Factors associated with frailty in older people: an umbrella review
BMC Geriatrics,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 5, 2024
Язык: Английский
Effect of a Supervised Aerobic Exercise Training Program and Ginkgo Biloba Extract on Metabolic Parameters and Functional Capacity in HIV-Infected Subjects
Healthcare,
Год журнала:
2025,
Номер
13(6), С. 663 - 663
Опубликована: Март 18, 2025
Background:
A
remarkable
increase
in
metabolic
comorbidities
occur
people
living
with
HIV
infection
(PLWH).
Supervised
physical
activity
provides
significant
health
benefits.
Ginkgo
biloba
(GKB)
extract
has
been
reported
to
have
a
wide
range
of
advantages.
This
study
aimed
examine
the
effects
an
exercise
training
(ET)
program
and
GKB
on
PLWH.
Methods:
was
randomized
placebo-controlled
double-blind
study.
Twenty-eight
PLWH
were
assigned
receive
placebo
(n
=
10),
or
statins
8).
All
patients
underwent
supervised
ET
3–5
times
per
week.
Anthropometric
measurements,
functional
capacities,
parameters
assessed
all
participants
at
baseline
after
12
weeks
follow-up.
Results:
After
12-week
intervention,
body
fat
decreased
significantly
by
2–3%
groups
relative
their
values
(p
<
0.05).
Total
cholesterol
LDL-c
+
statin
group
0.04,
p
0.007,
respectively)
compared
values,
while
HbA1c
HOMA-IR
index
0.03
0.02,
CD4+
T
cell
mean
observed
0.005)
values.
cardiorespiratory
capacity
(VO2max)
from
0.001)
intervention
Conclusions:
Body
fitness
improved
program.
insulin
resistance.
Язык: Английский
The effects of weight training and Aklil-ol-Malek on histopathology and C-Reactive Protein, Nuclear Factor Erythroid-Derived 2-Like 2Beta-Site Amyloid Precursor Protein Cleaving Enzyme1 genes Expression in Alzheimer’s disease model rats
Farah Nameni,
Mohammad Reza Amir Khan Dehkordi
Journal of Neurorestoratology,
Год журнала:
2025,
Номер
unknown, С. 100206 - 100206
Опубликована: Апрель 1, 2025
Язык: Английский
The longitudinal relations between physical activity, inflammation, and depression in the Health and Retirement Study
PLOS mental health.,
Год журнала:
2025,
Номер
2(4), С. e0000211 - e0000211
Опубликована: Апрель 24, 2025
Physical
activity
appears
associated
with
lower
depression
in
treatment
and
epidemiological
studies
but
specific
biological
mechanisms
remain
unclear.
Research
supports
inflammation
being
positively
negatively
physical
activity,
suggesting
it
could
mediate
activity’s
effect
on
depression.
This
study
examined
longitudinal
associations
between
inflammation,
symptoms
13,461
older
adults
(59%
women,
mean
age
=
68)
using
the
Health
Retirement
Study
dataset.
Depression,
(high
sensitivity
C-reactive
protein
(hsCRP))
were
measured
three
times,
four
years
apart.
We
used
random
intercept
cross-lagged
panel
models
(RI-CLPM)
to
test
for
stable
between-person
within-person
over
time.
Between-person
results
found
higher
was
hsCRP
(β
−0.40,
SE
0.087,
p
<
0.001)
scores
−0.48,
0.137,
0.001),
is
depressive
symptoms.
Conversely,
correlated
0.19,
0.20,
0.001).
Within-person
revealed
no
support
change
as
a
mediator
of
relation
Findings
suggest
robust
relations
among
trait
levels
depression,
little
association.
Future
additional
assessments
shorter
intervals
may
clarify
temporal
Язык: Английский
Association between Inflammation and New-Onset Atrial Fibrillation in Acute Coronary Syndromes
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(17), С. 5088 - 5088
Опубликована: Авг. 27, 2024
Acute
coronary
syndrome
(ACS)
is
a
complex
clinical
that
encompasses
acute
myocardial
infarction
(AMI)
and
unstable
angina
(UA).
Its
underlying
mechanism
refers
to
plaque
disruption,
with
consequent
platelet
aggregation
thrombosis.
Inflammation
plays
an
important
role
in
the
progression
of
atherosclerosis
by
mediating
removal
necrotic
tissue
following
shaping
repair
processes
are
essential
for
recovery
process
after
ACS.
As
chronic
inflammatory
disorder,
characterized
dysfunctional
immune
inflammation
involving
interactions
between
(macrophages,
T
lymphocytes,
monocytes)
vascular
cells
(endothelial
smooth
muscle
cells).
New-onset
atrial
fibrillation
(NOAF)
one
most
common
arrhythmic
complications
setting
syndromes,
especially
early
stages,
when
reaction
at
its
maximum.
The
main
changes
substrate
due
ischemia
infarcts
can
be
attributed
neurohormonal
factors.
high
incidence
(AF)
post-myocardial
may
secondary
inflammation.
Inflammatory
response
system
have
been
involved
initiation
development
fibrillation.
Several
indexes,
such
as
C-reactive
protein
interleukins,
demonstrated
predictive
prognosis
patients
cell
signaling
activation
patterns
associated
fibrosis,
apoptosis,
hypertrophy
forms
cardiac
remodeling
occur
level,
predisposing
AF.
According
recent
study,
presence
fibrosis
lymphomononuclear
infiltration
was
prior
history
However,
contribute
both
occurrence/maintenance
AF
thromboembolic
complications.
Язык: Английский
The Nutriepigenome
Genes,
Год журнала:
2023,
Номер
14(11), С. 1997 - 1997
Опубликована: Окт. 25, 2023
Unlike
genetic
changes,
epigenetics
modulates
gene
expression
without
stable
modification
of
the
genome.
Even
though
all
cells,
including
sperm
and
egg,
have
an
epigenome
pattern,
most
these
modifications
occur
during
lifetime
interestingly,
some
them,
are
reversible.
Lifestyle
especially
nutrients
as
well
diet
regimens
presently
gaining
importance
due
to
their
ability
affect
epigenome.
On
other
hand,
since
profoundly
affects
profile
it
can
be
speculated
that
could
modulate
individual
response
nutrients.
Recent
years
thus
seen
growing
interest
on
nutrients,
macronutrients
ratio
capable
epigenetic
pattern.
In
fact,
while
alterations
mostly
detrimental
at
level,
reshaping
may
a
feasible
strategy
positively
counteract
effect
aging.
Here,
I
review
nutrient
consumption
possible
aging-driven
derangement.
Язык: Английский
Plasminogen Activator Inhibitor‐1 in the Pathophysiology of Late Life Depression
International Journal of Geriatric Psychiatry,
Год журнала:
2024,
Номер
39(11)
Опубликована: Ноя. 1, 2024
ABSTRACT
Introduction
Late
life
depression
(LLD)
is
characterized
by
specific
clinical
features
including
a
high
frequency
of
vascular
form
and
frequent
antidepressant
treatment
resistance.
The
expression
functions
the
serine
protease
inhibitor,
Plasminogen
Activator
Inhibitor‐1
(PAI‐1)
known
to
be
altered
aging,
damage,
insulin
levels
associated
with
sedentary
lifestyle,
chronic
stress
leading
hypercortisolemia,
inflammatory
changes
linked
responses.
These
phenomena
would
implicated
in
LLD
like
depression.
This
article
thus
aims
review
existing
literature
regarding
association
between
plasmatic
PAI‐1,
marker
hypofibrinolysis.
We
hypothesize
that
increased
age
PAI‐1
plasma
level
function
which
influence
pathogenesis
its
treatment.
Results
Although
large
number
studies
on
elderly
exist,
about
implications
are
sparse.
Despite
heterogeneous
findings
direction
variation
among
participants
LLD,
all
demonstrated
an
current
or
remitted
depressive
symptoms.
Moreover,
disruptions
concentrations
other
biological
markers
influencing
expression,
such
as
cytokines
adipokines,
were
also
observed,
notably
increase
interleukins
6
8.
Discussion
genesis
appears
influenced
regulatory
loops
senescence
cell
death.
resistance
distinct
profiles
involving
fibrinolytic
factors.
Taken
together
these
data
suggest
pathway
may
promising
target
development
efforts
for
general.
Язык: Английский
The association between low skeletal muscle mass and immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
Abstract
Purpose
To
investigate
the
relationships
between
low
skeletal
muscle
mass
and
immunoinflammatory
markers
in
middle-aged
elderly
patients
with
type
2
diabetes
mellitus
(T2DM).
Methods
From
April
2022
to
May
2023,
978
T2DM
diagnosed
Department
of
Endocrinology
First
Hospital
Lanzhou
University
were
divided
into
a
group
normal
according
index,
compared
differences
groups.
The
above
grouped
quartile
levels,
prevalences
loss
among
groups;
relationship
index
was
analysed.
Results
Compared
group,
levels
all
indices
significantly
increased
(
P
<
0.05);
progressively
raised
increasing
each
marker.
independently
positively
correlated
risk
(NAR:
OR
=
2.148,
95%
CI
1.225–3.766,
0.008;
NLR:
1.210,
1.036–1.411,
0.016;
MLR:
1.282,
1.068–1.540,
SII:
1.001,
1.000
-1.002,
0.009;
SIRI:
1.828,
1.271–2.628,
0.001;
1.003,
1.001–1.004,
0.010)
.
Conclusions
occurrence
may
be
closely
related
immune
inflammation
patients.
Monitoring
is
clinical
value
for
early
screening
intervention
Язык: Английский
Association of Dietary Inflammation Index with sarcopenia in adult women with nonalcoholic fatty liver disease: based on the National Health and Nutrition Examination Survey Database
European Journal of Gastroenterology & Hepatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
Background
A
higher
Dietary
Inflammatory
Index
(DII)
is
linked
with
an
elevated
risk
of
sarcopenia,
but
the
relationship
between
two
in
adult
female
patients
nonalcoholic
fatty
liver
disease
(NAFLD)
remains
uncertain.
Objective
The
project
was
designed
to
probe
into
DII
and
sarcopenia
NAFLD
patients.
Methods
As
a
cross-sectional
study,
this
study
used
data
for
women
from
2017
2018
National
Health
Nutrition
Examination
Survey
(NHANES)
Database,
as
independent
variable
dependent
variable.
examined
by
utilizing
weighted
logistic
regression.
Restricted
cubic
splines
(RCS)
threshold
effect
models
were
further
employed
explore
nonlinear
two.
Results
We
included
469
patients,
whom
65
(10.2%)
sarcopenic.
In
great
positive
correlation
observed
logistics
regression
model
[odds
ratio
(OR):
1.459,
95%
confidence
interval
(CI):
1.013–2.103,
P
=
0.045].
RCS
curve
manifested
linear
(
0.751).
analysis
demonstrated
that
when
>
0,
positively
(OR:
1.328,
CI:
1.030–1.722,
0.030).
Conclusion
sarcopenia.
Future
research
should
mechanism
influence
on
evaluate
whether
improving
eating
habits
can
effectively
reduce
occurrence
NAFLD.
Язык: Английский