Therapeutic Advances in Medical Oncology,
Год журнала:
2019,
Номер
11
Опубликована: Янв. 1, 2019
Tissue
inhibitor
of
metalloproteinase-3
(TIMP-3),
a
secreted
glycoprotein,
plays
an
important
role
in
carcinogenesis.
It
can
bind
to
many
proteinases
suppress
their
activity
and
thus
protect
the
extracellular
matrix
from
degradation.
TIMP-3
may
have
anticancer
properties,
including
apoptosis
induction
antiproliferative,
antiangiogenic,
antimetastatic
activities.
This
review
summarizes
structure,
proteinase
inhibition
ability,
genetic
epigenetic
regulation,
cancer
therapy
potential,
contribution
development
TIMP-3.
Furthermore,
this
we
discuss
its
potential
as
biomarker
for
predicting
progression
current
state
drugs
that
target
TIMP-3,
either
alone
or
combination
with
clinical
treatment.
In
conclusion,
be
therapy.
article
serve
basis
understand
how
modulate
levels
drug
cancers.
IntechOpen eBooks,
Год журнала:
2018,
Номер
unknown
Опубликована: Ноя. 21, 2018
Melatonin
is
an
endogenous
hormone
derived
from
tryptophan
that
mainly
released
the
pineal
gland
in
dark.
regulates
many
biological
functions
such
as
sleep,
circadian
rhythm,
immunity,
and
reproduction.
has
a
free
radical
scavenger,
anti-inflammatory,
antioxidant
effects.
It
scavenges
reactive
oxygen
nitrogen
species
increases
defenses,
thus
it
prevents
tissue
damage
blocks
transcriptional
factors
of
pro-inflammatory
cytokines.
Due
to
its
small
size
amphiphilic
nature,
efficacy
mitochondrial
electron
transport
chain
reduces
leakage.
degenerative
changes
central
nervous
system
models
Alzheimer's
Parkinson's
disease
DNA
which
may
lead
cancer
other
situations.
Consequently,
melatonin
beneficial
effects
including
stimulation
enzymes,
inhibition
lipid
peroxidation,
so
contributes
protection
oxidative
damages.
International Journal of Molecular Medicine,
Год журнала:
2018,
Номер
unknown
Опубликована: Дек. 10, 2018
Angiogenesis
is
an
essential
process
involved
in
various
physiological,
including
placentation,
and
pathological,
cancer
endometriosis,
processes.
Melatonin
(MLT),
a
well‑known
natural
hormone
secreted
primarily
the
pineal
gland,
regulating
neoangiogenesis
inhibiting
development
of
variety
types,
lung
breast
cancer.
However,
specific
mechanism
its
anti‑angiogenesis
activity
has
not
been
systematically
elucidated.
In
present
study,
effect
MLT
on
viability
angiogenesis
human
umbilical
vein
endothelial
cells
(HUVECs),
production
vascular
growth
factor
(VEGF)
reactive
oxygen
species
(ROS),
under
normoxia
or
hypoxia
was
analyzed
using
Cell
Counting
kit
8,
tube
formation,
flow
cytometry,
ELISA
western
blot
assays.
It
determined
that
secretion
VEGF
by
HUVECs
significantly
increased
hypoxia,
while
selectively
obstructed
release
as
well
ROS
hypoxia.
Furthermore,
inhibited
dose‑dependent
manner
reversed
increase
cell
formation
induced
hypoxia/VEGF/H2O2.
Additionally,
treatment
with
inhibitor
inducible
(HIF)‑1α
(KC7F2)
synergistically
reduced
VEGF,
HUVECs.
These
observations
demonstrate
may
serve
dual
roles
inhibition
angiogenesis,
antioxidant
free
radical
scavenging
agent.
suppresses
through
downregulation
HIF‑1α/ROS/VEGF.
summary,
data
indicate
be
potential
anticancer
agent
solid
tumors
abundant
blood
vessels,
particularly
combined
KC7F2.
Theranostics,
Год журнала:
2020,
Номер
10(23), С. 10697 - 10711
Опубликована: Янв. 1, 2020
Background:
Emergence,
prevalence
and
widely
spread
of
plasmid-mediated
colistin
resistance
in
Enterobacteriaceae
strongly
impairs
the
clinical
efficacy
against
life-threatening
bacterial
infections.
Combinations
antibiotics
FDA-approved
non-antibiotic
agents
represent
a
promising
means
to
address
widespread
emergence
antibiotic-resistant
pathogens.
Methods:
Herein,
we
investigated
synergistic
activity
between
melatonin
MCR
(mobilized
resistance)-positive
Gram-negative
pathogens
through
checkerboard
assay
time-killing
curve.
Molecular
mechanisms
underlying
its
mode
action
were
elucidated.
Finally,
assessed
vivo
combination
with
drug-resistant
bacteria.
Results:
Melatonin,
which
has
been
approved
for
treating
sleep
disturbances
circadian
disorders,
substantially
potentiates
three
antibiotics,
particularly
colistin,
MCR-expressing
without
enhancing
toxicity.
This
is
evidence
that
enhances
outer
membrane
permeability,
promotes
oxidative
damage
inhibits
effect
efflux
pumps.
In
animal
models
infected
by
mcr-1-carrying
E.
coli,
dramatically
rescues
efficacy.
Conclusion:
Our
findings
revealed
serves
as
adjuvant
MCR-positive
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
144, С. 112001 - 112001
Опубликована: Окт. 6, 2021
Melatonin,
mostly
released
by
the
pineal
gland,
is
a
circadian
rhythm-regulated
and
multifunctional
hormone.
Great
advances
in
melatonin
research
have
been
made,
including
its
role
rhythms
of
sleep-wake
cycle,
retardation
ageing
processes,
as
well
antioxidant
or
anti-inflammatory
functions.
Melatonin
can
scavenge
free
radicals
such
reactive
oxygen
species
(ROS),
key
factor
reproductive
plays
an
important
oocyte
maturation,
fertilization
embryonic
development
well.
The
concurrent
use
increases
number
mature
oocytes,
rate,
high-quality
embryos,
which
improves
clinical
outcome
assisted
technology
(ART).
This
review
discusses
relationship
between
human
function,
potential
applications
field
medicine.
Therapeutic Advances in Medical Oncology,
Год журнала:
2019,
Номер
11
Опубликована: Янв. 1, 2019
Tissue
inhibitor
of
metalloproteinase-3
(TIMP-3),
a
secreted
glycoprotein,
plays
an
important
role
in
carcinogenesis.
It
can
bind
to
many
proteinases
suppress
their
activity
and
thus
protect
the
extracellular
matrix
from
degradation.
TIMP-3
may
have
anticancer
properties,
including
apoptosis
induction
antiproliferative,
antiangiogenic,
antimetastatic
activities.
This
review
summarizes
structure,
proteinase
inhibition
ability,
genetic
epigenetic
regulation,
cancer
therapy
potential,
contribution
development
TIMP-3.
Furthermore,
this
we
discuss
its
potential
as
biomarker
for
predicting
progression
current
state
drugs
that
target
TIMP-3,
either
alone
or
combination
with
clinical
treatment.
In
conclusion,
be
therapy.
article
serve
basis
understand
how
modulate
levels
drug
cancers.
