The impact of glucagon-like peptide-1 (GLP-1) agonists in the treatment of eating disorders: a systematic review and meta-analysis

Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity, Год журнала: 2025, Номер 30(1)

Опубликована: Фев. 1, 2025

Abstract Purpose Glucagon-like peptide-1 (GLP-1) receptor agonists have shown potential in managing eating disorders (EDs). Recent studies highlight their effects on pathophysiological pathways, indicating therapeutic promise, particularly for binge disorder (BED). This systematic review evaluates the of GLP-1 BED, focusing weight management and behaviors. Methods A search PubMed, Scopus, Web Science, Cochrane Library, along with manual searches, identified assessing BED patients up to November 8, 2024. Observational clinical trials meeting inclusion criteria were analyzed. Results Five (182 participants) included. Patients receiving experienced greater loss (− 3.81 kg; 95% CI − 5.14 2.49; p < 0.01, I 2 : 59.88%) compared controls. significantly reduced BMI 1.48 kg/m ) waist circumference 3.14 cm). Binge Eating Scale (BES) scores improved 8.14 points; 13.13 3.15; 0.01), though heterogeneity was noted. Conclusions underscores role management. However, given limited data, especially concerning EDs other than long-term these medications, further comprehensive are recommended evaluate impact various different across diverse demographic groups. Level evidence I, randomized controlled trials.

Язык: Английский

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Intelligent Internet of Medical Things for Depression: Current Advancements, Challenges, and Trends

International Journal of Intelligent Systems, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

We investigated the fusion of Intelligent Internet Medical Things (IIoMT) with depression management, aiming to autonomously identify, monitor, and offer accurate advice without direct professional intervention. Addressing pivotal questions regarding IIoMT’s role in identification, its correlation stress anxiety, impact machine learning (ML) deep (DL) on depressive disorders, challenges potential prospects integrating management IIoMT, this research offers significant contributions. It integrates artificial intelligence (AI) (IoT) paradigms expand studies, highlighting data science modeling’s practical application for intelligent service delivery real‐world settings, emphasizing benefits within IoT. Furthermore, it outlines an IIoMT architecture gathering, analyzing, preempting employing advanced analytics enhance intelligence. The study also identifies current challenges, future trajectories, solutions domain, contributing scientific understanding management. evaluates 168 closely related articles from various databases, including Web Science (WoS) Google Scholar, after rejection repeated books. shows that there is 48% growth articles, mainly focusing symptoms, detection, classification. Similarly, most being conducted United States America, trend increasing other countries around globe. These results suggest essence automated monitoring, suggestions handling depression.

Язык: Английский

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Sensory processing across eating disorders: A systematic review and meta‐analysis of self‐report inventories

International Journal of Eating Disorders, Год журнала: 2024, Номер 57(7), С. 1465 - 1488

Опубликована: Март 21, 2024

Abstract Objective This review investigated the extant literature regarding relationship between eating disorder diagnoses and sensory processing as measured by validated reliable self‐report inventories. Increasing evidence highlights role of in cognitive functions. Sensory is implicated mental‐ill health, including disorders (ED) body image disturbances. However, pathophysiological underpinnings processing, encompassing exteroception interoception, relation to ED remain underexplored. Method We included studies involving participants aged 15 years or older with an diagnosis confirmed semi‐structured structured interviews. further limited inclusion articles using instruments measure processing. Our meta‐analysis focused on interoceptive awareness subscale from second version Eating Disorder Inventory. used Critical Appraisal checklist for quasi‐experimental assess quality articles. Results There were 19 that met our criteria. Most showed moderate‐to‐high quality. Anorexia nervosa (AN) bulimia (BN) associated heightened exteroception. Moreover, people AN reported a sense taste compared those BN. comprising 10 studies, samples, 6382 revealed (binge‐purge subtype) BN increased difficulties (restrictive binge‐eating disorder. Discussion Overall, this emphasizes need deeper investigation into spanning both ED. may prove important individualizing person‐centered care. Public significance How process internal, example, hunger, external, sensations known influence cognition ways which contribute are incompletely understood. found individuals experienced exteroception, while characterized purging difficulties. These patterns could inform development more personalized treatments.

Язык: Английский

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Unlocking the Link Between Gut Microbiota and Psychopathological Insights in Anorexia Nervosa: A Systematic Review

European Eating Disorders Review, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

This systematic review explores the associations between qualitative/quantitative changes in gut microbiota and psychopathological symptoms or other clinical features patients with eating disorders (EDs). Secondary outcomes include exploring EDs potential relationships psychotropic drug use. A search was conducted across biomedical databases from inception to June 2024 according PRISMA guidelines. The risk of bias assessed, a narrative synthesis performed due heterogeneity outcomes. Only findings related anorexia nervosa (AN) were identified. Ten studies, which seven longitudinal, two cross-sectional, one interventional (N = 350 AN, 304 HCs), included. Despite no clear links diversity metrics being observed, specific taxa belonging phylum Firmicutes, such as Clostridium, Roseburia, Lactobacillus, Faecalibacterium, Bifidobacterium Actinobacteriota correlated ED psychopathology, including anxiety depressive symptoms. Changes symptoms, well altered behaviours by modulating inflammation insulin pathways through short-chain fatty acids (SCFAs), that also lead neurotransmitter imbalances. Further studies are required replicate these finding explore whether similar patterns observed EDs.

Язык: Английский

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Look at My Body: It Tells of Suffering—Understanding Psychiatric Pathology in Patients Who Suffer from Headaches, Restrictive Eating Disorders, or Non-Suicidal Self-Injuries (NSSIs)

Pediatric Reports, Год журнала: 2025, Номер 17(1), С. 21 - 21

Опубликована: Фев. 8, 2025

Background/Objectives: Adolescence is a developmental stage characterized by profound physical and psychological transformations, often leading to vulnerabilities such as body dissatisfaction, identity challenges, the use of maladaptive coping strategies. This leads body-related psychopathologies, including headaches, restrictive eating disorders, non-suicidal self-injury (NSSI). The present study aimed describe typical functioning features these conditions differences between three groups, identify most effective assessment for predicting conditions. Methods: Sixty adolescent patients (51 female; mean age = 15.34 ± 1.80) were divided into groups: NSSI, assessed in symptoms, cognitive performance, personality, functioning, illness severity using semi-structured interviews, clinician-based scales, performance-based tests like Rorschach inkblot test, according Performance Assessment System (R-PAS). Results: Individuals with headaches experienced more internalizing had an average IQ, maintained some areas, distorted patterns self–other relationships tendency project malevolent aspects onto others. Patients disorders high levels depressive above-average IQ scores, negative moderate presence obsessive–compulsive personality traits, disorganized thinking, interpret situations subjectively. NSSI showed highest level symptoms social anxiety considerable psychotic perceptual distortions. Negative borderline psychosis strongest predictivity. Conclusions: provides clinicians relevant insights highlights strategies, tailored interventions, enhanced outcomes vulnerable populations.

Язык: Английский

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A Comprehensive Analysis of the Impact of Binge Eating Disorders on Lifestyle in Spain

Psychiatry International, Год журнала: 2025, Номер 6(1), С. 24 - 24

Опубликована: Март 3, 2025

Background/Objectives: Binge Eating Disorders are severe mental and physical health conditions, closely linked to lifestyle habits. The aims describe the prevalence of their correlation with nutritional habits factors within Spanish population. Methods: A descriptive, cross-sectional design was employed. Using non-probabilistic snowball sampling, an electronic survey released. total 22,181 adults were evaluated, excluding those any pathology or limitation at time response that could potentially affect diet, such as hospitalization confinement. validated Nutritional Social Healthy Habits (NutSo-HH) scale used collect data on nutrition, lifestyle, habits, socio-demographic variables. Descriptive inferential statistics used. Non-parametric tests applied due non-normal distribution. Results: Of sample subject (80.8% female), a number 260 individuals reported Disorder. Disorder higher in women than men (239 vs. 21 respectfully; 91.9%). Individuals exhibited poorer indices (p < 0.001), consumption ultra-processed fast food sugary soft drinks = 0.01), worse sleep quality 0.001). Although dedicated activity not different, more sedentary had lower status 0.11 for sport practice). Behavioral regulation plays key role managing BED, highlighting need personalized intervention strategies. Conclusions: associated life. These can help public programs early detection effective treatment.

Язык: Английский

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Exploring the Role of Psychedelic Experiences on Wellbeing and Symptoms of Disordered Eating

Psychoactives, Год журнала: 2025, Номер 4(1), С. 7 - 7

Опубликована: Март 4, 2025

Accumulating psychedelic research has demonstrated a potential for improving mental health and wellbeing, yet studies in the context of eating disorders (EDs) are limited. This study aims to explore subjective effects experiences gain insight into benefits risks people with EDs. Semi-structured interviews were conducted eight adults aged 25–54 (mean age = 36.9), reporting have had EDs psychedelics both naturalistic clinical settings. Participants multiple diagnoses suffered chronic EDs, onset 13), diagnosed (N 7) undiagnosed 1). Reports cessation or reduction ED symptoms unanimous long-lasting seven, two participants recovery attributed use. Two reported relapsing, environmental factors months following. Thematic analysis resulted superordinate themes, each comprising three subordinate themes. The first theme, ‘Exploring’ via ‘gateway healing’, illustrates mental, emotional, transcendental elements experiences. second ‘Transformation’ being ‘able do work’, cognitive behavioural outcomes, retrospective safety perceptions. These findings may provide more in-depth information on what can obtain from use drugs inform robust investigations psychedelic-assisted therapy treatment

Язык: Английский

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Therapie von Essstörungen

Ernährung & Medizin, Год журнала: 2025, Номер 40(01), С. 14 - 18

Опубликована: Март 1, 2025

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Eating disorder risk in adult women: the role of social physique anxiety and emotional eating

Current Psychology, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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Screening of the Risk of Eating Disorders Among Medical Students in the MENA region and Its Associated Factors: A Multinational Cross‐Sectional Study

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT Background Eating disorders (EDs) are a group of mental diseases marked by disrupted eating behaviors, and associated with several factors. Medical students highly exposed to this disorder prevalence 17.35% in 2022. Objective To evaluate the risk EDs its factors among medical Middle East North Africa (MENA) region. Methods A web‐based cross‐sectional study was conducted MENA region during months June July 2024. The primary data collection instrument comprehensive questionnaire that contained Attitudes Test (EAT‐26) sociodemographic clinical features designed using Google Forms distributed via social media platforms. Results total number participants 5061. mean age our population 22.58 ± 3.27. Our population's average EAT‐26 score 13.87 10.7, ranges varying from 0 72. Based on their scores being 20 or above, 1254 people (24.8%) were deemed be at EDs. Among participants, 8% underweight. multivariable logistic regression model revealed such as T1DM, schizophrenia, autism, female gender, IBD, daily exposure thin body ideal. Regular sports practice weight satisfaction protective Conclusion There exists higher individuals for development especially females, comorbidities, those having conflictual relationships parents.

Язык: Английский

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