European Journal of Neuroscience,
Год журнала:
2020,
Номер
52(8), С. 3944 - 3950
Опубликована: Апрель 23, 2020
Abstract
Obesity
is
a
complex,
chronic,
and
multifactorial
condition
characterized
by
abnormal
fat
accumulation
in
tissues
organs
inducing
negative
effects
on
human
health.
Alzheimer's
disease
progressive
irreversible
neurodegenerative
disease,
associated
with
amyloid
plaques
neurofibrillary
tangles
the
brain.
The
correlation
between
obesity
has
been
discovered,
but
molecules
molecular
mechanisms
linking
these
conditions
are
not
yet
fully
elucidated.
In
this
review,
we
focused
most
important
processes
alterations
of
brain
structure
functions.
Journal of Clinical Medicine,
Год журнала:
2019,
Номер
8(6), С. 840 - 840
Опубликована: Июнь 12, 2019
This
study
is
the
first
to
evaluate
oxidative
stress
biomarkers
in
saliva/blood
of
patients
with
varying
degrees
dementia
progression.
The
included
50
healthy
controls
and
divided
into
two
groups:
those
mild
moderate
(MMSE
11-23)
suffering
from
severe
0-10).
Cognitive
functions
subjects
were
assessed
using
Mini
Mental
State
Examination
(MMSE).
Enzymatic
non-enzymatic
antioxidants,
damage
products
protein
glycoxidative
modifications
determined
non-stimulated
(NWS)
stimulated
(SWS)
saliva
as
well
erythrocyte/plasma
samples.
Generally,
patients,
we
observed
depletion
antioxidant
defences
leading
NWS,
SWS
blood
Both
salivary
increased
severity
disease,
correlated
a
decrease
cognitive
functions.
Interestingly,
reduced
glutathione
(GSH)
NWS
not
only
dementia,
but
also
GSH
concentration
plasma.
In
receiver
operating
characteristic
(ROC)
analysis,
have
demonstrated
that
clearly
distinguishes
or
(area
under
curve
(AUC)
=
1).
Therefore,
can
be
used
non-invasive
biomarker
impairment.
Frontiers in Neuroscience,
Год журнала:
2020,
Номер
14
Опубликована: Июль 8, 2020
Down
syndrome
(DS)
is
the
most
frequent
chromosomal
abnormality
that
causes
intellectual
disability,
resulting
from
presence
of
an
extra
complete
or
segment
chromosome
21
(HSA21).
In
addition,
trisomy
HSA21
contributes
to
altered
energy
metabolism
appears
be
a
strong
determinant
in
development
pathological
phenotypes
associated
with
DS.
Alterations
include
mitochondrial
defects,
increased
oxidative
stress
levels,
impaired
glucose
and
lipid
among
others,
finally
reduced
production
cellular
dysfunctions.
These
molecular
defects
seem
account
for
high
incidence
metabolic
disorders,
i.e.,
diabetes
and/or
obesity
as
well
higher
risk
develop
Alzheimer
disease
(AD)
A
dysregulation
insulin
signaling
downstream
pathways
represents
common
pathophysiological
aspect
both
peripheral
central
alterations
leading
diabetes/obesity
AD.
This
further
strengthened
by
evidence
showing
mechanisms
responsible
such
appear
similar
between
organs
brain.
Considering
DS
subjects
are
at
either
brain
this
review
will
discuss
current
knowledge
about
link
insulin-related
Drawing
signature
underlying
these
processes
key
challenge
identify
novel
drug
targets
set-up
new
prevention
strategies
aimed
reduce
impact
disorders
cognitive
decline.
European Journal of Neuroscience,
Год журнала:
2020,
Номер
52(8), С. 3944 - 3950
Опубликована: Апрель 23, 2020
Abstract
Obesity
is
a
complex,
chronic,
and
multifactorial
condition
characterized
by
abnormal
fat
accumulation
in
tissues
organs
inducing
negative
effects
on
human
health.
Alzheimer's
disease
progressive
irreversible
neurodegenerative
disease,
associated
with
amyloid
plaques
neurofibrillary
tangles
the
brain.
The
correlation
between
obesity
has
been
discovered,
but
molecules
molecular
mechanisms
linking
these
conditions
are
not
yet
fully
elucidated.
In
this
review,
we
focused
most
important
processes
alterations
of
brain
structure
functions.
