Therapeutic Advances in Medical Oncology,
Год журнала:
2019,
Номер
11
Опубликована: Янв. 1, 2019
Tissue
inhibitor
of
metalloproteinase-3
(TIMP-3),
a
secreted
glycoprotein,
plays
an
important
role
in
carcinogenesis.
It
can
bind
to
many
proteinases
suppress
their
activity
and
thus
protect
the
extracellular
matrix
from
degradation.
TIMP-3
may
have
anticancer
properties,
including
apoptosis
induction
antiproliferative,
antiangiogenic,
antimetastatic
activities.
This
review
summarizes
structure,
proteinase
inhibition
ability,
genetic
epigenetic
regulation,
cancer
therapy
potential,
contribution
development
TIMP-3.
Furthermore,
this
we
discuss
its
potential
as
biomarker
for
predicting
progression
current
state
drugs
that
target
TIMP-3,
either
alone
or
combination
with
clinical
treatment.
In
conclusion,
be
therapy.
article
serve
basis
understand
how
modulate
levels
drug
cancers.
Abstract
The
inflammatory
response
is
induced
by
the
overexpression
of
cytokines,
mainly
interleukin
(IL)-1β,
and
one
main
causes
intervertebral
disc
degeneration
(IVDD).
NLR
pyrin
domain
containing
3
(NLRP3)
inflammasome
activation
an
important
source
IL-1β.
As
anti-inflammatory
neuroendocrine
hormone,
melatonin
plays
various
roles
in
different
pathophysiological
conditions.
However,
its
IVDD
are
still
not
well
understood
require
more
examination.
First,
we
demonstrated
that
delayed
progression
relieved
IVDD-related
low
back
pain
a
rat
needle
puncture
model;
moreover,
NLRP3
(NLRP3,
p20,
IL-1β
levels)
was
significantly
upregulated
severely
degenerated
human
discs
model.
Subsequently,
IL-1β/NF-κB-NLRP3
positive
feedback
loop
found
nucleus
pulposus
(NP)
cells
were
treated
with
In
these
cells,
expression
p20
increased,
NF-κB
signaling
involved
this
regulation,
mitochondrial
reactive
oxygen
species
(mtROS)
production
increased.
Furthermore,
disrupted
vitro
vivo.
Melatonin
treatment
decreased
NLRP3,
levels
inhibiting
downregulating
mtROS
production.
Finally,
showed
mediated
disruption
study,
for
first
time
promotes
own
upregulating
activation.
disrupts
may
be
potential
therapeutic
agent
IVDD.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(3), С. 1135 - 1135
Опубликована: Фев. 8, 2020
Melatonin
is
probably
produced
in
all
cells
but
only
secreted
by
the
pineal
gland.
The
secretion
of
melatonin
determined
light–dark
cycle,
and
it
released
at
night.
regulates
biological
rhythms
via
its
receptors
located
suprachiasmatic
nuclei
hypothalamus.
also
has
strong
antioxidant
activities
to
scavenge
free
radicals
such
as
reactive
oxygen
species
(ROS).
direct
radical
scavenging
actions
are
receptor
independent.
ROS
play
an
important
role
reproductive
function
including
ovulatory
process.
However,
excessive
can
have
adverse
effect
on
oocytes
because
oxidative
stress,
thereby
causing
infertility.
It
becoming
clear
that
ovarian
follicular
fluid
themselves,
which
protects
these
from
damage
well
having
other
beneficial
oocyte
maturation,
fertilization,
embryo
development.
Trials
humans
investigated
improvement
outcomes
assisted
technology
(ART),
vitro
fertilization
transfer
(IVF-ET),
way
administering
patients
suffering
In
addition,
clinical
research
examined
anti-aging
molecule
antioxidative
actions,
relationship
with
aging
diseases,
e.g.,
Alzheimer’s
Parkinson’s
disease,
underway.
may
reduce
aging,
a
major
issue
technology.
This
review
explains
between
human
function,
applications
expected
improve
IVF,
while
discussing
possibilities
for
preventing
aging.
International Journal of Molecular Sciences,
Год журнала:
2017,
Номер
18(9), С. 1913 - 1913
Опубликована: Сен. 6, 2017
Melatonin
is
an
indolic
hormone
that
regulates
a
plethora
of
functions
ranging
from
the
regulation
circadian
rhythms
and
antioxidant
properties
to
induction
maintenance
tumor
suppressor
pathways.
It
binds
specific
receptors
as
well
some
cytosolic
proteins,
leading
several
cellular
signaling
cascades.
Recently,
involvement
melatonin
in
cancer
insurgence
progression
has
clearly
been
demonstrated.
In
this
review,
we
will
first
describe
structure
its
receptors,
then
discuss
both
molecular
epidemiological
evidence
on
anticancer
effects.
Finally,
shed
light
potential
cross-talk
between
Hippo
pathway,
along
with
possible
implications
for
therapy.
Molecules,
Год журнала:
2021,
Номер
26(9), С. 2506 - 2506
Опубликована: Апрель 25, 2021
Melatonin
is
a
pleotropic
molecule
with
numerous
biological
activities.
Epidemiological
and
experimental
studies
have
documented
that
melatonin
could
inhibit
different
types
of
cancer
in
vitro
vivo.
Results
showed
the
involvement
anticancer
mechanisms
including
apoptosis
induction,
cell
proliferation
inhibition,
reduction
tumor
growth
metastases,
side
effects
associated
chemotherapy
radiotherapy,
decreasing
drug
resistance
therapy,
augmentation
therapeutic
conventional
therapies.
Clinical
trials
revealed
an
effective
adjuvant
to
all
This
review
summarized
biosynthesis,
availability
from
natural
sources,
metabolism,
bioavailability,
melatonin,
its
use
clinical
trials,
pharmaceutical
formulation.
Studies
discussed
this
will
provide
solid
foundation
for
researchers
physicians
design
develop
new
therapies
treat
prevent
using
melatonin.
