Quality of life in 583 head and neck cancer survivors assessed with the FACE-Q head and neck cancer module

Oral Oncology, Год журнала: 2024, Номер 153, С. 106813 - 106813

Опубликована: Апрель 30, 2024

Long-term health-related quality of life (HRQOL) is frequently affected in head and neck cancer (HNC) survivors. Due to the shortage studies investigating long-term patient-reported outcomes, we investigated HRQOL using novel FACE-Q HNC Module. A retrospective cross-sectional single-center study was performed, including all patients who underwent curative treatment for between 2006 2013. All eligible (n = 863) were invited participate whom 540 completed questionnaires. Additionally, a prospective longitudinal cohort 43 treated 2020 2022 included preoperatively filled FACE-Q, at three, six, 12 months postoperatively. domain scores analyzed visualize group characteristics by tumor site type surgical resection. Both non-surgical treatments predominantly functional domains (eating, salivation, speech, swallowing), eating distress, speaking with distinct profiles depending on treatment. In contrast, few intergroup differences observed appearance, smiling, drooling smiling distress. Longitudinal data showed significant deterioration across short-term following Patients reported long-lasting negative effects follow-up domains, whereas psychological near-complete recovery level. At long-term, various function-related psychosocial still are The results may serve better inform regard specific highlight which potentially be optimized.

Язык: Английский

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Less is more: Exploring neoadjuvant immunotherapy as a de-escalation strategy in head and neck squamous cell carcinoma treatment

Cancer Letters, Год журнала: 2024, Номер 598, С. 217095 - 217095

Опубликована: Июль 2, 2024

Язык: Английский

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De-escalated Management of HPV-positive Oropharyngeal Carcinoma: Improving Outcomes with Personalized Approaches

Seminars in Radiation Oncology, Год журнала: 2025, Номер 35(2), С. 157 - 165

Опубликована: Март 14, 2025

Язык: Английский

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Radiation-Induced Fibrosis in Head and Neck Cancer: Challenges and Future Therapeutic Strategies for Vocal Fold Treatments

Cancers, Год журнала: 2025, Номер 17(7), С. 1108 - 1108

Опубликована: Март 26, 2025

Head and neck cancer encompasses a diverse group of malignant neoplasms originating in regions such as the oral cavity, oropharynx, hypopharynx, larynx, sinonasal cavities, salivary glands. HNC represents significant public health challenge, recent reports indicate an increment incidence young adults. In 2020, approximately 377,700 new cases 177,800 HNC-related deaths were reported globally. Major risk factors include tobacco smoking, alcohol consumption, human papillomavirus (HPV) infections. impacts vital functions breathing, swallowing, speech. Treatments for this type within complex anatomy surgery, radiotherapy, chemotherapy combinations. Radiotherapy is often essential component both curative palliative treatment, balancing tumor control with preservation function appearance. However, its use can damage adjacent normal tissues, causing acute or chronic toxicity. One complication irradiation VF fibrosis, which leads to severe voice impairments, significantly affecting patients' quality life. Fibrosis involves excessive aberrant deposition extracellular matrix, driven by TGF-β1 inflammatory cytokines, ultimately impair flexibility VF. Current radiation-induced fibrosis treatments primarily focus on symptom management systemic therapies like corticosteroids, anti-inflammatory drugs, antioxidants. these have limited efficacy. Experimental approaches targeting molecular pathways involved are being explored. Given limitations treatments, advancing research crucial develop more effective therapeutic strategies that improve life patients, especially those vulnerable fibrosis.

Язык: Английский

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Pregabalin for Neuropathic Pain in Post-radiotherapy Head and Neck Cancer Patients: A Retrospective Study and Review of the Literature

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 3, 2024

Introduction: Head and neck cancer (HNC) patients may experience neuropathic pain (NP) due to radiotherapy (RT), which become chronic. Pregabalin, an anticonvulsant, alters the transmission of painful stimuli at synaptic level, modifying their perception. Pregabalin is used in NP treatment, but limited data exist on RT-treated HNC patients. This retrospective study aimed present a case series with chronic after RT managed pregabalin. Methods: patients' records from Department Oral Medicine Pathology Hospital Dentistry, School National Kapodistrian University Athens (NKUA), were searched. Outcome measures obtained using Douleur Neuropathique 4 (DN4) scale for numeric rating (NRS) pain. The use additional analgesic medication was also recorded. Results: Five (four oral one nasopharyngeal cancer) (mean age 58.5 years) who had received total dose 64.7 gray (Gy)) developed (i.e., least three months RT) NP, characterized by positive DN4 score ≥4, identified. initial assessment five six years DN4=4.6±0.89 mean NRS=6±3.08). "Burning," "pins needles," "numbness" descriptors mostly used. titrated up 150-300 mg per day; paracetamol and/or tramadol administered (daily doses 3000 100-150 mg, respectively). A substantial relief (≥50%) according Initiative Methods, Measurement, Pain Assessment Clinical Trials (IMMPACT) DN4=1.6±1.67 NRS=1.6±1.67) reported two when tapering initiated. Two (2/5) complete remission symptoms (DN4=0, NRS=0). No serious adverse effects reported; patient excess salivation. Conclusions: be promising option managing RT-related Further studies, including randomized controlled trials patients, should conducted.

Язык: Английский

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The impact of palliative radiotherapy on health-related quality of life in patients with head and neck cancer – Results of a multicenter prospective cohort study

Clinical and Translational Radiation Oncology, Год журнала: 2023, Номер 41, С. 100633 - 100633

Опубликована: Апрель 26, 2023

Palliative radiotherapy for patients with head and neck cancer can be used to alleviate symptoms. Only a few studies have investigated its impact on patient-reported outcomes (PRO). Therefore, we conducted prospective multicenter observational study. The primary objective was assess changes in health-related quality of life (HrQoL) per PRO.Eligibility criteria included i.) ii.) palliative indicated (EQD2Gy < 60 Gy). follow-up date eight weeks after (t8w). PRO measures the EORTC QLQ-C30 QLQ-H&N43 pain Numeric Rating Scale (NRS). Per protocol, five domains were reported detail as well corresponding secondary symptom determined by individual patient. We defined minimal important difference (MID) 10 points.From 06/2020 06/2022, 61 screened 21 included. Due death or decline health-status, HrQoL data available 18 at first fraction t8w. MID not met predefined terms mean values compared from Individually those t8w, 71% (5/7) improved their 40% (2/5) domain reaching respectively. There significant improvement NRS t8w Wilcoxon signed rank test (p = 0.041). Acute mucositis grade ≥3 CTCAE v5.0 occurred 44% (8/18) patients. median overall survival 11 months.Despite low patient numbers risk selection bias, our study shows some evidence benefit measured PRO.German Clinical Trial Registry identifier: DRKS00021197.

Язык: Английский

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Quality of life in head and neck cancer survivors: the Big Data for Quality of Life study

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 3, 2024

Background: The Big Data for Quality of Life (BD4QoL) study investigates quality life (QoL) in head and neck cancer (HNC) survivors, focusing on survivorship characterizing survivor demographics. Methods: We screened data from 5 studies across Europe (N=7276) included patients with a diagnosis squamous cell carcinoma (oral cavity, hypopharynx, larynx, oropharynx, nasal cavity paranasal sinuses), treated curative intent, alive after treatment, TNM 7th ed. stages I, II, III, IVa IVb, availability QoL questionnaires. Results: cohort 4448 HNC survivors primarily includes men (78%) median age 61 years. Most received radiotherapy (75%) had history smoking (78%). Survivors' scores EORTC QLQ-C30 functioning scales indicated high functioning, prevalent symptoms fatigue, pain, insomnia. Lower rates missing were observed older patients, those higher education income levels, nonsmokers, married individuals, not radiotherapy. odds ratios ranged 0.47 to 0.99, indicating these factors may predict more consistent reporting survivors. Conclusions: These support the development validation clinical prediction models multicentre randomized controlled trial.

Язык: Английский

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Revolution of Medical Review: The Application of Meta-Analysis and Convolutional Neural Network-Natural Language Processing in Classifying the Literature for Head and Neck Cancer Radiotherapy

Cancer Control, Год журнала: 2024, Номер 31

Опубликована: Янв. 1, 2024

This study explored the application of meta-analysis and convolutional neural network-natural language processing (CNN-NLP) technologies in classifying literature concerning radiotherapy for head neck cancer. It aims to enhance both efficiency accuracy reviews. By integrating statistical analysis with deep learning, this research successfully identified key studies related probability normal tissue complications (NTCP) from a vast corpus literature. demonstrates advantages these recognizing professional terminology extracting relevant information. The findings not only improve quality reviews but also offer new insights future on optimizing medical through AI technologies. Despite challenges data model generalization, work provides clear directions research.

Язык: Английский

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The role of the soft palate dose regarding normal tissue toxicities in older adults with head and neck cancer undergoing definitive radiotherapy

Radiation Oncology, Год журнала: 2024, Номер 19(1)

Опубликована: Апрель 30, 2024

The number of older adults with head and neck squamous cell carcinoma (HNSCC) is continuously increasing. Older HNSCC patients may be more vulnerable to radiotherapy-related toxicities, so that extrapolation available normal tissue complication probability (NTCP) models this population not appropriate. Hence, we aimed investigate the correlation between organ at risk (OAR) doses chronic toxicities in undergoing definitive radiotherapy.

Язык: Английский

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Qualitative Classification of Late Systemic Symptoms in Head and Neck Cancer Survivors

Cancers, Год журнала: 2024, Номер 16(11), С. 2106 - 2106

Опубликована: Май 31, 2024

Improved rates of cancer control have increased the head and neck survivor population. Cancer survivorship clinics are not widely available in USA, longitudinal supportive care for patients undergoing multimodal therapy has advanced at a pace commensurate with improvements control. Consequently, large population whose quality life may be chronically and/or permanently diminished presently exists. This lack awareness perpetuates under-recognition under-investigation, leaving survivors’ (mostly detrimental) experiences largely uncharted. We conducted qualitative exploration experiences, aiming to unpack profound impact late systemic symptoms on daily life, encompassing work, relationships, self-identity community. The study included 15 remitted survivors, ≥12 months from their final treatment, who participated semi-structured interviews by medical oncologist. Data analysis comprised thematic analysis, specifically inductive hierarchical linear modeling, enriched deductive approach anecdotal clinical reporting. Results highlighted that 43.36% all quotation material discussed pertained chronic emotion disturbance significant implications other domains life. A central symptom cluster impairments mood/emotions, activity, fatigue. Dysfunction sleep, conditions, cognitive deficits secondary cluster. Physical dysfunctionality, pain, appetite, eating, alterations experienced body temperature, constituted tertiary cluster, perhaps were surprisingly least burden among survivors. Symptoms causing heightened long-term considered epiphenomenal physical albeit being represented programs. Moving forward, development targeted multi-dimensional treatment programs encompass physical, psychosocial, spiritual needed increase specificity effective holistic solutions will foster more compassionate informed future

Язык: Английский

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