Review of Methods for Studying Viruses in the Environment and Organisms

Viruses, Год журнала: 2025, Номер 17(1), С. 86 - 86

Опубликована: Янв. 11, 2025

Recent decades have seen growing attention on viruses in the environment and their potential impacts as a result of global epidemics. Due to diversity viral species along with complexity environmental host factors, virus extraction detection methods become key for study ecology. This review systematically summarises extracting detecting pathogens from different samples (e.g., soil, water, faeces, air) biological plants, animals) existing studies, comparing similarities differences, applicability, well advantages disadvantages each method. Additionally, this discusses future directions research field. The aim is provide theoretical foundation technical reference ecology research, facilitating further exploration applications

Язык: Английский

Human Leukocyte Antigen and microRNAs as Key Orchestrators of Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8544 - 8544

Опубликована: Авг. 5, 2024

The expression of inflamma-miRs and human leukocyte antigen (HLA) haplotypes could indicate mild cognitive impairment (MCI) Alzheimer’s disease (AD). We used international databases to conduct a systematic review studies on HLA variants meta-analysis research microRNAs (miRNAs). aimed analyze the discriminative value miRNAs in MCI, AD controls evaluate protective or causative effect decline, establish role as biomarkers for early detection AD, find possible link between HLA. Statistical analysis was conducted using Comprehensive Meta-analysis software, version 2.2.050 (Biostat Inc., Englewood, NJ, USA). sizes were estimated by logarithm base 2 fold change. revealed that some variants, such HLA-B*4402, HLA-A*33:01, HLA-DPB1, HLA-DR15, HLA-DQB1*03:03, HLA-DQB1*06:01, HLA-DQB1*03:01, SNPs HLA-DRB1/DQB1, HLA-DQA1, predisposed decline before occurrence while HLA-A1*01, HLA-DRB1∗13:02, HLA-DRB1*04:04, HLA-DRB1*04:01 demonstrated role. identified let-7 miR-15/16 AD. association these two miRNA families predispose be screening prevention MCI.

Язык: Английский

Mechanisms of Low MHC I Expression and Strategies for Targeting MHC I with Small Molecules in Cancer Immunotherapy

Cancer Letters, Год журнала: 2024, Номер 611, С. 217432 - 217432

Опубликована: Дек. 25, 2024

Язык: Английский