Aerosol in the oral health-care setting: a misty topic

Clinical Oral Investigations, Год журнала: 2023, Номер 27(S1), С. 23 - 32

Опубликована: Май 10, 2023

Abstract Studies have shown that mouth and respiratory tract microorganisms can be transported in aerosol spatter. Due to aerosol-generating procedures, there are potentially various infection risks for patients those working health care, especially oral care. Dental contaminate not only the mucous membranes of health-care professional’s mouth, passages, eyes but also exposed surfaces materials environment. As such, preventing disease transmission within offices is important issue. Since start COVID-19 pandemic, an innumerable amount (mis)information advice on how stay safe prevent spread coronavirus has been published. What preventive measures taken counteract this, what we learned during pandemic? This review summarizes relevant literature addressed presence dispersal spatter as a concern It includes sources dental aerosol, their potential threats, strategies controlling mitigating impact. shows further research needed better understand develop effective them. Clinical relevance Using personal protective equipment, high-volume evacuation systems pre-procedural antimicrobial agents help reduce settings protect well-being workers patients.

Язык: Английский

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Supporting the Aspecific Physiological Defenses of Upper Airways against Emerging SARS-CoV-2 Variants

Pathogens, Год журнала: 2023, Номер 12(2), С. 211 - 211

Опубликована: Янв. 29, 2023

The rapid rollout of COVID-19 vaccines in 2021 sparked general optimism toward controlling the severe form disease, preventing hospitalizations and COVID-19-associated mortality, transmissibility SARS-CoV-2 infection [...]

Язык: Английский

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Improving Nasal Protection for Preventing SARS-CoV-2 Infection

Biomedicines, Год журнала: 2022, Номер 10(11), С. 2966 - 2966

Опубликована: Ноя. 17, 2022

Airborne pathogens, including SARS-CoV-2, are mainly contracted within the airway pathways, especially in nasal epithelia, where inhaled air is mostly filtered resting conditions. Mucosal immunity developing after SARS-CoV-2 infection or vaccination this part of body represents one most efficient deterrents for preventing viral infection. Nonetheless, complete lack such protection naïve seronegative subjects, limited capacity neutralizing new and highly mutated lineages, along with progressive waning mucosal over time, lead way to considering alternative strategies constructing walls that could stop entrap virus at mucosa surface, which area primarily colonized by Omicron sublineages. Among various preventive strategies, those based on generating physical barriers nose, aimed impeding host cell penetration (i.e., using compounds mucoadhesive properties, act hindering, entrapping adsorbing virus), association its cellular receptors administering anti-SARS-CoV-2 antibodies agents inhibit priming binding spike protein) be considered appealing perspectives. Provided these proven safe, comfortable, compatible daily life, we suggest prioritizing their usage subjects enhanced risk contagion, during high-risk activities, as well patients more likely develop severe forms

Язык: Английский

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Administration of Clinical COVID-19 Mouthwashing Protocol and Potential Modulation of Pediatric Oral Bacterial Prevalence of Selenomonas noxia: A Pilot Study

Pediatric Reports, Год журнала: 2023, Номер 15(3), С. 414 - 425

Опубликована: Июль 11, 2023

Dental office protocols to combat the SARS-CoV-2 (COVID-19) pandemic include mouth washing for an extended 60 s, thereby reducing detectable oral virus. However, it is unclear whether this protocol has any effects on newly identified periodontal pathogen and obesity-related bacterium often found among pediatric patients, Selenomonas noxia. To determine if mouthwash measurable effect S. noxia amongst clinical saliva samples were obtained from patients during routine visits care treatment. Using approved protocol, two collected same visit before after chlorhexidine (Sample A, Sample B). The third sample C) was taken at recall appointment-usually between eight weeks later. A total of n = 97 pre-mouthwash samples, equal number matching post-mouthwash (n 97) collected, with a small 36) that subsequently identified. demographic composition study analyzed using Chi square statistics. DNA pre-, post-, collections B, isolated screened qPCR validated primers, which revealed 11.1% 4/36) tested positive 0% 0/36) B testing 13.9% 5/36) positive. In addition, comparative analysis cycle threshold data relatively lower expression (quantity) as determined by two-tailed t-tests (p=0.004). These results provide new evidence prevalence while also demonstrating COVID-19 prior treatment periods extending up s may be sufficient reduce levels noxia-at least temporarily. More research will needed these limited short- or exhibit more lasting in long-term.

Язык: Английский

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Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis

BMC Infectious Diseases, Год журнала: 2023, Номер 23(1)

Опубликована: Окт. 11, 2023

Abstract Background COVID-19 has been a public health emergency of international concern (PHEIC) for lengthy period time. The novel coronavirus is primarily spread via aerosols at short distance, with infected individuals releasing large amounts when speaking and coughing. However, there an open question regarding whether mouthwash could effectively reduce virus transmission during the pandemic support prevention infection among medical workers. Methods Cochrane Library, PubMed, Web Science, Embase databases were systematically searched from inception each database to January 12, 2023 currently available randomized clinical trials (RCTs) on effect load in oral cavity patients. treatment group received rinsing mouth, while control placebo or distilled water primary outcomes CT value viral load. Odds ratios (ORs) estimated using random-effects model. Subgroup sensitivity analyses performed minimize bias impact heterogeneity. Results Thirteen RCTs included. Seven studies reported intervention coronavirus. analysis results showed that had positive [ SMD = 0.35, 95% CI (0.21, 0.50)] compared group. In addition, subgroup significant values group, chlorhexidine (CHX) [SMD 0.33, (0.10, 0.56)], povidone-iodine (PVP-I) 0.61, (0.23, 0.99)], hydrogen peroxide (HP) 1.04, (0.30, 1.78)] as ingredient mouthwash. Six load, 263 cases 164 was no statistical difference between -0.06, (-0.18, 0.05)]. by measurement time, statistically differences groups 0.52, (0.31, 0.72)] − 0.32, (− 0.56, 0.07)] within 30 min gargling. Conclusions summary, some efficacy reducing coronavirus, especially after mouth. Mouthwash containing CHX, PVP-I HP all effects values, PVP-I-containing may be promising option infections relieve virus-related symptoms. dose frequency use are still lacking, which limit application Trial registration Protocol registration: protocol registered PROSPERO (CRD42023401961).

Язык: Английский

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Efficacy of povidone-iodine nasal rinse and mouth wash in COVID-19 management: a prospective, randomized pilot clinical trial (povidone-iodine in COVID-19 management)

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Март 1, 2024

Abstract Objectives/Hypothesis To assess the efficacy of 0.23% povidone-iodine (PVP-I) nasal rinses and mouth washes on detectability coronavirus disease 2019 (COVID-19) virus cycle threshold (Ct) values in nasopharyngeal swabs. Study design This was an open-label, prospective, randomized, placebo-controlled clinical trial. Setting The study conducted King Saud University Medical City, Riyadh, Saudi Arabia, from August 2021 to July 2022. Methods Participants diagnosed with SARS-CoV-2 were randomly assigned one three groups, participants receiving either PVP-I, 0.9% normal saline (NS) washes, or no intervention (control group). Nasopharyngeal swabs taken 4, 8, 12, 18 days after first swab measure Ct. Results A total 19 involved this study. mean viral survival 9.8, 12.6 for NS, control respectively, a statistically significant difference ( p = 0.046). Ct 23 ± 3.4, 23.5 6.3, 26.3 5.9 at time recruitment 25.2 3.5, 15 11.7, 26.9 6.4 4 respectively. Conclusions When used continuously concentration 0.23%, PVP-I showed promising results terms decreasing pandemic burden by reducing period infectiousness load. However, use did not result significantly different changes quality-of-life parameters recently vaccinated mild COVID-19 patients.

Язык: Английский

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Why not to pick your nose: Association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers

PLoS ONE, Год журнала: 2023, Номер 18(8), С. e0288352 - e0288352

Опубликована: Авг. 2, 2023

Hospital health care workers (HCW) are at increased risk of contracting SARS-CoV-2. We investigated whether certain behavioral and physical features, e.g. nose picking wearing glasses, associated with infection risk.To assess the association between related or features (nail biting, having a beard) incidence SARS-CoV-2-infection.In cohort study among 404 HCW in two university medical centers Netherlands, SARS-CoV-2-specific antibodies were prospectively measured during first phase pandemic. For this received an additional retrospective survey regarding (e.g. picking) features.In total 219 completed (response rate 52%), 34/219 (15.5%) became SARS-CoV-2 seropositive follow-up from March 2020 till October 2020. The majority (185/219, 84.5%) reported their least incidentally, frequency varying monthly, weekly daily. was higher compared to participants who refrained (32/185: 17.3% vs. 2/34: 5.9%, OR 3.80, 95% CI 1.05 24.52), adjusted for exposure COVID-19. No observed nail beard, infection.Nose is infection. therefore recommend facilities create more awareness, by educational sessions implementing recommendations against prevention guidelines.

Язык: Английский

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Aerosols in Dentistry

Опубликована: Янв. 1, 2024

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Efficacy of Povidone-Iodine Nasal Rinse and Mouth Wash in COVID-19 Management: A Prospective, Randomized Pilot Clinical Trial (Povidone-Iodine in COVID-19 Management)

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 6, 2023

Abstract Objectives/Hypothesis: To assess the efficacy of 0.23% povidone-iodine (PVP-I) nasal rinses and mouth washes on detectability coronavirus disease 2019 (COVID-19) virus cycle threshold (Ct) values in nasopharyngeal swabs. Study Design: This was an open-label, prospective, randomized, placebo-controlled clinical trial. Setting: The study conducted King Saud University Medical City, Riyadh, Saudi Arabia, from August 2021 to July 2022. Methods: Participants diagnosed with SARS-CoV-2 were randomly assigned one three groups, participants receiving either PVP-I, 0.9% normal saline (NS) washes, or no intervention (control group). Nasopharyngeal swabs taken 4, 8, 12, 18 days after first swab measure Ct. Results: A total 19 involved this study. mean viral survival 9.8, 12.6 for NS, control respectively, a statistically significant difference (p = 0.046). Ct 23 ± 3.4, 23.5 6.3, 26.3 5.9 at time recruitment 25.2 3.5, 15 11.7, 26.9 6.4 4 respectively. Conclusions: When used continuously concentration 0.23%, PVP-I showed promising results terms decreasing pandemic burden by reducing period infectiousness load. However, use did not result significantly different changes quality-of-life parameters recently vaccinated mild COVID-19 patients.

Язык: Английский

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