The Effects of Curcumin on Neurodegenerative Diseases: a Systematic Review

Journal of Herbal Medicine, Год журнала: 2023, Номер 42, С. 100771 - 100771

Опубликована: Сен. 20, 2023

Язык: Английский

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Identification and verification of genes associated with hypoxia microenvironment in Alzheimer’s disease

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 27, 2023

As the incidence of Alzheimer's disease (AD) increases year by year, more people begin to study this disease. In recent years, many studies on reactive oxygen species (ROS), neuroinflammation, autophagy, and other fields have confirmed that hypoxia is closely related AD. However, no researchers used bioinformatics methods relationship between AD hypoxia. Therefore, our aimed screen role hypoxia-related genes in clarify their diagnostic significance. A total 7681 differentially expressed (DEGs) were identified GSE33000 differential expression analysis cluster analysis. Weighted gene co-expression network (WGCNA) was detect 9 modules 205 hub with high correlation coefficients. Next, machine learning algorithms applied four key selected. Through verification external dataset quantitative real-time PCR (qRT-PCR), model established ANTXR2, BDNF NFKBIA. The results suggest may increase risk in-depth are still needed investigate association, article would guide insights directions for further research.

Язык: Английский

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Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder

Biomolecules, Год журнала: 2023, Номер 13(9), С. 1396 - 1396

Опубликована: Сен. 15, 2023

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. CDD characterized broad spectrum of clinical manifestations, including early-onset refractory epileptic seizures, intellectual disability, hypotonia, visual disturbances, and autism-like features. The Cdkl5 knockout (KO) mouse recapitulates several features CDD, autistic-like behavior, impaired learning memory, motor stereotypies. These behavioral alterations are accompanied diminished neuronal maturation survival, reduced dendritic branching spine maturation, marked microglia activation. There currently no cure or effective treatment to ameliorate symptoms disease. Aerobic exercise known exert multiple beneficial effects brain, not only increasing neurogenesis, but also improving cognitive tasks. To date, studies have analyzed effect physical on phenotype model. In view positive voluntary running brain models various human disorders, we sought determine whether daily running, sustained over month, could improve development defects KO mice. Our study showed that long-term improved hyperlocomotion impulsivity behaviors memory performance This correlated with increased hippocampal inhibition structural improvements were associated BDNF levels. Given function, present findings support benefits as an adjuvant therapy for CDD.

Язык: Английский

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Effects of acute moderate-intensity exercise on executive function in children with preterm birth: A randomized crossover study

Early Human Development, Год журнала: 2023, Номер 183, С. 105795 - 105795

Опубликована: Май 30, 2023

Язык: Английский

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Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder

Опубликована: Июль 20, 2023

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. CDD characterized broad spectrum of clinical manifestations, including early-onset refractory epileptic seizures, intellectual disability, hypotonia, visual disturbances, and autism-like features. The Cdkl5 knockout (KO) mouse recapitulates several features CDD, autistic-like behavior, impaired learning memory, motor stereotypies. These behavioral alterations are accompanied diminished neuronal maturation survival, reduced dendritic branching spine maturation, marked microglia activation. There currently no cure or effective treatment to ameliorate symptoms disease. Aerobic exercise known exert multiple beneficial effects brain, not only increasing neurogenesis, but also improving cognitive tasks. To date, studies have analyzed effect physical on phenotype model. In view positive voluntary running brain models various human disorders, we sought determine whether daily running, sustained over month, could improve development defects KO mice. Our study showed that long-term improved hyperlocomotion impulsivity behaviors, memory performance This correlated with increased hippocampal inhibition structural improvements were associated BDNF levels. Given function, present findings support benefits as an adjuvant therapy for CDD.

Язык: Английский

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Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder

Опубликована: Сен. 7, 2023

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. CDD characterized broad spectrum of clinical manifestations, including early-onset refractory epileptic seizures, intellectual disability, hypotonia, visual disturbances, and autism-like features. The Cdkl5 knockout (KO) mouse recapitulates several features CDD, autistic-like behavior, impaired learning memory, motor stereotypies. These behavioral alterations are accompanied diminished neuronal maturation survival, reduced dendritic branching spine maturation, marked microglia activation. There currently no cure or effective treatment to ameliorate symptoms disease. Aerobic exercise known exert multiple beneficial effects brain, not only increasing neurogenesis, but also improving cognitive tasks. To date, studies have analyzed effect physical on phenotype model. In view positive voluntary running brain models various human disorders, we sought determine whether daily running, sustained over month, could improve development defects KO mice. Our study showed that long-term improved hyperlocomotion impulsivity behaviors, memory performance This correlated with increased hippocampal inhibition structural improvements were associated BDNF levels. Given function, present findings support benefits as an adjuvant therapy for CDD.

Язык: Английский

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Identification and verification of genes associated with hypoxia microenvironment in Alzheimer's disease

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Июль 25, 2023

Abstract As the incidence of Alzheimer's disease (AD) increases year by year, more people begin to study this disease. In recent years, many studies on reactive oxygen species (ROS), neuroinflammation, autophagy, and other fields have confirmed that hypoxia is closely related AD. However, no researchers used bioinformatics methods relationship between AD hypoxia. Therefore, our aimed screen role hypoxia-related genes in clarify their diagnostic significance. A total 7681 differentially expressed (DEGs) were identified GSE33000 differential expression analysis cluster analysis. Weighted gene co-expression network (WGCNA) was detect 9 modules 205 hub with high correlation coefficients. Next, machine learning algorithms applied four key selected. Through verification external dataset quantitative real-time PCR (qRT-PCR), model established ANTXR2, BDNF NFKBIA. The results suggest may increase risk AD., in-depth are still needed investigate association, This article would guide insights directions for further research.

Язык: Английский

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