Two Clinically Implementable Digital PCR Assessments of DNA Methylation for Diagnosing Heavy Alcohol Consumption DOI Creative Commons
Robert A. Philibert, Steven R. H. Beach, Allan M. Andersen

и другие.

Epigenomes, Год журнала: 2024, Номер 9(1), С. 1 - 1

Опубликована: Дек. 24, 2024

Heavy alcohol consumption (HAC) has a profound adverse effect on human health. Unfortunately, there is relative lack of tools that are easily implementable in clinical settings and can be used to supplement self-reporting the diagnosis management HAC. In part, this paucity due limitations currently available biological measures mismatch between needs clinicians managing We first review pros cons existing measures. Next, we underlying theory performance characteristics two recently developed methylation-sensitive digital PCR (MSdPCR) assays, referred as Alcohol T Score (ATS) ZSCAN25, for assessment chronic recent HAC, respectively. Finally, outline paradigm improving use disorders by utilizing these new markers consumption. conclude further studies understand test each epigenetic larger, diverse populations order.

Язык: Английский

Biological aging and its association with serum neurofilament light chain levels in middle-aged African Americans: a prospective observational study DOI
Man‐Kit Lei, Mei Ling Ong, Ronald L. Simons

и другие.

Aging advances., Год журнала: 2025, Номер 2(1), С. 1 - 8

Опубликована: Фев. 6, 2025

JOURNAL/agad/04.03/02274129-202503000-00001/figure1/v/2025-03-09T135103Z/r/image-tiff This study examines the association between DNA methylation-based epigenetic aging indices and neurofilament light chain levels in middle-aged African Americans to advance understanding of neurodegeneration cognitive decline. Epigenetic was assessed samples from 2008 2019 by applying HorvathAgeAccel, HannumAgeAccel, PhenoAgeAccel, GrimAgeAccel, DunedinPACE. Controlling for financial strain, exercise, age, gender, cell-type composition, APOE-ε4 , second- third-generation aging—PhenoAgeAccel, DunedinPACE—were significantly associated with serum levels. In contrast, first-generation clocks, including HorvathAgeAccel were not related chain. These findings suggest that newer are more strongly neurodegenerative biomarkers. Integrating advanced clocks may improve early detection decline dementia, supporting personalized medicine identifying biological profiles linked risks.

Язык: Английский

Процитировано

0
Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome DOI Creative Commons
Allan M. Andersen, Steven R. H. Beach,

Willem Philibert

и другие.

Epigenetics, Год журнала: 2024, Номер 19(1)

Опубликована: Ноя. 27, 2024

The relationship of heavy alcohol consumption (HAC) and smoking to mortality in those with CHD, mechanisms through which these effects are elicited not clear. In order improve our understanding, we examined the Alcohol T-Scores (ATS), an epigenetic biomarker chronic HAC, cg05575921 methylation, a intensity, all-cause degree coronary artery obstruction cohort 217 subjects admitted for CHD-related acute syndrome (ACS). We found that 65% had ATS values indicative HAC. values, but were significantly associated (p < 0.02) subsequent proband death (total 28 deaths) Cox Proportional Hazards model showing slightly larger effect levels than age on survival (overall model, p 0.003). Subjects highest decile scores 2.4-fold increase risk as compared lowest decile. contrast, methylation 0.003) scores, inversely obstruction. Only 2 referred treatment either or drinking. conclude HAC is underappreciated driver mortality, ACS who smoke much less likely have significant upon cardiac imaging substance use may be underutilized CHD.

Язык: Английский

Процитировано

1
Two Clinically Implementable Digital PCR Assessments of DNA Methylation for Diagnosing Heavy Alcohol Consumption DOI Creative Commons
Robert A. Philibert, Steven R. H. Beach, Allan M. Andersen

и другие.

Epigenomes, Год журнала: 2024, Номер 9(1), С. 1 - 1

Опубликована: Дек. 24, 2024

Heavy alcohol consumption (HAC) has a profound adverse effect on human health. Unfortunately, there is relative lack of tools that are easily implementable in clinical settings and can be used to supplement self-reporting the diagnosis management HAC. In part, this paucity due limitations currently available biological measures mismatch between needs clinicians managing We first review pros cons existing measures. Next, we underlying theory performance characteristics two recently developed methylation-sensitive digital PCR (MSdPCR) assays, referred as Alcohol T Score (ATS) ZSCAN25, for assessment chronic recent HAC, respectively. Finally, outline paradigm improving use disorders by utilizing these new markers consumption. conclude further studies understand test each epigenetic larger, diverse populations order.

Язык: Английский

Процитировано

0