Frontiers in Sports and Active Living,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 8, 2024
In
modern
athlete
assessment,
the
integration
of
conventional
biochemical
and
ergophysiologic
monitoring
with
innovative
methods
like
telomere
analysis,
genotyping/phenotypic
profiling,
metabolomics
has
potential
to
offer
a
comprehensive
understanding
athletes'
performance
longevity.
Telomeres
provide
insights
into
cellular
functioning,
aging,
adaptation
elucidate
effects
training
on
health.
Genotype/phenotype
analysis
explores
genetic
variations
associated
athletic
performance,
injury
predisposition,
recovery
needs,
enabling
personalization
plans
interventions.
Metabolomics
especially
focusing
low-molecular
weight
metabolites,
reveal
metabolic
pathways
responses
exercise.
Biochemical
tests
assess
key
biomarkers
related
energy
metabolism,
inflammation,
recovery.
Essential
elements
depict
micronutrient
status
individual,
which
is
critical
for
optimal
performance.
Echocardiography
provides
detailed
cardiac
structure
function,
while
burnout
testing
evaluates
psychological
stress,
fatigue,
readiness
By
integrating
this
scientific
battery,
multidimensional
health
can
be
achieved,
leading
personalized
interventions
in
training,
nutrition,
supplementation,
prevention,
mental
wellness
support.
This
scientifically
rigorous
approach
hereby
presented
holds
significant
improving
longevity
through
evidence-based,
individualized
interventions,
contributing
advances
field
sports
optimization.
Advanced Exercise and Health Science,
Год журнала:
2024,
Номер
1(1), С. 3 - 15
Опубликована: Янв. 19, 2024
The
swift
acceleration
of
advances
in
precision
medicine
has
attracted
clinicians,
health
systems,
and
policymakers,
thus
leaving
an
indelible
mark
on
the
landscape
medical
practice.
increasing
acknowledgment
shows
rise
a
promising
new
field
that
can
change
practice
provide
care.
Simultaneously,
there
is
interest
exercise,
which
refers
to
approach
healthcare
fitness
where
exercise
regimens
are
tailored
individual
responses
characteristics.
Precision
evolved
as
response
understanding
individuals
exhibit
wide
range
regimens,
attributed
genetic
modifications
other
biological
factors.
purpose
this
article
offer
comprehensive
evaluation
basic
principles,
methods,
practical
applications
exercise.
Additionally,
biomarkers
serve
pivotal
indicators,
bridging
mechanisms
with
overall
health.
These
insights
into
physiological
responses,
enabling
customization
optimize
outcomes.
Herein,
underscores
transformative
potential
revolutionizing
personalized
customized
guided
by
based
biomarkers.
As
continues
evolve,
stands
at
forefront,
thereby
future
interventions
uniquely
for
optimal
Abstract
Association
between
genomic
variants
and
athletic
performance
has
seen
a
high
degree
of
controversy,
as
there
is
often
conflicting
data
far
the
association
with
endurance,
speed
strength
concerned.
Here,
findings
from
thorough
meta-analysis
4228
articles
exploring
in
power
endurance
sports
are
summarized,
aiming
to
confirm
or
overrule
genetic
all
types.
From
articles,
only
107
were
eligible
for
further
analysis,
including
37
different
genes.
these,
21
ACE
gene,
29
ACTN3
gene
8
both
genes,
54,382
subjects
total,
which
11,501
athletes
42,881
control
subjects.
These
show
that
no
statistically
significant
either
sports,
underlying
fact
it
highly
risky
even
unethical
make
such
testing
services
available
general
public.
Overall,
strict
regulatory
monitoring
should
be
exercised
by
health
other
legislative
authorities
protect
public
an
emerging
discipline
still
lacks
necessary
scientific
evidence
subsequent
approval.
Cells,
Год журнала:
2024,
Номер
13(14), С. 1212 - 1212
Опубликована: Июль 18, 2024
The
greater
muscle
fiber
cross-sectional
area
(CSA)
is
associated
with
skeletal
mass
and
strength,
whereas
atrophy
considered
a
major
feature
of
sarcopenia.
Muscle
size
polygenic
trait
influenced
by
both
environmental
genetic
factors.
However,
the
variants
underlying
inter-individual
differences
in
remain
largely
unknown.
aim
our
study
was
to
determine
whether
1535
previously
identified
genome-wide
association
appendicular
lean
are
CSA
fast-twitch
fibers
(which
better
predict
strength)
m.
vastus
lateralis
148
physically
active
individuals
(19
power-trained
28
endurance-trained
females,
age
28.0
±
1.1;
73
males,
31.1
0.8).
Fifty-seven
single-nucleotide
polymorphisms
(SNPs)
were
as
having
an
(p
<
0.05).
Of
these
57
SNPs,
31
also
handgrip
strength
UK
Biobank
cohort
(n
=
359,729).
Furthermore,
using
East
Asian
European
athletic
731)
non-athletic
515)
cohorts,
we
16
SNPs
athlete
statuses
(sprinter,
wrestler,
speed-strength
athlete)
weightlifting
performance.
All
had
same
direction
association,
i.e.,
mass-increasing
allele
positively
fibers,
performance,
power
status.
In
conclusion,
that
may,
part,
contribute
predisposition
sports.
Genes,
Год журнала:
2024,
Номер
15(9), С. 1216 - 1216
Опубликована: Сен. 18, 2024
Human
genome
research
in
sports
raises
complex
ethical
considerations
regarding
the
intersection
of
genetics
and
athletic
performance.
Pursuing
genetic
enhancements
must
uphold
fairness,
equality,
respect
for
human
dignity.
This
narrative
review
explores
dimensions
sports,
its
potential
implications
on
athletes,
integrity
sports.
As
a
review,
this
study
synthesizes
existing
literature
expert
insights
to
examine
aspects
extensively
examined
current
genetics,
performance,
concerns,
rights,
legal
regulations
within
European
context.
The
was
searched
using
SPORTDiscus,
Scopus,
Google
Scholar,
PubMed
databases.
Exploring
reveals
significant
implications,
including
discrimination,
impacts
creating
underclass
athletes.
There
are
also
definite
benefits
surrounding
testing.
In
conclusion,
contends
that
integrating
into
developing
applying
technologies
is
crucial
upholding
fundamental
principles
It
stresses
importance
open
inclusive
dialogue
about
consequences
advancements
future
generations,
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11602 - 11602
Опубликована: Окт. 29, 2024
This
narrative
review
examines
the
relationship
between
dopamine-related
genetic
polymorphisms,
personality
traits,
and
athletic
success.
Advances
in
sports
genetics
have
identified
specific
single
nucleotide
polymorphisms
(SNPs)
genes
linked
to
traits
crucial
for
performance,
such
as
motivation,
cognitive
function,
emotional
resilience.
clarifies
how
variations
can
influence
predisposition
through
dopaminergic
pathways
environmental
interactions.
Key
findings
reveal
associations
SNPs
enhanced
performance
various
sports.
For
example,
COMT
Val158Met
rs4680
BDNF
Val66Met
rs6265
are
associated
with
that
could
benefit
increased
focus,
stress
resilience
conscientiousness,
especially
martial
arts.
DRD3
rs167771
is
higher
agreeableness,
benefiting
teamwork
like
football.
synthesis
underscores
multidimensional
role
of
shaping
ability
advocates
integrating
profiling
into
personalized
training
optimize
well-being.
However,
research
gaps
remain,
including
need
standardized
protocols
exploring
gene–environment
interactions
diverse
populations.
Future
studies
should
focus
on
epigenetic
factors
inform
tailored
interventions
enhance
both
physical
psychological
aspects
performance.
By
bridging
genetics,
psychology,
exercise
science,
this
paves
way
innovative
optimization
strategies.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 17, 2025
Team
handball
performance
relies
on
physical
and
technical
abilities,
influenced
by
environmental
genetic
factors.
Variants
in
ACTN3
R577X
(rs1815739),
BDKRB2
−9/+9
(rs5810761),
AGT
Met235Thr
(rs699)
genes
are
associated
with
athletic
performance,
but
their
relevance
remains
unclear.
Therefore,
this
study
aimed
to
investigate
the
association
of
these
polymorphisms
Brazilian
junior
players.
The
included
91
male
players
(16.4
±
0.7
years)
74
age-matched
non-athletes.
Genotypes
for
(R577X),
(−9/+9),
(M235T)
were
identified
using
PCR-based
techniques.
Physical
tests
assessed
upper
limb
strength
(medicine
ball
throw)
lower
(standing
long
jump).
Genotypic
allelic
frequencies
compared
Chi-square
tests,
while
data
analyzed
ANOVA
t-tests
(p
≤
0.05).
No
significant
differences
found
genotypic
or
between
athletes
controls
polymorphisms.
Among
athletes,
RR
carriers
displayed
significantly
better
=
0.049,
d
0.48).
However,
no
genotype
anthropometric
traits.
Additionally,
associations
parameters.
This
demonstrates
that
specific
variants
(R577X)
gene
may
influence
individual
traits,
such
as
upper-body
strength,
we
limited
overall
performance.
lack
be
attributed
small
sample
size
heterogeneity
studied
population,
encouraging
further
research
larger
cohorts.
