Process of Fabricating Hyaluronic Acid-Based Milli-to-Microneedles Using the Bi-Directional Drawing Method DOI Creative Commons
Joon-Koo Kang,

Kihak Lee,

Y Choi

и другие.

Micro, Год журнала: 2025, Номер 5(2), С. 22 - 22

Опубликована: Май 1, 2025

Microneedles (MNs) have emerged as a promising tool for pain-free drug delivery, offering an alternative to traditional syringe-based methods. Among various types of MNs, dissolving microneedles fabricated from hyaluronic acid (HA) gained attention due their biocompatibility and ability deliver drugs with minimal discomfort. However, conventional HA MN fabrication techniques often limit needle lengths few hundred micrometers, which is insufficient deeper penetration. This study introduces novel method using bidirectional drawing lithography extend the length HA-based MNs. By adjusting viscosity solutions employing controlled pulling process, we demonstrate feasibility producing MNs ranging millimeters micrometers. An average height 15 mm tip diameters approximately 80 μm were successfully produced. advancement enhances potential transdermal delivery interstitial fluid sampling.

Язык: Английский

Polymeric Microneedles for Biomedical Applications: Innovations in Transdermal Drug Delivery and Biosensing Technologies DOI
Wendel A. Alves, Jose E. U. Rojas,

Ana C. H. Castro-Kochi

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Язык: Английский

Процитировано

0
Process of Fabricating Hyaluronic Acid-Based Milli-to-Microneedles Using the Bi-Directional Drawing Method DOI Creative Commons
Joon-Koo Kang,

Kihak Lee,

Y Choi

и другие.

Micro, Год журнала: 2025, Номер 5(2), С. 22 - 22

Опубликована: Май 1, 2025

Microneedles (MNs) have emerged as a promising tool for pain-free drug delivery, offering an alternative to traditional syringe-based methods. Among various types of MNs, dissolving microneedles fabricated from hyaluronic acid (HA) gained attention due their biocompatibility and ability deliver drugs with minimal discomfort. However, conventional HA MN fabrication techniques often limit needle lengths few hundred micrometers, which is insufficient deeper penetration. This study introduces novel method using bidirectional drawing lithography extend the length HA-based MNs. By adjusting viscosity solutions employing controlled pulling process, we demonstrate feasibility producing MNs ranging millimeters micrometers. An average height 15 mm tip diameters approximately 80 μm were successfully produced. advancement enhances potential transdermal delivery interstitial fluid sampling.

Язык: Английский

Процитировано

0