Dietary macro and micronutrients associated with MASLD: Analysis of a national US cohort database

Annals of Hepatology, Год журнала: 2024, Номер 29(3), С. 101491 - 101491

Опубликована: Фев. 25, 2024

Our objective was to measure and compare the intake of macro micronutrients in a cohort individuals with Metabolic Syndrome Associated Steatotic Liver Disease (MASLD) compared matched controls identify areas further research this area; we identified nutrition-associated associations MASLD United States general population.

Язык: Английский

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Fruit and vegetable intake and the risk of non-alcoholic fatty liver disease: a meta-analysis of observational studies

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 21, 2024

This systematic review and meta-analysis of clinical observational studies aims to clarify the correlation between intake levels fruits vegetables non-alcoholic fatty liver disease (NAFLD).

Язык: Английский

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Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update

Medicina, Год журнала: 2025, Номер 61(1), С. 83 - 83

Опубликована: Янв. 7, 2025

Metabolic syndrome is a metabolic disorder characterized by hypertension, dyslipidemia, impaired glucose tolerance, and abdominal obesity. Impaired insulin action or resistance initiates syndrome. The prevalence of increasing all over the world. Insulin results in defective metabolism carbohydrates lipids, addition to low-grade chronic inflammation. associated with syndrome, which risk factor for number pathological conditions, such as Type 2 diabetes (T2D), cardiovascular disease (CVD), nonalcoholic fatty liver (NAFLD), polycystic ovarian (PCOS). Genome-wide association studies have increased our understanding many loci linked these diseases others. In this review, we discuss its contribution diseases. We also genetic them. Genetic testing invaluable identification stratification susceptible populations and/or individuals. After individuals been identified via screening, lifestyle modifications regular exercise, weight loss, healthy diet, smoking cessation can reduce prevent pathologies.

Язык: Английский

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The Global, Regional, and National Burden and Trends of NAFLD in 204 Countries and Territories: An Analysis From Global Burden of Disease 2019

JMIR Public Health and Surveillance, Год журнала: 2022, Номер 8(12), С. e34809 - e34809

Опубликована: Окт. 25, 2022

Nonalcoholic fatty liver disease (NAFLD) poses a substantial socioeconomic burden and is becoming the fastest growing driver of chronic disease, potentially accompanied by poor prognosis.We aim to elucidate global regional epidemiologic changes in NAFLD during past 30 years explore interconnected diseases.Data on incidence, prevalence, death, disability-adjusted life-years (DALYs) were extracted from Global Burden Disease Study 2019. The age-standardized incident rate (ASIR), prevalent (ASPR), death (ASDR), DALYs calculated eliminate confounding effects age when comparing between different geographical regions. In addition, we also investigated correlation sociodemographic index (SDI). Finally, associations 3 common comorbidities with determined.Globally, incidence prevalence both increased drastically decades (incidence: 88,180 1990 172,330 2019, prevalence: 561,370,000 1,235,700,000 2019), mainly affecting young adults who aged 15 49 years. ASIR slightly 1.94 per 100,000 population 2.08 while ASPR 12,070 15,020 number deaths attributable significantly as well 93,760 168,970 2019 2,711,270 4,417,280 respectively. However, ASDR presented decreasing trends values estimated annual percentage change equaling -0.67 -0.82, respectively (ASDR: 2.39 2.09 2019; DALYs: 63.28 53.33 2019). Thereinto, dominated patients are older than 50 Moreover, SDI appeared have obvious negative ASPR, ASDR, among 21 regions 204 countries, although there no marked association ASIR. found that positively related those diabetes mellitus type 2, stroke, ischemic heart disease.NAFLD leading increasingly serious health challenges worldwide. morbidity clear shift toward populations, heavier was observed populations relatively low SDI. Comprehensive acquisition pattern for identification high-risk may help policy makers clinical physicians develop cost-effective prevention control strategies, especially countries high burden.

Язык: Английский

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Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(20), С. 13495 - 13495

Опубликована: Окт. 18, 2022

Nonalcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic injury; however, mechanisms underlying its progression have not been fully elucidated. Pathophysiological studies stated that NAFLD is significantly influenced by dietary and environmental factors could participate in development through different mechanisms. Currently, “plastic pollution” one most challenging problems worldwide since several plastics potential toxic or endocrine disputing properties. Specifically, intake microplastics (MPs) nanoplastics (NPs) water diet and/or inhalation from suspended particles well established, these found human samples. Laboratory animals exposed to MPs develop inflammation, immunological responses, disruptions, alterations lipid energy metabolism, among other disorders. additives also demonstrated adverse reactions. There evidence their are “obesogens” pathogenesis modifying gut microbiota composition even worsen fibrosis. Although exposure seems clear, relationship with requires further study, prevention be a possible personalized therapeutic strategy. Adequate mitigation strategies worldwide, reducing pollution levels MPs, reduce risk NAFLD.

Язык: Английский

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