Azithromycin-Loaded Nanoparticles Incorporated in Chitosan-Based Soft Hydrogels: A Novel Approach for Dental Drug Delivery
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 304 - 304
Опубликована: Фев. 26, 2025
Background:
Azithromycin
(AZC),
a
BCS
class
II/IV
antibiotic
with
broad-spectrum
antimicrobial
activity,
has
poor
water
solubility,
limiting
its
formulation
potential.
This
study
aimed
to
develop
and
optimize
AZC-based
soft
hydrogels
for
the
first
time
improved
local
controlled
drug
release,
dental
applications.
Methods:
AZC
nanoparticles
(based
on
polyvinylpyrrolidone)
were
synthesized
via
electrospinning
enhanced
solubility
40-fold.
These
incorporated
into
chitosan
(CS)
varying
concentrations
degrees
of
deacetylation
(DDA),
optimized
using
factorial
design.
Hydrogels
characterized
mucoadhesion,
antioxidant,
anti-inflammatory,
properties,
Principal
Component
Analysis
(PCA)
assessing
correlations.
Results:
Soft
3%
CS
80%
DDA
achieved
sustained
release
(62.9–94.7%
over
48
h),
strong
biological
activity.
Higher
antioxidant
anti-inflammatory
effects
due
increased
free
amino
groups.
Antimicrobial
tests
showed
efficacy
against
Streptococcus
mutans
Staphylococcus
aureus.
PCA
revealed
an
inverse
correlation
between
mucoadhesion
positive
correlations
Conclusions:
significantly
showing
potential
delivery.
Further
clinical
validation
optimization
are
recommended.
Язык: Английский
Lyophilized and Oven-Dried Manilkara zapota Extracts: Characterization and In Vitro, In Vivo, and In Silico Analyses
Plants,
Год журнала:
2025,
Номер
14(2), С. 216 - 216
Опубликована: Янв. 14, 2025
In
this
work,
extracts
from
the
pulp,
peel,
and
seed
of
Manilkara
zapota
were
obtained
via
lyophilization
oven
drying.
Bromatological
analyses
performed
to
investigate
variabilities
in
nutritional
content
fruits
after
nine
post-harvest
days.
The
phytochemical
was
assessed
by
gas
chromatography
flame
ionization
detector
(GC-FID),
their
biological
performance
studied
using
vitro
antibacterial
antioxidant
assays
(DPPH
ABTS)
vivo
toxicity
models.
Molecular
docking
implemented
evaluate
interaction
between
polar
compounds
chicozapote
with
receptors
involved
pathogenesis
bacterial
strains.
Results
revealed
that
water
or
soluble
solids
did
not
vary
post-harvest.
It
demonstrated
oven-drying
approaches
influenced
insoluble,
total
dietary
fiber
digestible
carbohydrates
among
samples.
According
GC-FID
analysis,
it
observed
methods
also
altered
myristic
pentadecanoic
acids
extracts.
noted
activities
weak
due
MIC
(>1000
μg/mL)
IC50
(>2000
values.
Still,
poor
against
Artemia
salina
nauplii.
silico
evaluation
unveiled
M.
possess
a
high
binding
affinity
towards
DNA
gyrase
B
cultured
This
study
expands
scientific
evidence
regarding
influence
distinct
extraction
on
nutraceutical
native
importance
considering
additional
enhance
bioactivities.
Язык: Английский