Alternative Splicing in Autism Spectrum Disorder: Recent Insights from Mechanisms to Therapy DOI Creative Commons
Michael Zheng,

Nengcheng Bao,

Zhechao Wang

и другие.

Asian Journal of Psychiatry, Год журнала: 2025, Номер unknown, С. 104501 - 104501

Опубликована: Апрель 1, 2025

Alternative splicing (AS) is a vital and highly dynamic RNA regulatory mechanism that allows single gene to generate multiple mRNA protein isoforms. Dysregulation of AS has been identified as key contributor the pathogenesis autism spectrum disorders (ASD). A comprehensive understanding aberrant mechanisms their functional consequences in ASD can help uncover molecular basis disorder facilitate development therapeutic strategies. This review focuses on major events regulators associated with ASD, highlighting roles linking defective pathogenesis. In addition, discussion how emerging technologies, such long-read sequencing, single-cell spatial transcriptomics CRISPR-Cas systems are offering novel insights into role presented. Finally, splicing-based strategies evaluated, emphasizing potential address unmet clinical needs treatment.

Язык: Английский

Alternative Splicing in Autism Spectrum Disorder: Recent Insights from Mechanisms to Therapy DOI Creative Commons
Michael Zheng,

Nengcheng Bao,

Zhechao Wang

и другие.

Asian Journal of Psychiatry, Год журнала: 2025, Номер unknown, С. 104501 - 104501

Опубликована: Апрель 1, 2025

Alternative splicing (AS) is a vital and highly dynamic RNA regulatory mechanism that allows single gene to generate multiple mRNA protein isoforms. Dysregulation of AS has been identified as key contributor the pathogenesis autism spectrum disorders (ASD). A comprehensive understanding aberrant mechanisms their functional consequences in ASD can help uncover molecular basis disorder facilitate development therapeutic strategies. This review focuses on major events regulators associated with ASD, highlighting roles linking defective pathogenesis. In addition, discussion how emerging technologies, such long-read sequencing, single-cell spatial transcriptomics CRISPR-Cas systems are offering novel insights into role presented. Finally, splicing-based strategies evaluated, emphasizing potential address unmet clinical needs treatment.

Язык: Английский

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