Molecules,
Год журнала:
2025,
Номер
30(3), С. 686 - 686
Опубликована: Фев. 4, 2025
Chronic
wounds
pose
a
substantial
healthcare
concern
due
to
their
prevalence
and
cost
burden.
This
paper
presents
detailed
overview
of
chronic
emphasizes
the
critical
need
for
novel
therapeutic
solutions.
The
pathophysiology
wound
healing
is
discussed,
including
stages
factors
contributing
chronicity.
focus
on
diverse
types
wounds,
such
as
diabetic
foot
necrosis,
pressure
ulcers,
venous
leg
highlighting
etiology,
consequences,
issues
they
provide.
Further,
modern
care
solutions,
particularly
hydrogels,
are
highlighted
tackling
challenges
management.
Hydrogels
characterized
multipurpose
materials
that
possess
vital
characteristics
like
capacity
retain
moisture,
biocompatibility,
incorporation
active
drugs.
Hydrogels’
effectiveness
in
applications
demonstrated
by
how
support
healing,
preserving
ideal
moisture
levels,
promoting
cellular
migration,
possessing
antibacterial
properties.
Thus,
this
hydrogel
technology’s
latest
developments,
emphasizing
drug-loaded
stimuli-responsive
underscoring
these
advanced
formulations
greatly
improve
therapy
outcomes
enabling
dynamic
focused
reactions
environment.
Future
directions
research
promote
development
customized
treatments
digital
health
tools
treatment
wounds.
Biosensors,
which
combine
physical
transducers
with
biorecognition
elements,
have
seen
significant
advancement
due
to
the
heightened
interest
in
rapid
diagnostic
technologies
across
a
number
of
fields,
including
medical
diagnostics,
environmental
monitoring,
and
food
safety.
In
particular,
polydiacetylene
(PDA)
is
gaining
attention
as
an
ideal
material
for
label-free
colorimetric
biosensor
development
its
unique
color-changing
properties
response
external
stimuli.
PDA
forms
through
self-assembly
diacetylene
monomers,
color
change
occurring
conjugated
backbone
twists
stimuli
such
temperature,
pH,
chemical
interactions.
This
enables
detection
biomarkers,
metal
ions,
toxic
compounds.
Moreover,
combination
polymeric
structures
hydrogels
further
enhances
sensitivity
structural
stability
PDA-based
biosensors,
making
them
reliable
effective
complex
biological
conditions.
review
comprehensively
examines
recent
research
trends
applications
PDA–polymeric
structure
hybrid
while
discussing
future
directions
potential
advancements
this
field.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 31, 2025
The
orderly
regulation
of
immune
inflammation
and
promotion
the
regeneration
skin
vessels
fibers
are
key
to
treatment
diabetic
injury
(DSI).
Although
various
traditional
polypeptide
biological
dressings
continue
be
developed,
their
efficacy
is
not
satisfactory.
In
recent
years,
plant-to-mammal
has
provided
an
effective
approach
for
chronic
wound
management,
but
development
plant-based
treatments
remains
challenging.
exosomes
from
Chinese
herbs
promising
healing.
this
study,
plant
derived
lemons
(Citrus
limon)
were
extracted,
was
verified.
Lemon
regulated
polarization
reprogramming
macrophages,
promoted
proliferation
migration
vascular
endothelial
cells
fibroblasts,
thus
healing
wounds.
To
solve
problems
continuous
drug
delivery
penetration
depth,
Exosomes
loaded
into
a
hydrogel
constructed
Gelatin
Methacryloyl
(GelMA)
Dialdehyde
Starch
(DAS)
that
closely
fits
skin,
absorbs
water,
swells,
moist
breathable,
effectively
promoting
sustained
slow
release
resulting
in
excellent
performance
Our
GelMA-DAS-Lemon
(GelMA/DAS/Exo
hydrogel)
patch
represents
potentially
valuable
option
repairing
wounds
clinical
applications.
Gels,
Год журнала:
2024,
Номер
10(10), С. 636 - 636
Опубликована: Сен. 30, 2024
The
innovative
fusion
of
essential
oils
with
hydrogel
engineering
offers
an
optimistic
perspective
for
the
design
and
development
next-generation
materials
incorporating
natural
bioactive
compounds.
This
review
provides
a
comprehensive
overview
latest
advances
in
use
hydrogels
containing
biomedical,
dental,
cosmetic,
food,
food
packaging,
restoration
cultural
heritage
applications.
Polymeric
sources,
methods
obtaining,
cross-linking
techniques,
functional
properties
are
discussed.
unique
characteristics
polymer
agents
highlighted.
These
include
biocompatibility,
nontoxicity,
effective
antibacterial
activity,
control
sustained
prolonged
release
active
substances,
optimal
porosity,
outstanding
cytocompatibility.
Additionally,
specific
distinctive
explored,
along
their
extraction
encapsulation
methods.
advantages
disadvantages
these
also
We
have
considered
limitations
due
to
volatility,
solubility,
environmental
factors,
stability.
importance
loading
hydrogels,
stability,
biological
activity
is
analyzed.
highlights
through
in-depth
analysis,
recent
innovations,
challenges,
future
prospects
encapsulated
potential
multiple
applications
including
biomedicine,
dentistry,
cosmetics,
conservation.
Journal of Plastic Film & Sheeting,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Plant-based
gums
and
mucilages
are
versatile
biopolymers
with
significant
industrial,
environmental,
biological
applications.
Derived
from
various
plant
sources
such
as
seeds,
roots,
leaves,
exudates,
these
polysaccharides
comprise
proteins,
bioactive
substances,
neutral
sugars
like
arabinose,
galactose,
galacturonic
acid.
Their
unique
structural
functional
properties,
high
viscosity,
water
retention,
heat
stability,
make
them
valuable
in
the
food,
pharmaceutical,
cosmetic
industries.
Due
to
their
hydrophilic
nature
ability
form
hydrogen
bonds
water,
materials
serve
emulsifiers,
film-forming
agents,
gelling
stabilizers.
Recent
studies
have
highlighted
potential
sustainable
applications,
including
biodegradable
packaging
materials,
whose
properties
crucial.
The
inclusion
of
antibacterial,
antioxidant,
immune-modulating
effects
has
expanded
use
foods
nutraceuticals.
Gums
also
play
essential
roles
pharmaceuticals
tablet
binders,
drug
carriers,
controlled-release
excipients.
Moreover,
nanotechnology
enhanced
its
applications
environmental
remediation
delivery
through
hydrogels
mucilage-coated
nanoparticles.
Despite
potential,
challenges
remain
due
variability
extraction
processing
methods.
This
analysis
underscores
transformative
plant-derived
promoting
development,
addressing
key
integrating
scientific
innovations
industrial
needs.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 296 - 296
Опубликована: Фев. 24, 2025
Melanoma,
a
highly
aggressive
form
of
skin
cancer,
poses
major
therapeutic
challenge
due
to
its
metastatic
potential,
resistance
conventional
therapies,
and
the
complexity
tumor
microenvironment
(TME).
Materials
science
nanotechnology
advances
have
led
using
nanocarriers
such
as
liposomes,
dendrimers,
polymeric
nanoparticles,
metallic
nanoparticles
transformative
solutions
for
precision
melanoma
therapy.
This
review
summarizes
findings
from
Web
Science,
PubMed,
EMBASE,
Scopus,
Google
Scholar
highlights
role
in
overcoming
treatment
barriers.
Nanoparticles
facilitate
passive
active
targeting
through
mechanisms
enhanced
permeability
retention
(EPR)
effect
functionalization
with
tumor-specific
ligands,
thereby
improving
accuracy
drug
delivery
reducing
systemic
toxicity.
Stimuli-responsive
systems
multi-stage
further
improve
overcome
challenges
poor
penetration
resistance.
Emerging
platforms
combine
diagnostic
imaging
delivery,
paving
way
personalized
medicine.
However,
there
are
still
issues
scalability,
biocompatibility,
regulatory
compliance.
comprehensive
potential
integrating
genetics
proteomics,
scalable,
patient-specific
therapies.
These
interdisciplinary
innovations
promise
redefine
provide
safer,
more
effective,
accessible
treatments.
Continued
research
is
essential
bridge
gap
between
evidence-based
scientific
clinical
applications.
Gels,
Год журнала:
2025,
Номер
11(4), С. 220 - 220
Опубликована: Март 21, 2025
The
rapid
advancement
of
wearable
electronics
has
catalyzed
the
development
flexible,
lightweight,
and
highly
conductive
materials.
Among
these,
hydrogels
have
emerged
as
promising
candidates
due
to
their
tissue-like
properties,
which
can
minimize
mechanical
mismatch
between
flexible
devices
biological
tissues
excellent
electrical
conductivity,
stretchability
biocompatibility.
However,
environmental
impact
synthetic
components
production
processes
in
conventional
poses
significant
challenges
sustainable
application.
This
review
explores
recent
advances
eco-friendly
used
healthcare,
focusing
on
design,
fabrication,
applications
green
electronics.
Emphasis
is
placed
use
natural
polymers,
bio-based
crosslinkers,
synthesis
methods
improve
sustainability
while
maintaining
high
performance.
We
discuss
incorporation
polymers
carbon-based
nanomaterials
into
environmentally
benign
matrices.
Additionally,
article
highlights
strategies
for
improving
biodegradability,
recyclability,
energy
efficiency
these
By
addressing
current
limitations
future
opportunities,
this
aims
provide
a
comprehensive
understanding
friendly
basis
next
generation
technologies.
Gels,
Год журнала:
2025,
Номер
11(4), С. 234 - 234
Опубликована: Март 23, 2025
Interest
in
developing
new,
effective
materials
for
emergency
hemostasis
and
wound
healing
is
steadily
increasing,
particularly
use
emergency,
surgical,
military
situations.
Hydrogels,
with
their
unique
retention,
swelling,
biocompatibility
properties,
have
emerged
as
essential
therapy.
This
review
provides
a
comprehensive
examination
of
recent
hydrogel
applications
acute
medical
scenarios,
including
hemostasis,
management,
drug
delivery,
soft
tissue
replacement,
engineering.
We
discuss
the
physicochemical
properties
that
make
hydrogels
suitable
rapid
response
situations,
such
tunable
mechanical
strength,
adhesiveness,
responsiveness
to
environmental
stimuli,
ability
encapsulate
release
therapeutic
agents.
Additionally,
article
explores
advancements
smart
self-healing
antimicrobial
providing
insights
into
potential
revolutionize
care
increase
survival
rates
both
civilian
applications.
Through
critical
evaluation
current
clinical
trials
practical
deployments,
this
highlights
successes
challenges
faced
integrating
protocols,
roadmap
future
research
development
dynamic
field.
