
variety
of
factors
affecting
topical
medications.
physical
chemical
surroundings
the
can
influence
action
free
drugs.
Thus,
drug
delivery
system
serve
as
support
or
carrier.
Hydrogels
are
prospective
tissue
engineering
biomaterials
that
demonstrate
immense
potential
for
regeneration
delivery.
crosslinked
polymer
chains
3-dimensional
network
take
up
larger
volumes
liquid
have
soft,
porous
closely
resembles
living
tissue.
protect
active
from
systemic
elimination,
increase
bioavailability
absorption
into
cells,
release
modify
therapeutic
immediately
after
dosing.
In
this
review,
we
introduce
classification
hydrogels,
application
hydrogels
in
diseases
(periodontal
disease,
endodontics,
mucosal
alveolar
surgery,
cancer,
maxillofacial
bone
defects,
implantation),
summarize
synthesis
methods
applications
discuss
possible
directions
future
development
which
will
provide
new
idea
formulation
production
more
advantageous
efficient
system.
Язык: Английский
Preparation of reversible temperature sensitive acrylamide terpolymer hydrogel for cascade drug loadings
Journal of Macromolecular Science Part A,
Год журнала:
2025,
Номер
62(2), С. 187 - 199
Опубликована: Янв. 20, 2025
As
a
drug
delivery
system
with
vast
potential
applications,
hydrogels
have
garnered
significant
attention
due
to
their
unique
loading
mechanisms
and
effectiveness.
In
this
paper,
novel
reversible
thermosensitive
hydrogel
polymer,
synthesized
through
copolymerization
of
mono-6-allyl-β-cyclodextrin,
N-isopropylacrylamide,
acrylamide,
is
introduced.
This
polymer
formed
three-dimensional
network
structure
in
water,
featuring
β-cyclodextrin
hydrophobic
cavities.
The
encapsulated
molecules
could
be
slowly
progressively
released
from
both
the
IR
XRD
analysis
confirmed
successful
encapsulation
target
molecules,
sodium
salicylate
naproxen
sodium,
within
cavity
its
space.
Specifically,
when
mass
ratio
N-isopropylacrylamide/acrylamide/mono-6-allyl-β-cyclodextrin
was
9.8/0.2/0.5,
demonstrated
an
initial
gelation
temperature
34.9
°C
final
37
°C.
expansion
rate
blank
slightly
higher
than
that
drug-loaded
hydrogel.
Both
drugs
undergo
sustained
release
hydrogel,
adhering
Fick's
diffusion
law,
ensuring
consistent
8
h
maintaining
for
over
24
h,
regardless
rate.
Within
30
days,
degradation
PBS
exceeded
15%,
while
presence
lysozyme
more
40%.
These
properties
render
versatile
candidate
targeted
biomedical
offering
strategies
treating
chronic
diseases
other
conditions.
Язык: Английский
Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives
International Endodontic Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Abstract
Stimuli‐responsive
hydrogels
are
smart
and
functional
materials
that
respond
to
various
environmental
stimuli,
including
temperature,
light,
magnetic
field,
pH,
redox,
enzymes
glucose.
This
responsiveness
allows
for
the
controlled
release
of
therapeutic
agents
encapsulated
within
hydrogels,
enhancing
treatment
precision,
improving
outcomes
minimizing
side
effects.
Such
show
great
potential
in
root
canal
disinfection,
management
dental
pulp
inflammation
regeneration,
making
them
promising
candidates
more
personalized
effective
endodontic
treatments.
article
provides
an
overview
latest
advancements
design
application
stimuli‐responsive
endodontics,
emphasizing
their
revolutionize
It
also
addresses
current
challenges
explores
future
directions
aiming
inspire
motivate
researchers
further
engage
or
intensify
efforts
this
area
research.
Язык: Английский
Evaluation of a hydrogel platform for encapsulated multivalent Vibrio antigen delivery to enhance immune responses and disease protection against vibriosis in Asian seabass (Lates calcarifer)
Fish & Shellfish Immunology,
Год журнала:
2025,
Номер
160, С. 110230 - 110230
Опубликована: Фев. 25, 2025
Язык: Английский
Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Molecules: From Tissue Regeneration to Infection Control
Gels,
Год журнала:
2025,
Номер
11(3), С. 198 - 198
Опубликована: Март 12, 2025
Polysaccharide-based
hydrogels
have
emerged
as
indispensable
materials
in
tissue
engineering
and
wound
healing,
offering
a
unique
combination
of
biocompatibility,
biodegradability,
structural
versatility.
Indeed,
their
three-dimensional
polymeric
network
high
water
content
closely
resemble
the
natural
extracellular
matrix,
creating
microenvironment
for
cell
growth,
differentiation,
regeneration.
Moreover,
intrinsic
tunable
chemical
structure,
non-toxicity,
minimal
immunogenicity
make
them
optimal
candidates
prolonged
drug
delivery
systems.
Notwithstanding
numerous
advantages,
these
polysaccharide-based
are
confronted
with
setbacks
such
variability
material
qualities
depending
on
source,
susceptibility
to
microbial
contamination,
unregulated
absorption,
inadequate
mechanical
strength,
unpredictable
degradation
patterns
which
limit
efficacy
real-world
applications.
This
review
summarizes
recent
advancements
application
hydrogels,
including
cellulose,
starch,
pectin,
zein,
dextran,
pullulan
hyaluronic
acid
innovative
solutions
delivery,
engineering,
regenerative
medicine.
Future
research
should
concentrate
optimizing
hydrogel
formulations
enhance
effectiveness
medicine
antimicrobial
therapy.
Язык: Английский
Bioactive Porous Composite Implant Guides Mesenchymal Stem Cell Differentiation and Migration to Accelerate Bone Reconstruction
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12111 - 12127
Опубликована: Ноя. 1, 2024
Delayed
healing
and
non-healing
of
bone
defects
pose
significant
challenges
in
clinical
practice,
with
metal
materials
increasingly
recognized
for
their
significance
addressing
these
issues.
Among
materials,
Strontium
(Sr)
Zinc
(Zn)
have
emerged
as
promising
agents
promoting
repair.
Building
upon
this
insight,
research
evaluates
the
impact
a
porous
Sr@Zn@SiO2
nanocomposite
implant
on
regeneration,
aiming
to
advance
field
The
preparation
composite
involves
various
techniques
such
roasting,
centrifugation,
washing.
material's
composition
is
examined,
its
microstructure
element
distribution
are
analyzed
using
TEM
elemental
scanning
technology.
In
vitro
experiments
entail
isolation
characterization
BMSCs
followed
by
safety
assessments
material,
evaluation
cell
migration
capabilities,
relevant
proliferation
markers.
Mechanistically,
study
delves
into
key
targets
associated
changes
osteogenic
process.
vivo
involve
establishing
rat
femur
defect
model,
assessment
potential
Micro-CT
imaging
tissue
section
staining.
Through
investigations,
we
validate
efficacy
implant.
analyses
demonstrate
that
upregulate
BMP-2
expression,
leading
activation
Smad1/5/9
phosphorylation
subsequent
downstream
genes,
culminating
differentiation
proliferation.
And
closely
related
high
expression
CXCL12/CXCR4,
which
will
also
provide
conditions
osteogenesis.
vivo,
ability
was
confirmed
rats.
our
research,
displays
prominent
effect
promotes
promote
healing.
This
bioactive
has
surgical
application
future.
Язык: Английский