Trends in Stomach Cancer Burden in China: A Joinpoint and APC Analysis Based on GBD 2021 DOI Creative Commons
Xiangying Xie, Juan Su, Wei Wang

и другие.

Journal of Gastroenterology and Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

To study the corresponding strategies to control stomach cancer, a comprehensive assessment of disease burden is required. Herein, we present long-term trends in cancer China over past three decades, as well its epidemiological features. We characterized using GBD 2021 methods and results, based on prevalence, incidence, mortality, years life lost (YLLs), lived with disability (YLDs), disability-adjusted (DALYs) estimated DisMod-MR 2-1. also used joinpoint age-period-cohort (APC) analysis interpret characteristics project next decade, compare these global prevalence patterns. The age-standardized incidence (ASIR) mortality rates (ASMR) both sexes changed from 48.03 (40.21, 56.69) 29.05 (22.42, 36.2) 46.05 (38.88, 54.43) 21.51 (16.66, 26.61) per 100 000 people 1990 2021. DALY rate decreased 1181.61 (978.38, 1390.89) 501.26 (387.29, 627.98) average annual percentage change (AAPC) for were -1.61 (95% CI: -1.73, -1.48), -0.50 -0.67, -0.32), -2.44 -2.62, -2.26). effects age, period, cohort differed. In China's ASIR ASMR will continue decline. However, despite decrease overall remain significantly higher than average. be major public health challenge, given country's large population base aging population.

Язык: Английский

STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS DOI Creative Commons

Mohammad Qutub,

Amol Tatode,

Jayshree Taksande

и другие.

Aspects of Molecular Medicine, Год журнала: 2025, Номер 5, С. 100062 - 100062

Опубликована: Янв. 5, 2025

Процитировано

5
Pterostilbene in the treatment of inflammatory and oncological diseases DOI Creative Commons
Peijun Liu, Weihua Tang,

Kali Xiang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Pterostilbene (PTS), a naturally occurring analog of resveratrol (RSV), has garnered significant attention due to its potential therapeutic effects in treating inflammatory and oncological diseases. This comprehensive review elucidates the pharmacological properties, mechanisms action, PTS. Various studies indicate that PTS exhibits anti-inflammatory, antioxidant, antitumour potentially making it promising candidate for clinical applications. Its influence on regulatory pathways like NF-κB PI3K/Akt underscores diverse strategies addressing Additionally, showcases favorable pharmacokinetic profile with better oral bioavailability compared other stilbenoids, thus enhancing potential. Given these findings, there is an increased interest incorporating into treatment regimens cancer-related conditions. However, more extensive trials are imperative establish safety efficacy patient populations.

Язык: Английский

Процитировано

13
Metabolic dysfunction-associated steatotic liver disease and extrahepatic gastrointestinal cancers DOI
Alessandro Mantovani, Amedeo Lonardo, Norbert Stefan

и другие.

Metabolism, Год журнала: 2024, Номер 160, С. 156014 - 156014

Опубликована: Авг. 24, 2024

Язык: Английский

Процитировано

11
Association of VEGF promoter polymorphisms with gastrointestinal tract cancer risk and therapy response: a systematic review DOI Creative Commons

Deepanshi Mahajan,

Vasudha Sambyal, Kamlesh Guleria

и другие.

Egyptian Journal of Medical Human Genetics, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 20, 2025

Abstract Background Gastrointestinal tract (GIT) cancers are the most lethal with a high incidence and poor prognosis. Vascular endothelial growth factor (VEGF) glycoprotein plays an essential role in tumour neovascularization, especially of gastrointestinal tract. There numerous functional polymorphisms reported VEGF which lead to either upregulation or downregulation expression. Objective The present review focuses on influencing risk prognosis various GIT cancers. Method study This systematic was done by Preferred Reporting Items for Systematic Reviews Meta-analyses (PRISMA) guidelines, Participant, Intervention, Comparison, Outcomes Studies (PICOS) criteria were followed designing study. A total 183 articles retrieved from Google Scholar, PubMed ScienceDirect using keywords. After full-text evaluation applying literature selection criteria, 108 selected review. promoter transcription binding sites (TFBS) studied performing silico analysis. Results article summarized findings studies associations effect cancer varied between different ethnicities analysis revealed that alter TFBS, leading attenuation activity factors might have importance development. Conclusion is as important biomarker studying disease susceptibility, progression

Язык: Английский

Процитировано

1
Metabolic crossroads: unravelling immune cell dynamics in gastrointestinal cancer drug resistance DOI Open Access

C. Raman Suri,

Babita Pande,

Lakkakula Suhasini Sahithi

и другие.

Cancer Drug Resistance, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.

Язык: Английский

Процитировано

1
Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review) DOI Creative Commons

Ye Ding,

Yong Yu

Molecular Medicine Reports, Год журнала: 2025, Номер 31(4), С. 1 - 34

Опубликована: Фев. 24, 2025

Flavonoids are a group of polyphenolic compounds distributed in vegetables, fruits and other plants, which have considerable antioxidant, anti‑tumor anti‑inflammatory activities. Several types gastrointestinal (GI) cancer the most common malignant tumors world. A large number studies shown that flavonoids inhibitory effects on cancer, they recognized as class potential drugs. Therefore, present review investigated molecular mechanisms treatment different GI summarized drug delivery systems commonly used to improve their bioavailability. First, classification therapeutic various human diseases were briefly introduced. Then, clarify mechanism action body, metabolic process body associated signaling pathways causing five discussed, well corresponding targets flavonoids. Finally, clinical settings, poor water solubility, low permeability inferior stability, lead absorption efficiency vivo. three widely summarized. Suggestions for improving bioavailability focus next stage research also put forward.

Язык: Английский

Процитировано

1
Friend or Foe: Exploring the Relationship between the Gut Microbiota and the Pathogenesis and Treatment of Digestive Cancers DOI Creative Commons
Monica Profir,

Oana Roşu,

Sanda Maria Creţoiu

и другие.

Microorganisms, Год журнала: 2024, Номер 12(5), С. 955 - 955

Опубликована: Май 8, 2024

Digestive cancers are among the leading causes of cancer death in world. However, mechanisms development and progression not fully understood. Accumulating evidence recent years pointing to bidirectional interactions between gut dysbiosis a specific type gastrointestinal is shedding light on importance this “unseen organ”—the microbiota. This review focuses local role microbiota imbalance different digestive tract organs annexes related carcinogenic mechanisms. Microbiota modulation, either by probiotic administration or dietary changes, plays an important future therapies various cancers.

Язык: Английский

Процитировано

7
Gingerol: extraction methods, health implications, bioavailability and signaling pathways DOI Creative Commons
Mahesh Kumar Samota, Mandeep Rawat, Manpreet Kaur

и другие.

Sustainable Food Technology, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Ginger ( Zingiber officinale L. Z.o.) is a well-known spice that has been used for centuries as food ingredient and in traditional medicine.

Язык: Английский

Процитировано

6
Racial and Ethnic Disparities in Use of Colorectal Cancer Screening Among Adults With Chronic Medical Conditions: BRFSS 2012–2020 DOI Creative Commons
Maira A. Castañeda‐Avila, Mayra Tisminetzky, Atinuke G. Oyinbo

и другие.

Preventing Chronic Disease, Год журнала: 2024, Номер 21

Опубликована: Фев. 19, 2024

People with chronic conditions and people colorectal cancer (CRC) may share common risk factors; thus, CRC screening is important for conditions. We examined racial ethnic differences in the use of among various numbers

Язык: Английский

Процитировано

5
Association of dietary inflammatory index and dietary oxidative balance score with gastrointestinal cancers in NHANES 2005–2018 DOI Creative Commons
Yu Chang,

Chanjiao Yu,

Xianyu Dai

и другие.

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 9, 2024

Gastrointestinal (GI) cancers, including gastric, liver, esophageal, pancreatic, and colorectal represent significant global health burdens. Emerging evidence suggests that dietary patterns, particularly their inflammatory oxidative properties, may influence cancer risk. The Dietary Inflammatory Index (DII) Oxidative Balance Score (DOBS) assess the effects of diets, respectively. This study aims to explore association between DII, DOBS, combined risk GI investigates potential mediating roles serum albumin red cell distribution width (RDW).

Язык: Английский

Процитировано

5