Starting DNA Synthesis: Initiation Processes during the Replication of Chromosomal DNA in Humans DOI Open Access
Heinz‐Peter Nasheuer, Anna Marie Meaney

Опубликована: Фев. 23, 2024

The initiation reactions of DNA synthesis are central processes during human chromosomal replication. They separated into two main processes: the events at replication origins, start leading strand for each replicon, and numerous taking place lagging synthesis. In addition, a third mechanism is re-initiation after fork stalling, which takes when lesions hinder progression origin regulated multiple levels, from recognition to assembly activation replicative helicase, Cdc45-MCM2-7-GINS (CMG) complex. interactions CMG complex with eukaryotic polymerases such as polymerase α-primase (Pol α), δ ε forks play pivotal roles in including signalling unperturbed stalled forks, ‘replication stress’ events, via ATR (ATM-Rad 3-related protein kinase). All these essential accurate transfer cells’ genetic information their daughters. Failures dysfunctions gives rise genome instability followed by diseases cancer. Thus, review ‘Hallmarks Cancer: New Dimensions‘ Hanahan Weinberg (2022) called fundamental function development process cancer cells. recent years, understanding mechanisms has made substantial progress all levels will be discussed review.

Язык: Английский

Starting DNA Synthesis: Initiation Processes during the Replication of Chromosomal DNA in Humans DOI Open Access
Heinz‐Peter Nasheuer, Anna Marie Meaney

Genes, Год журнала: 2024, Номер 15(3), С. 360 - 360

Опубликована: Март 14, 2024

The initiation reactions of DNA synthesis are central processes during human chromosomal replication. They separated into two main processes: the events at replication origins, start leading strand for each replicon, and numerous taking place lagging synthesis. In addition, a third mechanism is re-initiation after fork stalling, which takes when lesions hinder progression origins regulated multiple levels, from origin recognition to assembly activation replicative helicase, Cdc45–MCM2-7–GINS (CMG) complex. interactions CMG complex with eukaryotic polymerases, polymerase α-primase, δ ε, forks play pivotal roles in These also important signalling unperturbed stalled forks, “replication stress” events, via ATR (ATM–Rad 3-related protein kinase). essential accurate transfer cells’ genetic information their daughters. Thus, failures dysfunctions these give rise genome instability causing diseases, including cancer. influential review “Hallmarks Cancer: New Dimensions”, Hanahan Weinberg (2022) therefore call fundamental function development process cancer cells. recent years, understanding mechanisms has made substantial progress all will be discussed review.

Язык: Английский

Процитировано

2
Starting DNA Synthesis: Initiation Processes during the Replication of Chromosomal DNA in Humans DOI Open Access
Heinz‐Peter Nasheuer, Anna Marie Meaney

Опубликована: Фев. 23, 2024

The initiation reactions of DNA synthesis are central processes during human chromosomal replication. They separated into two main processes: the events at replication origins, start leading strand for each replicon, and numerous taking place lagging synthesis. In addition, a third mechanism is re-initiation after fork stalling, which takes when lesions hinder progression origin regulated multiple levels, from recognition to assembly activation replicative helicase, Cdc45-MCM2-7-GINS (CMG) complex. interactions CMG complex with eukaryotic polymerases such as polymerase α-primase (Pol α), δ ε forks play pivotal roles in including signalling unperturbed stalled forks, ‘replication stress’ events, via ATR (ATM-Rad 3-related protein kinase). All these essential accurate transfer cells’ genetic information their daughters. Failures dysfunctions gives rise genome instability followed by diseases cancer. Thus, review ‘Hallmarks Cancer: New Dimensions‘ Hanahan Weinberg (2022) called fundamental function development process cancer cells. recent years, understanding mechanisms has made substantial progress all levels will be discussed review.

Язык: Английский

Процитировано

0