The Power of Environment: A Comprehensive Review of the Exposome’s Role in Healthy Aging, Longevity, and Preventive Medicine—Lessons from Blue Zones and Cilento

Nutrients, Год журнала: 2025, Номер 17(4), С. 722 - 722

Опубликована: Фев. 18, 2025

Aging and longevity are shaped by the exposome, a dynamic network of environmental, social, biological factors. Understanding how these exposures interact with mechanisms can inform strategies for healthier aging. Background/Objectives: This review explores exposome as system encompassing both protective risk factors, specific focus on beneficial environmental exposures, microbiome diversity, lifestyle behaviors, resilience contribute to successful By analyzing high-longevity populations, such Blue Zones Cilento, it aims identify common determinants Methods: A mixed-method study was conducted, combining systematic English literature (2003-2024) comparative analysis regions. structured search performed in PubMed, Scopus, Google Scholar using keywords "longevity", "Blue Zones", "Cilento", "microbiome", "environmental factors", related terms. Additionally, qualitative quantitative were applied assess key factors across different aging models. Results: identified contributing hotspots, including sustained exposure biodiverse natural environments, adherence Mediterranean or plant-based diet rich polyphenols probiotics, regular physical activity, strong social networks, psychological resilience. novel aspect this is role gut mediator between immune-metabolic health, influencing inflammation modulation cellular Despite geographic cultural differences, case studies reveal shared pattern that collectively enhance lifespan healthspan. Conclusions: The critical determinant trajectories, acting through complex interactions mechanisms. integrating insights from proposes comprehensive framework optimizing enhancing resilience, promoting exposures. These findings provide translational perspective guide future interventions research global health initiatives.

Язык: Английский

Lactobacilli Probiotics Prevent Amyloid-Beta Fibril Formation In Vitro

Опубликована: Апрель 23, 2025

Alzheimer's disease (AD) is characterized by the buildup of extracellular aggregated amyloid-β (Aβ) peptides, following sequential enzymatic cleavage amyloid precursor protein (APP), along with intraneuronal accumulation hyperphosphorylated Tau proteins (pTau) and subsequent neuronal loss. Despite extensive research, precise mechanisms underlying Aβ, Tau-mediated neurodegeneration remain elusive. Inhibiting aggregation has been a primary focus for mitigating toxicity. The gut-brain axis potential factor in AD progression, evidence suggesting that gut-resident bacteria may produce contribute to host aggregation. Altered gut microbial diversity also observed individuals AD. Probiotics have emerged as promising preventative measure against cognitive decline AD, several in vivo clinical trials demonstrating efficacy select bacterial strains slowing progression. However, these studies lack direct molecular on effects probiotics Aβ kinetic. In this study, we conducted bioinformatic physicochemical assessments, including docking derived from 13 probiotic Tau, identifying four predicted efficiently inhibit Kinetic confirmed both formulation its supernatant significantly inhibited conversion monomeric into forms. To explore bioavailability, administered healthy detected presence stool samples, survival through gastrointestinal tract. These findings suggest specific serve therapeutic candidates targeting aggregation, further warranted assess their utility

Язык: Английский