Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(12)
Опубликована: Авг. 27, 2024
ABSTRACT
In
recent
years,
nanotechnology
has
revolutionized
various
sectors,
particularly
in
nanomedicine,
where
nanomaterials
are
used
for
diagnosis,
monitoring,
control,
prevention,
and
treatment.
Among
these,
silver
nanoparticles
(AgNPs)
stand
out
due
to
their
remarkable
antimicrobial
cytotoxic
properties.
Traditional
chemical
synthesis
of
AgNPs
poses
significant
environmental
health
risks.
This
study
introduces
a
novel,
eco‐friendly
method
using
royal
jelly
(RJ),
nutrient‐rich
secretion
from
honeybees,
produce
with
potent
anticancer
effects.
Our
research
provides
detailed
investigation
into
RJ‐mediated
AgNPs’
modulation
the
VEGFa/PI3K/Akt/MMP‐2
pathway
HeLa
A549
cancer
cell
lines.
AgNP
characterization
was
performed
by
applying
UV–Vis
spectroscopy,
dynamic
light
scattering
(DLS),
transmission
electron
microscopy
(TEM)
combination
selected
area
diffraction
(SAED).
Cell
signaling
system
components
were
determined
ELISA
analysis.
The
cells
subjected
staining
hematoxylin
eosin
visualize
treatment’s
focuses
on
green
RJ
its
bioactivity
against
cells.
It
examines
effects
cells,
specifically
cervical
lung
Green
synthesized
demonstrate
underlying
molecular
mechanisms
contributing
activity
elucidated.
findings
revealed
decrease
arginase
upon
exposure
AgNPs,
accompanied
reductions
PI3K
phosphorylated
total
Akt
levels,
indicative
inhibition.
Additionally,
RJAgNP
demonstrated
capacity
reduce
nitric
oxide
levels
suppress
angiogenesis‐related
factors
like
VEGF
MMP‐2
inflammation‐related
TNF‐α
COX‐2,
thus
impeding
angiogenesis
metastasis.
Moreover,
our
results
shed
involvement
reactive
oxygen
intermediates
(ROIs)
mediating
apoptotic
pathways,
as
evidenced
increase
malondialdehyde
(MDA)
concentration
corresponding
ultimately
promoting
death
contributes
significantly
field
nanomedicine
therapy
introducing
use
providing
in‐depth
insights
action.
potential
RJ‐AgNPs
targeting
ROS/RNS
RSC Advances,
Год журнала:
2024,
Номер
14(26), С. 18536 - 18552
Опубликована: Янв. 1, 2024
Bacterial
infections
and
antibiotic
resistance
have
posed
a
severe
threat
to
public
health
in
recent
years.
One
emerging
promising
approach
this
issue
is
the
photocatalytic
sterilization
of
nanohybrids.
By
utilizing
ZnO
sterilization,
drawbacks
conventional
antibacterial
treatments
can
be
efficiently
addressed.
This
study
examines
enhanced
sterilizing
effectiveness
Fe-doped
nanoparticles
(Fe-ZnO
nanohybrids)
incorporated
into
polymer
membranes
that
are
active
visible
light.
Using
co-precipitation
procedure,
Fe-ZnO
nanohybrids
(Fe
Abstract
Nowadays,
extended
spectrum
β-lactamase
(ESBL)
producing
Escherichia
coli
has
been
recognized
and
recorded
worldwide
as
one
of
the
main
causing
agents
a
major
contributor
to
nosocomial
infections.
The
current
study
aimed
isolate
detect
β-lactamase-producing
E.
use
it
in
extracellular
biosynthesis
iron
oxide
nanoparticles
(Fe
2
O
3
NPs).
Fifteen
Gram-negative
(G-ve),
lactose-fermenting,
negative
citrate
non-spore-forming
coliform
bacteria
were
isolated
from
total
bacterial
isolates
water
samples.
Different
tests
performed
including
chromogenic
methods
acidimetric
iodometric
techniques
phenotypic
cloverleaf
test
Masuda
double-disc
test.
ESBL-producing
was
detected
confirmed
by
modified
double
disc
synergy
using
ceftazidime,
cefotaxime,
ceftriaxone,
amoxicillin
combined
with
clavulanic
acid,
imipenem,
cefepime,
cefoxitin.
quantitative
assay
done
micro-iodometric
assay.
Among
isolates,
S1B1
(the
highest
activity)
selected
tested
for
Fe
NPs.
produced
(NPs)
characterized
UV–visible
spectroscopy,
X-ray
diffraction
analysis,
Fourier-transform
infrared
spectroscopy
(FTIR),
transmission
electron
microscope
Zeta
analysis.
Results
successful
NPs
which
displayed
an
absorption
peak
at
346
nm
crystallographic
lattice
plane
(104).
negatively
charged
spherical-shaped
average
size
≈
24
±
nm.
FTIR
refers
presence
NPs-associated
proteins
act
stabilizing
capping
agents.
Antibacterial
activity
against
Staphylococcus
aureus
ATCC25923,
Bacillus
cereus
ATCC6633
(G+ve
bacterium),
Pseudomonas
aeruginosa
ATCC27853
(G-ve
well
strain.
revealed
moderate
strong
antibacterial
action
strains
minimum
inhibition
concentration
(MIC)
ranging
25
40
µg/ml.
The
increasing
prevalence
of
bacterial
resistance
to
conventional
antimicrobial
agents
and
nanoparticles
(NPs)
has
become
a
critical
global
health
challenge.
This
systematic
review
aimed
evaluate
strategies
for
overcoming
by
synthesizing
evidence
on
nanoparticle
composition,
functionalization,
targeted
mechanisms.
A
comprehensive
literature
search
studies
published
between
2000
2025
was
conducted,
focusing
experimental
designs
assessing
efficacy,
biofilm
disruption,
efflux
pump
inhibition.
reviewed
highlighted
advanced
formulations,
including
silver-cyanographene
conjugates,
lanthanum-functionalized
graphene
oxide,
carbon
nanogels,
which
demonstrated
enhanced
efficacy
against
resistant
strains.
Key
findings
emphasized
the
role
surface
size
modulation,
combination
therapies
in
mitigating
resistance.
Functionalized
effectively
disrupted
matrices,
inhibited
pumps,
intracellular
penetration,
reducing
survival
rates.
Despite
promising
results,
challenges
remain,
variability
limited
scalability,
long-term
ecological
impacts.
underscores
potential
innovative
combat
emphasizes
need
standardized
protocols
clinical
translation.
Polymers,
Год журнала:
2025,
Номер
17(2), С. 213 - 213
Опубликована: Янв. 16, 2025
Biomimetic
patterning
emerges
as
a
promising
antibiotic-free
approach
to
protect
medical
devices
from
bacterial
adhesion
and
biofilm
formation.
The
main
advantage
of
this
lies
in
its
simplicity
scalability
for
industrial
applications.
In
study,
we
employ
it
produce
antibacterial
coatings
based
on
silicone
materials,
widely
used
the
healthcare
industry.
doing
so,
patterned
substrates
with
topography
various
flower
petals
(rose,
chamomile,
pansy,
magnolia)
studied
relationship
between
properties
obtained
biomimetic
their
surface
topography.
To
study
surfaces,
fractal
analysis
SEM
images.
particular,
measure
complexity
heterogeneity,
values
developed
interfacial
area
ratio
(Sdr)
lacunarity
coefficient
(β).
result,
found
that
coverage
decreased
exponentially
increase
prominent
were
observed
at
β
>
1.6
Sdr
50.
results
can
be
identify
materials
superior
efficient
biomedical
Polymers,
Год журнала:
2025,
Номер
17(4), С. 506 - 506
Опубликована: Фев. 15, 2025
The
prevalence
of
bacterial
infections
in
wounds
is
a
significant
challenge
to
successful
wound
healing.
This
study
investigates
the
antibacterial
effect
hyaluronic
acid
and
alginate
aerogel
loaded
with
zinc
oxide
nanoparticles
as
potential
dressing
for
composite
was
synthesized
via
supercritical
gel
drying
characterized
by
scanning
electron
microscope,
Fourier
transform
infrared
spectroscopy,
nitrogen
porosimetry.
absorptivity
prepared
evaluated,
well
activity,
which
evaluated
against
common
pathogens,
including
Staphylococcus
aureus
Escherichia
coli,
using
agar
diffusion
method.
results
show
effective
properties
hydrogel
aerogel.
Furthermore,
water
absorption
ability
5791
1585%
unloaded
aerogels,
respectively.
ZnO
released
from
exhibited
rapid
release
followed
slow
sustained
release.
These
findings
highlight
aerogels
based
on
an
innovative
material,
expected
improve
healing
reduce
risk
infections.
