Key candidate genes and pathways in T lymphoblastic leukemia/lymphoma identified by bioinformatics and serological analyses DOI Creative Commons
Yansong Ren, Haoyue Liang, Ya-Li Huang

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 23, 2024

T-cell acute lymphoblastic leukemia (T - ALL)/T-cell lymphoma (T-LBL) is an uncommon but highly aggressive hematological malignancy. It has high recurrence and mortality rates challenging to treat. This study conducted bioinformatics analyses, compared genetic expression profiles of healthy controls with patients having T-ALL/T-LBL, verified the results through serological indicators. Data were acquired from GSE48558 dataset Gene Expression Omnibus (GEO). T-ALL normal T cells-related differentially expressed genes (DEGs) investigated using online analysis tool GEO2R in GEO, identifying 78 upregulated 130 downregulated genes. Ontology (GO) protein-protein interaction (PPI) network analyses top 10 DEGs showed enrichment pathways linked abnormal mitotic cell cycles, chromosomal instability, dysfunction inflammatory mediators, functional defects T-cells, natural killer (NK) cells, immune checkpoints. The then validated by examining blood indices samples obtained patients, comparing T-ALL/T-LBL group control group. Significant differences observed levels various components between T-LBL patients. These include neutrophils, lymphocyte percentage, hemoglobin (HGB), total protein, globulin, erythropoietin (EPO) levels, thrombin time (TT), D-dimer (DD), C-reactive protein (CRP). Additionally, there significant peripheral leukocyte count, absolute creatinine, cholesterol, low-density lipoprotein, folate, times. associated T-LBL/T-ALL identified, HGB, EPO, TT, DD, CRP key molecular markers. will assist diagnosis applications for differential diagnosis, treatment, prognosis.

Язык: Английский

Anti-transferrin receptor antibody (JST-TFR09/PPMX-T003) induces ferroptosis in adult T-cell leukemia/lymphoma (ATLL) cells. DOI
Yanuar Rahmat Fauzi, Shingo Nakahata, Kazuya Shimoda

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 756, С. 151564 - 151564

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Key candidate genes and pathways in T lymphoblastic leukemia/lymphoma identified by bioinformatics and serological analyses DOI Creative Commons
Yansong Ren, Haoyue Liang, Ya-Li Huang

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 23, 2024

T-cell acute lymphoblastic leukemia (T - ALL)/T-cell lymphoma (T-LBL) is an uncommon but highly aggressive hematological malignancy. It has high recurrence and mortality rates challenging to treat. This study conducted bioinformatics analyses, compared genetic expression profiles of healthy controls with patients having T-ALL/T-LBL, verified the results through serological indicators. Data were acquired from GSE48558 dataset Gene Expression Omnibus (GEO). T-ALL normal T cells-related differentially expressed genes (DEGs) investigated using online analysis tool GEO2R in GEO, identifying 78 upregulated 130 downregulated genes. Ontology (GO) protein-protein interaction (PPI) network analyses top 10 DEGs showed enrichment pathways linked abnormal mitotic cell cycles, chromosomal instability, dysfunction inflammatory mediators, functional defects T-cells, natural killer (NK) cells, immune checkpoints. The then validated by examining blood indices samples obtained patients, comparing T-ALL/T-LBL group control group. Significant differences observed levels various components between T-LBL patients. These include neutrophils, lymphocyte percentage, hemoglobin (HGB), total protein, globulin, erythropoietin (EPO) levels, thrombin time (TT), D-dimer (DD), C-reactive protein (CRP). Additionally, there significant peripheral leukocyte count, absolute creatinine, cholesterol, low-density lipoprotein, folate, times. associated T-LBL/T-ALL identified, HGB, EPO, TT, DD, CRP key molecular markers. will assist diagnosis applications for differential diagnosis, treatment, prognosis.

Язык: Английский

Процитировано

1