Bactericidal and Cytotoxic Properties of Silver Nanoparticles

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(2), С. 449 - 449

Опубликована: Янв. 21, 2019

Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic healthcare products, antimicrobial textiles, wound dressings, antitumor drug carriers, etc. due to their excellent properties. Accordingly, AgNPs gained access into our daily life, the inevitable human exposure these has raised concerns about potential hazards environment, health, safety in recent years. From vitro cell cultivation tests, reported toxic several lines bronchial epithelial cells, umbilical vein endothelial red blood peripheral mononuclear immortal keratinocytes, liver induce dose-, size- time-dependent cytotoxicity, particularly those with sizes ≤10 nm. Furthermore, cross brain barrier mice through circulation system on basis vivo animal tests. tend accumulate organs such liver, spleen, kidney following intravenous, intraperitoneal, intratracheal routes administration. In this respect, are considered double-edged sword that eliminate microorganisms but cytotoxicity mammalian cells. This article provides state-of-the-art review synthesis AgNPs, applications textile fabrics, food packaging films, dressings. Particular attention is paid bactericidal activity cytotoxic effect

Язык: Английский

---

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(7), С. 2375 - 2375

Опубликована: Март 30, 2020

Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among various ENMs, silver nanoparticles (AgNPs) become one of most explored nanotechnology-derived nanostructures and been intensively investigated for their unique physicochemical properties. The widespread commercial biomedical application nanosilver include its use as a catalyst an optical receptor cosmetics, electronics textile engineering, bactericidal agent, wound dressings, surgical instruments, disinfectants. This, turn, has increased potential interactions AgNPs with terrestrial aquatic environments, well exposure toxicity to human health. In present review, after giving overview we discuss current advances on physiochemical properties specific emphasis biodistribution both vitro vivo following routes exposure. Most studies demonstrated size-, dose- coating-dependent cellular uptake AgNPs. Following NPs exposure, reported Ag accumulation local distant organs. Though there increase number this area, more investigations are required understand mechanisms modes

Язык: Английский

---

<p>Green nanotechnology: a review on green synthesis of silver nanoparticles — an ecofriendly approach</p>

International Journal of Nanomedicine, Год журнала: 2019, Номер Volume 14, С. 5087 - 5107

Опубликована: Июль 1, 2019

Nanotechnology explores a variety of promising approaches in the area material sciences on molecular level, and silver nanoparticles (AgNPs) are leading interest present scenario. This review is comprehensive contribution field green synthesis, characterization, biological activities AgNPs using different sources.

Язык: Английский

---

ROS Homeostasis in Abiotic Stress Tolerance in Plants

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(15), С. 5208 - 5208

Опубликована: Июль 23, 2020

Climate change-induced abiotic stress results in crop yield and production losses. These stresses result changes at the physiological molecular level that affect development growth of plant. Reactive oxygen species (ROS) is formed high levels due to within different organelles, leading cellular damage. Plants have evolved mechanisms control scavenging ROS through enzymatic non-enzymatic antioxidative processes. However, has a dual function where, levels, they are toxic cells while same molecule can as signal transducer activates local systemic plant defense response against stress. The effects, perception, signaling, activation their responses elaborated this review. This review aims provide purview processes involved homeostasis plants identify genes triggered abiotic-induced oxidative articulates importance these pathways understanding mechanism resistance information breeding genetically developing crops for plants.

Язык: Английский

---

Advances in controlled release pesticide formulations: Prospects to safer integrated pest management and sustainable agriculture

Journal of Hazardous Materials, Год журнала: 2019, Номер 385, С. 121525 - 121525

Опубликована: Ноя. 2, 2019

Язык: Английский

---

Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components

Materials Today Communications, Год журнала: 2020, Номер 25, С. 101692 - 101692

Опубликована: Сен. 20, 2020

The utilization of nanomaterials in the biological and medical field is quickly progressing, particularly areas where traditional diagnostics treatment approaches have limited success. success products such as biomedical implants, wound dressings drug delivery systems rely upon their effective interaction between extracellular matrix, cells, intracellular components. Upon contact with mammalian nanoparticles (NPs) begin to interact cell membrane, cytoplasmic proteins, nucleus, other cellular organelles, which result nanoparticle internalization subsequent responses. Such responses elicited by cells a cell-nanomaterials interactions, both at molecular level, are mainly determined morphological, chemical, surface characteristics themselves. This review provides an overview how different attributes, chemical nature, size, shape, charge, topography, stiffness, functional features nanomaterials, influence interactions.

Язык: Английский

---

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review

Journal of Nanoparticle Research, Год журнала: 2023, Номер 25(3)

Опубликована: Фев. 27, 2023

Rapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active toxic due to the greater surface area small size. Understanding NPs' mechanism of toxicity, together factors influencing behavior biological environments, can help researchers design reduced side effects improved performance. After overviewing classification properties NPs, this review article discusses molecular imaging cell therapy, gene transfer, tissue engineering, targeted drug delivery, Anti-SARS-CoV-2 vaccines, cancer treatment, wound healing, anti-bacterial applications. There different mechanisms toxicity behaviors depend on various factors, which elaborated article. More specifically, interactions living components discussed by considering impact physiochemical parameters such as size, shape, structure, agglomeration state, charge, wettability, dose, substance type. The polymeric, silica-based, carbon-based, metallic-based (including plasmonic alloy NPs) have been considered separately.

Язык: Английский

---

Effect of Size, Shape and Surface Functionalization on the Antibacterial Activity of Silver Nanoparticles

Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(5), С. 244 - 244

Опубликована: Апрель 26, 2023

Silver nanoparticles (AgNPs) are the most investigated antibacterial agents against multidrug resistant (MDR) pathogens. They can lead to cellular death by means of different mechanisms, damaging several cell compartments, from external membrane, enzymes, DNA and proteins; this simultaneous attack amplifies toxic effect on bacteria with respect traditional antibiotics. The effectiveness AgNPs MDR is strongly correlated their chemical morphological properties, which influence pathways involved in damage. In review, AgNPs’ size, shape modification functional groups or other materials reported, both investigate synthetic nanoparticles’ modifications evaluate related activity. Indeed, understanding conditions for obtaining performing could help tailor new improved silver-based combat resistance.

Язык: Английский

---

Nanoparticles in Agroindustry: Applications, Toxicity, Challenges, and Trends

Nanomaterials, Год журнала: 2020, Номер 10(9), С. 1654 - 1654

Опубликована: Авг. 23, 2020

Nanotechnology is a tool that in the last decade has demonstrated multiple applications several sectors, including agroindustry. There been an advance development of nanoparticulated systems to be used as fertilizers, pesticides, herbicides, sensors, and quality stimulants, among other applications. The nanoencapsulation process not only protects active ingredient but also can affect diffusion, interaction, activity. It important evaluate negative aspects use nanoparticles (NPs) agriculture. Given high impact agro-industrial field, this review aims address effects various nanomaterials on morphology, metabolomics, genetic modification crops.

Язык: Английский

---

Nanoparticle Toxicology

The Annual Review of Pharmacology and Toxicology, Год журнала: 2020, Номер 61(1), С. 269 - 289

Опубликована: Авг. 25, 2020

Nanoparticles from natural and anthropogenic sources are abundant in the environment, thus human exposure to nanoparticles is inevitable. Due this constant exposure, it critically important understand potential acute chronic adverse effects that may cause humans. In review, we explore highlight current state of nanotoxicology research with a focus on mechanistic understanding nanoparticle toxicity at organ, tissue, cell, biomolecular levels. We discuss nanotoxicity mechanisms, including generation reactive oxygen species, disintegration, modulation cell signaling pathways, protein corona formation, poly(ethylene glycol)-mediated immunogenicity. conclude perspective approaches advance toxicity. Such improved lead mitigation strategies could enable safe application Advances will ultimately inform efforts establish standardized regulatory frameworks goal fully exploiting nanotechnology while minimizing harm

Язык: Английский

---