Gut microbiome and clinical and lifestyle host factors associated with recurrent positive RT-PCR for SARS-CoV-2

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Дек. 18, 2024

Background SARS-CoV-2 and COVID-19 are still active in the population. Some patients remained PCR-positive for more than 4 weeks, called “persistently PCR-positive”. Recent evidence suggests a link between gut microbiota susceptibility to COVID-19, although no studies have explored persistent PCR conditions. We aimed evaluate relationship positive RT-PCR, microbiome, individual host determinants. Methods A shotgun metagenomic analysis was conducted on fecal samples from 28 individuals affected by COVID-19. Patients were divided into two groups: those who had cleared virus within 30 days (designated as control group) (n = 15), beyond (called PCR+ 13). also investigated correlation prolonged viral clearance several additional factors, including clinical parameters, immune responses, microbial metabolites, dietary habits. Results The composition functionality of microbiome varied based duration positivity determined PCR. Compared group, group exhibited elevated pathogen levels augmented diversity functional gene families (p-value < 0.05). multi-omics integrating metagenomics, metadata revealed specific contribution certain blood markers this basophils, IgM, IgG (both general SARS-CoV-2), liver damage. Unhealthy diet identified significant factor influencing positivity. Conclusions These findings indicate that may play role delayed RT-PCR results. Our study contributes understanding factors mediators linking disease outcomes. Further large-scale must confirm these data; however, they suggest relevance monitoring changes early post-viral years providing healthcare support.

Язык: Английский

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Potential reduction of post-acute sequelae of SARS-CoV-2 symptoms via vaccination

Journal of Investigative Medicine, Год журнала: 2023, Номер 71(8), С. 889 - 895

Опубликована: Июль 27, 2023

The objective of this observational study is to determine whether vaccination for SARS-CoV-2 alters the clinical presentation post-COVID conditions (PCC). Self-reported data provided by patients requesting care PCC at Mayo Clinic were analyzed assess a relationship between status prior COVID infection and symptoms. In all, 477 subjects included in study. total, 245 (51.4%) vaccinated. Vaccinated with reported less abdominal pain, anosmia, parosmia, chest pain/tightness, dizziness, numbness/tingling, dyspnea, spells/tremors, weakness. For hospitalized who developed PCC, vaccinated cough, dyspnea. After applying Bonferroni correction multiple comparisons, decreased pain remained significant. We conclude that against may reduce symptoms leading improved morbidity function. Further studies on impact recovery are needed.

Язык: Английский

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The Pathogenesis of Gastrointestinal, Hepatic, and Pancreatic Injury in Acute and Long Coronavirus Disease 2019 Infection

Gastroenterology Clinics of North America, Год журнала: 2022, Номер 52(1), С. 1 - 11

Опубликована: Дек. 5, 2022

Язык: Английский

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INTERSEÇÃO VIRAL: ANÁLISE DOS EFEITOS NEUROLÓGICOS PÓS-COVID NO SISTEMA NERVOSO

Опубликована: Март 5, 2024

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OS EFEITOS DA CL EM OUTROS SISTEMAS CORPORAIS

Опубликована: Март 5, 2024

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