Complications Post-COVID-19 and Risk Factors among Patients after Six Months of a SARS-CoV-2 Infection: A Population-Based Prospective Cohort Study

Epidemiologia, Год журнала: 2022, Номер 3(1), С. 49 - 67

Опубликована: Фев. 10, 2022

In October 2020, we conducted a population-based prospective cohort study to determine post-COVID-19 complications, recovery, return usual health, and associated risk factors in 536 cases of COVID-19 outbreak Borriana (Spain) by administering an epidemiological questionnaire via phone interviews. A total 484 patients participated (90.3%), age mean 37.2 ± 17.1 years, 301 females (62.2%). Mild illness was the most common manifestation. After six months, 160 (33.1%) suffered at least one complication post-COVID-19, 47 (29.4%) them sought medical assistance. The frequent persistent symptoms were hair loss, fatigue, loss smell or taste, headache. Risk with female sex (adjusted relative risk, [aRR] = 1.93 95% confidence interval [CI] 1.41–2.65), 35 years above (aRR 1.50 CI 1.14–1.99), B blood group 1.51 1.04–2.16), current smoker (RR 1.61 1.02–2.54), exposure 2.13 1.11–4.09). Male sex, younger than low exposures better recovery health. third presented compatible long-COVID-19 syndrome. conclusion, active follow-up must be implemented.

Язык: Английский

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Post-Traumatic Stress Disorder Trajectories the Year after COVID-19 Hospitalization

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(14), С. 8452 - 8452

Опубликована: Июль 11, 2022

Background: Coronavirus disease (COVID-19) hospitalization has been related to Post-Traumatic Stress Disorder (PTSD). Available information is limited by insufficient follow-up and lack of longitudinal studies. Baseline factors (e.g., sex; obesity) have PTSD, but post-hospitalization not studied. Objective: This study aimed analyse prevalence, baseline, post-discharge possible clinical courses PTSD after for COVID-19. Method: 109 patients (94.7% the original sample) completed a programme three telephone assessments during year following hospitalization. Data included sociodemographic as well psychometric tools assessing social support, perception threat life (PTL). Mixture model analysis was performed course symptoms. Chronic (>6 months) predictors were also analysed. Results: 1-year period prevalence 23.9%, peaking at six months; 11% suffered chronic PTSD. Pre- influenced onset over time. These working status, PTL, support. Interestingly, obesity, pulmonary diseases family cluster infection seem specifically Inversely, interventions, older age male gender protective. Conclusions: COVID-19 common. The analysed demographic, social, clinical, psychological predict symptomatology time can modify odds course. Clinicians could better identify cases risk Finally, treatment usual appeared outcome should be proposed with

Язык: Английский

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The Hospitalized COVID-19 Subjects and Post-traumatic Stress Disorder

Опубликована: Янв. 1, 2025

Язык: Английский

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Mental Health of COVID-19 Survivors at 6 and 12 Months Postdiagnosis: A Cohort Study

Frontiers in Psychiatry, Год журнала: 2022, Номер 13

Опубликована: Апрель 8, 2022

Objective As COVID-19 persists around the world, it is necessary to explore long-term mental health effects in survivors. In this study, we investigated outcomes of survivors at 6 and 12 months postdiagnosis. Methods Posttraumatic stress disorder (PTSD checklist for DSM-5, PCL-5), depression (PHQ-9), anxiety (Generalized Anxiety Disorder Scale, GAD-7), resilience (Connor-Davidson Resilience CD-RISC-10), perceived social support (PSSS), personality traits (Chinese Big Five Personality Inventory-15, CBF-PI-15), sociodemographic information were examined among 511 (48.1%, females; M age = 56.23 years first assessment) The data analyzed with Wilcoxon signed rank tests multivariable logistic regression models. Results prevalence anxiety, depression, posttraumatic (PTSD) after diagnosis was 13.31% 6.26%; 20.35% 11.94%; 13.11% 6.07%, respectively. risk factors all symptoms as follows: higher neuroticism; lower openness, extraversion, agreeableness, resilience; greater life disruptions due COVID-19; poorer living standards; increased PTSD or Conclusion improved between Mental workers should pay attention group, especially factors.

Язык: Английский

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The Moderating Effect of Resilience on Mental Health Deterioration among COVID-19 Survivors in a Mexican Sample

Healthcare, Год журнала: 2022, Номер 10(2), С. 305 - 305

Опубликована: Фев. 5, 2022

Resilience has been reported to be a protective psychological variable of mental health; however, little is known about its role in COVID-19 survivors. Thus, this study, we aimed evaluate the levels depression, anxiety, stress, traumatic impact, and resilience associated with COVID-19, as well investigate moderating variable. A sample 253 participants responded an online survey; all were previously diagnosed by nasopharyngeal swab RT-PCR test, older than 18 years, signed informed consent form. Significant negative correlations found between health variables. Higher was significantly related lower impact event, depression when number symptoms low. Only duration short medium or high distress reduced. Moreover, moderated effects on health, even if relapse occurred. The results emphasize need for interdisciplinary interventions at providing patients social resources cope disease, probable relapses.

Язык: Английский

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Metabolic Profile of Patients with Long COVID: A Cross-Sectional Study

Nutrients, Год журнала: 2023, Номер 15(5), С. 1197 - 1197

Опубликована: Фев. 27, 2023

A significant proportion of patients experience a wide range symptoms following acute coronavirus disease 2019 (COVID-19). Laboratory analyses long COVID have demonstrated imbalances in metabolic parameters, suggesting that it is one the many outcomes induced by COVID. Therefore, this study aimed to illustrate clinical and laboratory markers related course with Participants were selected using care programme for Amazon region. Clinical sociodemographic data glycaemic, lipid, inflammatory screening collected, cross-sectionally analysed between COVID-19 outcome groups. Of 215 participants, most female not elderly, 78 hospitalised during phase. The main reported fatigue, dyspnoea, muscle weakness. Our findings show abnormal profiles (such as high body mass index measurement triglyceride, glycated haemoglobin A1c, ferritin levels) are more prevalent worse presentations previous hospitalisation long-term symptoms). This prevalence may suggest propensity present abnormalities involved cardiometabolic health.

Язык: Английский

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Corrigendum to “The prevalence and long-term health effects of long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis”

EClinicalMedicine, Год журнала: 2023, Номер 59, С. 101959 - 101959

Опубликована: Апрель 19, 2023

[This corrects the article DOI: 10.1016/j.eclinm.2022.101762.].

Язык: Английский

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Dysregulated TP53 Among PTSD Patients Leads to Downregulation of miRNA let-7a and Promotes an Inflammatory Th17 Phenotype

Frontiers in Immunology, Год журнала: 2022, Номер 12

Опубликована: Янв. 4, 2022

Post-traumatic stress disorder (PTSD) is a psychiatric and patients diagnosed with PTSD often express other comorbid health issues, particularly autoimmune inflammatory disorders. Our previous reports investigating peripheral blood mononuclear cells (PBMCs) from showed that these exhibit an increased T helper (Th) cell phenotype widespread downregulation of microRNAs (miRNAs), key molecules involved in post-transcriptional gene regulation. A combination analyzing prior datasets on miRNA expression PBMCs Control samples, as well experiments using primary collected human Controls blood, was used to evaluate TP53 expression, DNA methylation, modulation Th17 development. In the current report, we note several downregulated miRNAs were linked tumor protein 53 (TP53), also known p53. Expression data revealed compared Controls, exhibited decreased which correlated phenotype. Decreased population shown be associated increase methylation promotor region. Lastly, most significantly TP53-associated miRNA, let-7a, negatively regulate cells. Let-7a activated CD4+ influence development function, via alterations IL-6 IL-17 production, respectively. Collectively, studies reveal could susceptible inflammation by epigenetic dysregulation TP53, alters profile favor proinflammatory

Язык: Английский

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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

Neural Regeneration Research, Год журнала: 2024, Номер 20(7), С. 1957 - 1970

Опубликована: Июль 29, 2024

Post-traumatic stress disorder is a mental caused by exposure to severe traumatic life events. Currently, there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic disorder. In addition, the heterogeneity of clinical presentations overlap symptoms other conditions lead misdiagnosis inappropriate treatment. Evidence suggests this condition multisystem affects many biological systems, raising possibility peripheral markers disease may be used diagnose We performed PubMed search for microRNAs (miRNAs) in (PTSD) could serve as diagnostic found 18 original research articles on studies human patients published January 2012 December 2023. These included four whole blood, seven blood mononuclear cells, plasma extracellular vesicles/exosomes, one serum exosomes. One these had also plasma. Two were excluded they did not involve microRNA biomarkers. Most collected samples from adult male Veterans who returned deployment been exposed combat, only two recently traumatized subjects. measuring miRNA expression levels, microarray analysis, Seq NanoString panels. Only six real time polymerase chain reaction assay determine/validate PTSD subjects compared controls. The miRNAs found/validated considered potential candidate include miR-3130-5p blood; miR-193a-5p, -7113-5p, -125a, -181c, -671-5p cells; miR-10b-5p, -203a-3p, -4488, -502-3p, -874-3p, -5100, -7641 vesicles/exosomes; miR-18a-3p -7-1-5p Several important limitations identified need taken into account future studies. Further warranted war veterans children, adolescents, adults having use animal models subjected various stressors effects suppressing overexpressing specific microRNAs.

Язык: Английский

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Psychological Distress among Hospitalized COVID-19 Patients in Denmark during the First 12 Months of the Pandemic

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(16), С. 10097 - 10097

Опубликована: Авг. 15, 2022

This study aimed to investigate psychological distress among patients hospitalized with a COVID-19 diagnosis in Denmark during the first 12 months of pandemic and assess changes three following discharge. A single-center prospective observational survey between May 2020 2021 was conducted. Participants completed at time points: admission, 1 3 after Psychological assessed by validated scales measuring symptoms related depression, anxiety, stress, insomnia, post-traumatic stress disorder (PTSD), health-related quality life (HRQoL). In total, 95 were included. At proportion depression 43%, anxiety 32%, moderate/high level 39%, insomnia 52%, probable/positive PTSD 19%. The burden decreased significantly over time, while there no significant change or PTSD. Suboptimal levels physical mental HRQoL detected admission but improved time. Patients due year experienced considerable some improvements within

Язык: Английский

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