The Role of the Adrenal–Gut–Brain Axis on Comorbid Depressive Disorder Development in Diabetes

Biomolecules, Год журнала: 2023, Номер 13(10), С. 1504 - 1504

Опубликована: Окт. 10, 2023

Diabetic patients are more affected by depression than non-diabetics, and this is related to greater treatment resistance associated with poorer outcomes. This increase in the prevalence of diabetics also hyperglycemia hypercortisolism. In diabetics, hyperactivity HPA axis occurs parallel gut dysbiosis, weakness intestinal permeability barrier, high bacterial-product translocation into bloodstream. Diabetes induces an blood–brain barrier (BBB) Toll-like receptor 4 (TLR4) expression hippocampus. Furthermore, lipopolysaccharide (LPS)-induced behaviors neuroinflammation exacerbated diabetic mice. context, we propose here that hypercortisolism, association leads exacerbation hippocampal neuroinflammation, glutamatergic transmission, neuronal apoptosis, leading development aggravation mood disorder patients.

Язык: Английский

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Effect of 12-week endurance training on biochemical parameters in elite football players: A comprehensive analysis

JOURNAL SPORT AREA, Год журнала: 2023, Номер 8(3), С. 388 - 395

Опубликована: Окт. 19, 2023

Endurance training plays a pivotal role in football performance, shaping players’ cardiovascular fitness and metabolic adjustments. The purpose of this study is to investigate the different changes biochemical parameters after exposure 12 weeks circuit based on endurance football. A total fifteen elite players, with an average age 16.87 ± 1.13 years, weight 61.87 5.94 kg, height 172.82 5.18 cm, participated study. On average, they had been for 5.0 1.0 years intermediate experience national-level competitions 4.0 years. Following initial data collection, participants engaged twelve-week programme, involving one hour daily four days week. Pre-experimental designs were used collection process. Further, analysis extraction data, descriptive statistics t-tests employed. significance level was set at P < 0.05. Significant found from baseline post-treatment each player’s parameters. significant increase HDL, haemoglobin, creatine, RBC decrease LDL VLDL observed. findings underscore potential benefits as reflected positive alterations various However, more comprehensive conclusions deeper understanding broader implications. Future research recommended larger sample sizes, control groups, detailed performance outcome measurements. This contributes our knowledge physiological responses players advantages, it offers optimising their overall health.

Язык: Английский

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Probing the oral-brain connection: Oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 31, 2024

The role of the oral microbiome in mental health has recently been appreciated within proposed oral-brain axis. This study examined structure and composition salivary a large-scale population-based cohort individuals reporting symptoms (n = 306) compared to mentally healthy controls 164) using 16S rRNA sequencing. Mental were evaluated validated questionnaires included depression, anxiety, posttraumatic stress disorder, with accompanying periodontal outcomes. Participants also indicated current or previous diagnoses periodontitis, gingivitis. variables influenced overall microbiome. PTSD correlated reduced Haemophilus sputorum elevated Prevotella histicola levels. Anxiety disorder diagnosis was associated decreased Neisseria elongate increased Oribacterium asaccharolyticum. P. abundance positively depressive scores negatively psychological quality life. A higher Shuttleworthia lower Capnocytophaga evident those who reported clinical periodontitis diagnosis. Functional prediction analysis revealed potential for tryptophan metabolism/degradation axis, which confirmed by plasma serotonin levels across symptomatic groups. Higher Eggerthia parainfluenzae psychotherapeutic efficacy. sheds light on intricate interplay between microbiota, outcomes, health, emphasizing need further exploration axis pave way novel therapeutic interventions predicting response.

Язык: Английский

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Central neurophysiological mechanisms of stress resistance in post-traumatic stress disorder

Журнал высшей нервной деятельности им И П Павлова, Год журнала: 2024, Номер 74(5), С. 565 - 590

Опубликована: Ноя. 27, 2024

Язык: Английский

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Stress Response of Neurotransmitters and Micro-RNAs 34c and 7a in Serum and Hypothalamus of Rats after Exposure to Different Powers of Noise

Journal of the Medical Research Institute /Journal of Medical Research Institute, Год журнала: 2023, Номер 44(2), С. 42 - 50

Опубликована: Дек. 31, 2023

Noise pollution is considered a stressful biological factor which can be hazardous for the health.Noise stress stimulates hypothalamus-pituitaryadrenal axis (HPA).Acute and chronic increase such hormones as epinephrine, norepinephrine cortisol.The purpose of this research to determine neurotransmitter levels.(dopamine (DA), (NE), serotonin (5-HT)) microRNA-7a -34c in serum hypothalamus tissue rats exposed different powers noise.To achieve aim, 40 adult albino male were grouped 4 groups (10 each).Group I (GI) represented control group test (GII, GIII GIV) noise at 85 dB, 100 dB 135 respectively hours/day from 7a.m -11a.m. 15 days.The results indicated that exposure led significant level NE tested also relative expression microRNA-34c (GIV) lead activation (fight-flight) response.Also reduction levels DA 5-HT (GIII) 135dB.Noise potent stressor caused decrease neurotransmitters may disorders function HPA release hormones.

Язык: Английский

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