The Relationship Between Reduced Hand Dexterity and Brain Structure Abnormality in Older Adults DOI Creative Commons
Anna Manelis, Hang Hu, Skye Satz

и другие.

Geriatrics, Год журнала: 2024, Номер 9(6), С. 165 - 165

Опубликована: Дек. 17, 2024

Background: Hand dexterity is affected by normal aging and neuroinflammatory processes in the brain. Understanding relationship between hand brain structure neurotypical older adults may be informative about prodromal pathological processes, thus providing an opportunity for earlier diagnosis intervention to improve functional outcomes. Methods: this study investigates associations measures (≥65 years) using Nine-Hole Peg Test (9HPT) magnetic resonance imaging (MRI). Results: Elastic net regularized regression revealed that reduced dominant non-dominant hands was associated with enlarged volume of left choroid plexus, region implicated altered myelination myelin content frontal operculum, motor imagery, action production, higher-order functions. Distinct neural mechanisms underlying included differences caudate thalamic volumes as well cortical patterns frontal, temporal, parietal, occipital regions supporting sensorimotor visual processing integration, attentional control, eye movements. Although elastic identified more predictive features vs. hand, feature stability higher latter, indicating generalizability model. Conclusions: Our findings suggest 9HPT might a cost-effective screening tool early detection neurodegenerative processes. Longitudinal studies are needed validate our larger sample explore potential clinical marker.

Язык: Английский

Momentary clumsiness and attention: Everyday interactions (and risks) in the world DOI

DERRYN JEWELL,

Mark A. Schmuckler

Acta Psychologica, Год журнала: 2025, Номер 254, С. 104866 - 104866

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Improved Grip Stability in Healthcare: Mixed Reality Assistance Devices for Degenerative and Age-Related Hand Conditions DOI
Zhenhong Lei, Xinjun Li

Опубликована: Сен. 22, 2024

Язык: Английский

Процитировано

1
Neural correlates of the sound facilitation effect in the modified Simon task in older adults DOI Creative Commons
Anna Manelis, Hang Hu,

Rachel Miceli

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Авг. 14, 2023

The ability to resolve interference declines with age and is attributed neurodegeneration reduced cognitive function mental alertness in older adults. Our previous study revealed that task-irrelevant but environmentally meaningful sounds improve performance on the modified Simon task However, little known about neural correlates of this sound facilitation effect.Twenty right-handed adults [mean = 72 (SD 4), 11 female] participated fMRI study. They performed which arrows were presented either locations matching arrow direction (congruent trials) or mismatching (incongruent trials). A total 50% all trials accompanied by sounds.Participants faster concurrent sounds, independently whether congruent incongruent. effect was associated activation distributed network auditory, posterior parietal, frontal, limbic brain regions. magnitude behavioral due changes bilateral auditory cortex, cuneal occipital fusiform gyrus, precuneus, left superior parietal lobule (SPL) for No Sound vs. trials. These corresponding reaction time (RT). Older a recent history falls showed greater SPL than those without history.Our findings are consistent dedifferentiation hypothesis aging. facilitatory could be achieved through recruitment excessive resources, allows increase attention during performance. Considering critical integration multisensory information, individuals slower responses may need recruit region more actively fall overcome increased difficulty resolution. Future studies should examine relationship among SPL, sound, who at heightened risk falls.

Язык: Английский

Процитировано

3
Mixed Reality Solutions for Tremor Disorders: Ergonomic Hand Motion and AR Rehabilitation DOI Open Access
Xinjun Li, Zhenhong Lei

Опубликована: Дек. 2, 2024

This study introduces an innovative mixed reality (MR) system for managing tremor disorders, including essential and Parkinson's disease. The combines ergonomic hand motion assistance device that mimics natural movements to stabilize tremors with MR-based rehabilitation exercises dynamically adjust in difficulty. Telehealth capabilities enable remote monitoring consultations, enhancing accessibility. An iterative design process informed by feedback from medical professionals, patients, experts led significant improvements motor control, task performance, user autonomy. comprehensive MR intervention represents a substantial advancement disorder treatment, offering versatile user-friendly solution.

Язык: Английский

Процитировано

0
Editorial: Insights in neurocognitive aging and behavior: 2022 DOI Creative Commons
Kristy A. Nielson, Annalena Venneri, Shin Murakami

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Янв. 16, 2024

EDITORIAL article Front. Aging Neurosci., 16 January 2024Sec. Neurocognitive and Behavior Volume - 2024 | https://doi.org/10.3389/fnagi.2024.1361839

Язык: Английский

Процитировано

0
The relationship between brain structure and reduced hand dexterity in older adults DOI Creative Commons
Anna Manelis, Hang Hu, Skye Satz

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

ABSTRACT Hand dexterity is affected by normal aging and neuroinflammatory processes in the brain. Understanding relationship between hand brain structure neurotypical older adults may inform about prodromal pathological processes, thus providing an opportunity for earlier diagnosis intervention to improve functional outcomes. This study investigates associations measures (≥65 years) using Nine Hole Peg Test (9HPT) magnetic resonance imaging (MRI). Elastic net regularized regression revealed that reduced dominant non-dominant hands was associated with enlarged volume of left choroid plexus, region implicated altered myelination myelin content frontal operculum, motor imagery, action production, higher-order functions. Distinct neural mechanisms underlying included differences caudate thalamic volumes as well cortical patterns frontal, temporal, parietal, occipital regions supporting sensorimotor visual processing integration, attentional control, eye movements. Although elastic identified more predictive features vs. hand, feature stability higher latter, indicating generalizability model. Our findings suggest 9HPT serve a cost-effective screening tool early detection neurodegenerative processes. Longitudinal studies are needed validate our larger sample explore potential clinical marker.

Язык: Английский

Процитировано

0
The Relationship Between Reduced Hand Dexterity and Brain Structure Abnormality in Older Adults DOI Creative Commons
Anna Manelis, Hang Hu, Skye Satz

и другие.

Geriatrics, Год журнала: 2024, Номер 9(6), С. 165 - 165

Опубликована: Дек. 17, 2024

Background: Hand dexterity is affected by normal aging and neuroinflammatory processes in the brain. Understanding relationship between hand brain structure neurotypical older adults may be informative about prodromal pathological processes, thus providing an opportunity for earlier diagnosis intervention to improve functional outcomes. Methods: this study investigates associations measures (≥65 years) using Nine-Hole Peg Test (9HPT) magnetic resonance imaging (MRI). Results: Elastic net regularized regression revealed that reduced dominant non-dominant hands was associated with enlarged volume of left choroid plexus, region implicated altered myelination myelin content frontal operculum, motor imagery, action production, higher-order functions. Distinct neural mechanisms underlying included differences caudate thalamic volumes as well cortical patterns frontal, temporal, parietal, occipital regions supporting sensorimotor visual processing integration, attentional control, eye movements. Although elastic identified more predictive features vs. hand, feature stability higher latter, indicating generalizability model. Conclusions: Our findings suggest 9HPT might a cost-effective screening tool early detection neurodegenerative processes. Longitudinal studies are needed validate our larger sample explore potential clinical marker.

Язык: Английский

Процитировано

0