Anxiety Stress & Coping, Год журнала: 2024, Номер unknown, С. 1 - 20
Опубликована: Авг. 21, 2024
Variation in cognitive, emotional and physical performance response to stress is attributable environmental genetic factors. Ability adapt resilience.
Язык: Английский
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2143 - 2167
Опубликована: Июнь 1, 2024
Abstract: Over the past decade, idea of targeting endocannabinoid system to treat anxiety disorders has received increasing attention. Previous studies focused more on developing cannabinoid receptor agonists or supplementing exogenous cannabinoids, which are prone various adverse effects due their strong pharmacological activity and poor selectivity, limiting application in clinical research. Endocannabinoid hydrolase inhibitors considered be most promising development strategies for treatment disorders. More recent efforts have emphasized that inhibition two major endogenous hydrolases, monoacylglycerol lipase (MAGL) fatty acid amide (FAAH), indirectly activates receptors by levels synaptic gap, circumventing desensitization resulting from direct enhancement signaling. In this review, we comprehensively summarize anxiolytic MAGL FAAH potential mechanisms, highlight reported novel natural products, provide an outlook future directions field. Keywords: inhibitors, system, disorders, anxiolytic, MAGL,
Язык: Английский
Процитировано
4
The Italian Journal of Pediatrics/Italian journal of pediatrics, Год журнала: 2025, Номер 51(1)
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 230 - 230
Опубликована: Март 27, 2025
Fibromyalgia is a chronic disease marked by extensive musculoskeletal pain, persistent fatigue, and cognitive impairments. Despite its high prevalence, the underlying pathological mechanisms of fibromyalgia are still not fully elucidated. Emerging research has identified endocannabinoid system as an essential factor in modulating pain other symptoms related to fibromyalgia. The plays key role many physiological processes such perception, mood regulation, inflammation. This review provides powerful analysis principal aspects examines evidence regarding involvement this condition, focusing on influence modulation. Moreover, dysregulation patients will be examined, with assessment how variations levels receptor activity may contribute clinical manifestations condition. A better knowledge could lead development novel strategies for managing
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3300 - 3300
Опубликована: Март 14, 2024
Traumatic muscle injuries (TMIs) and pain (MP) negatively impact athletes’ performance quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic environmental factors. Yet, existing data are scarce controversial. To provide more insights, this study aimed to investigate association single-nucleotide polymorphisms (SNPs) previously linked athletic status with TMI MP after exercise among Brazilian high-performance athletes from different sports modalities (N = 345). The important determinants was also assessed. From six evaluated SNPs (ACTN3 rs1815739, FAAH rs324420, PPARGC1A rs8192678, ADRB2 rs1042713, NOS3 rs1799983, VDR rs731236), none significantly associated TMI. Regarding exercise, ACTN3 rs1815739 (CC/CT vs. TT; adjusted odds ratio (aOR) 1.90; 95% confidence interval (95%Cl), 1.01–3.57) rs324420 (AA AC/CC; aOR 2.30; 95%Cl, 1.08–4.91) were independent predictors according multivariate binomial analyses for age (≥23 <23 years), sex (male female), tobacco consumption (yes no). External validation is warranted assess predictive value rs324420. This could implications prophylactic interventions improve
Язык: Английский
Процитировано
1
Anxiety Stress & Coping, Год журнала: 2024, Номер unknown, С. 1 - 20
Опубликована: Авг. 21, 2024
Variation in cognitive, emotional and physical performance response to stress is attributable environmental genetic factors. Ability adapt resilience.
Язык: Английский
Процитировано
0